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Viruses join the circular RNA world

Circular RNAs (circRNAs) are a recently discovered class of noncoding RNAs found in many species across the eukaryotic kingdom. These intriguing RNA species are formed through a unique mechanism that is known as back splicing in which the 5 ` and 3 ` termini are covalently joined. Recent research ha...

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Main Authors: Tan, Ke-En, Lim, Yat-Yuen
Format: Article
Published: Wiley 2021
Subjects:
QC Physics
QH301 Biology
Online Access:http://eprints.um.edu.my/26879/
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spelling my.um.eprints.268792022-04-25T05:34:59Z http://eprints.um.edu.my/26879/ Viruses join the circular RNA world Tan, Ke-En Lim, Yat-Yuen QC Physics QH301 Biology Circular RNAs (circRNAs) are a recently discovered class of noncoding RNAs found in many species across the eukaryotic kingdom. These intriguing RNA species are formed through a unique mechanism that is known as back splicing in which the 5 ` and 3 ` termini are covalently joined. Recent research has revealed that viruses also encode a repertoire of circRNAs. Some of these viral circRNAs are abundantly expressed and are reported to play a role in disease pathogenesis. A growing number of studies also indicate that host circRNAs are involved in immune responses against virus infections with either an antiviral or proviral role. In this review, we briefly introduce circRNA, its biogenesis, and mechanism of action. We go on to summarize the latest research on the expression, regulation, and functions of viral and host-encoded circRNAs during the host-virus interaction, with the aim of highlighting the potential of viral and host circRNAs as a suitable target for diagnostic biomarker development and therapeutic treatment of viral-associated diseases. We conclude by discussing the current limitations in knowledge and significance of elucidating the roles of circRNAs in host-virus interactions, as well as future directions for this emerging field. Wiley 2021-08 Article PeerReviewed Tan, Ke-En and Lim, Yat-Yuen (2021) Viruses join the circular RNA world. FEBS Journal, 288 (15). pp. 4488-4502. ISSN 1742-464X, DOI https://doi.org/10.1111/febs.15639 <https://doi.org/10.1111/febs.15639>. 10.1111/febs.15639
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QC Physics
QH301 Biology
spellingShingle QC Physics
QH301 Biology
Tan, Ke-En
Lim, Yat-Yuen
Viruses join the circular RNA world
description Circular RNAs (circRNAs) are a recently discovered class of noncoding RNAs found in many species across the eukaryotic kingdom. These intriguing RNA species are formed through a unique mechanism that is known as back splicing in which the 5 ` and 3 ` termini are covalently joined. Recent research has revealed that viruses also encode a repertoire of circRNAs. Some of these viral circRNAs are abundantly expressed and are reported to play a role in disease pathogenesis. A growing number of studies also indicate that host circRNAs are involved in immune responses against virus infections with either an antiviral or proviral role. In this review, we briefly introduce circRNA, its biogenesis, and mechanism of action. We go on to summarize the latest research on the expression, regulation, and functions of viral and host-encoded circRNAs during the host-virus interaction, with the aim of highlighting the potential of viral and host circRNAs as a suitable target for diagnostic biomarker development and therapeutic treatment of viral-associated diseases. We conclude by discussing the current limitations in knowledge and significance of elucidating the roles of circRNAs in host-virus interactions, as well as future directions for this emerging field.
format Article
author Tan, Ke-En
Lim, Yat-Yuen
author_facet Tan, Ke-En
Lim, Yat-Yuen
author_sort Tan, Ke-En
title Viruses join the circular RNA world
title_short Viruses join the circular RNA world
title_full Viruses join the circular RNA world
title_fullStr Viruses join the circular RNA world
title_full_unstemmed Viruses join the circular RNA world
title_sort viruses join the circular rna world
publisher Wiley
publishDate 2021
url http://eprints.um.edu.my/26879/
_version_ 1735409470520950784
score 13.211869

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