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Mindfulness-based intervention to promote psychological wellbeing in people with epilepsy: A randomized controlled trial

Background: We investigated the efficacy of mindfulness-based intervention (MBI) in promoting psychological wellbeing in people with epilepsy (PWE) using an assessor-blinded randomized controlled design. Methods: A total of 28 PWE were randomly assigned to either intervention (n = 14 cases) or contr...

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Main Authors: Lai, Siew-Tim, Lim, Kheng-Seang, Tang, Venus, Low, Wah-Yun
Format: Article
Published: Elsevier 2021
Subjects:
R Medicine (General)
Online Access:http://eprints.um.edu.my/26583/
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spelling my.um.eprints.265832022-03-23T07:40:22Z http://eprints.um.edu.my/26583/ Mindfulness-based intervention to promote psychological wellbeing in people with epilepsy: A randomized controlled trial Lai, Siew-Tim Lim, Kheng-Seang Tang, Venus Low, Wah-Yun R Medicine (General) Background: We investigated the efficacy of mindfulness-based intervention (MBI) in promoting psychological wellbeing in people with epilepsy (PWE) using an assessor-blinded randomized controlled design. Methods: A total of 28 PWE were randomly assigned to either intervention (n = 14 cases) or control group (n = 14 controls). The intervention group received a six 2.5-hour weekly MBI, while the control group did not receive any intervention. They were assessed at three timepoints (T0: before intervention, T1: immediately after intervention, and T2: 6 weeks after intervention). Repeated measures of analyses of variance (RM-ANOVAs) were used for inter-group comparisons to determine intervention effect from baseline-to T1 and -to T2 for all outcome measures. The individual changes were calculated using the reliable change index (RCI). Key outcomes included depression (BDI-II), anxiety (BAI), epilepsy-related quality of life (QOLIE-31), satisfaction with life (SWLS), and level of mindfulness (MAAS). Results: Participants who participated in the MBI showed significant reduction in BDI-II (p = 0.001), significant increases in MAAS (p = 0.027) and QOLIE-31 (p = 0.001) at T1 when compared with the control group. However, BAI and SWLS were not significant. The trend was similar at 6-week follow-up, all outcome measures of MBI remained significant (p < 0.05) except for BAI and SWLS. Beyond the 6-week intervention, RCI analysis showed a significant improvement in levels of mindfulness (45.45% vs. 21.43%, p = 0.009), depression (45.45% vs. 0.00%, p = 0.016), quality of life (45.45% vs. 14.29%, p = 0.017) with MBI, as compared to the no-intervention phase. Conclusion: Mindfulness-based intervention is effective in reducing psychological distress and improving the quality of life in PWE. (C) 2021 Elsevier Inc. All rights reserved. Elsevier 2021-05 Article PeerReviewed Lai, Siew-Tim and Lim, Kheng-Seang and Tang, Venus and Low, Wah-Yun (2021) Mindfulness-based intervention to promote psychological wellbeing in people with epilepsy: A randomized controlled trial. Epilepsy & Behavior, 118. ISSN 1525-5050, DOI https://doi.org/10.1016/j.yebeh.2021.107916 <https://doi.org/10.1016/j.yebeh.2021.107916>. 10.1016/j.yebeh.2021.107916
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine (General)
spellingShingle R Medicine (General)
Lai, Siew-Tim
Lim, Kheng-Seang
Tang, Venus
Low, Wah-Yun
Mindfulness-based intervention to promote psychological wellbeing in people with epilepsy: A randomized controlled trial
description Background: We investigated the efficacy of mindfulness-based intervention (MBI) in promoting psychological wellbeing in people with epilepsy (PWE) using an assessor-blinded randomized controlled design. Methods: A total of 28 PWE were randomly assigned to either intervention (n = 14 cases) or control group (n = 14 controls). The intervention group received a six 2.5-hour weekly MBI, while the control group did not receive any intervention. They were assessed at three timepoints (T0: before intervention, T1: immediately after intervention, and T2: 6 weeks after intervention). Repeated measures of analyses of variance (RM-ANOVAs) were used for inter-group comparisons to determine intervention effect from baseline-to T1 and -to T2 for all outcome measures. The individual changes were calculated using the reliable change index (RCI). Key outcomes included depression (BDI-II), anxiety (BAI), epilepsy-related quality of life (QOLIE-31), satisfaction with life (SWLS), and level of mindfulness (MAAS). Results: Participants who participated in the MBI showed significant reduction in BDI-II (p = 0.001), significant increases in MAAS (p = 0.027) and QOLIE-31 (p = 0.001) at T1 when compared with the control group. However, BAI and SWLS were not significant. The trend was similar at 6-week follow-up, all outcome measures of MBI remained significant (p < 0.05) except for BAI and SWLS. Beyond the 6-week intervention, RCI analysis showed a significant improvement in levels of mindfulness (45.45% vs. 21.43%, p = 0.009), depression (45.45% vs. 0.00%, p = 0.016), quality of life (45.45% vs. 14.29%, p = 0.017) with MBI, as compared to the no-intervention phase. Conclusion: Mindfulness-based intervention is effective in reducing psychological distress and improving the quality of life in PWE. (C) 2021 Elsevier Inc. All rights reserved.
format Article
author Lai, Siew-Tim
Lim, Kheng-Seang
Tang, Venus
Low, Wah-Yun
author_facet Lai, Siew-Tim
Lim, Kheng-Seang
Tang, Venus
Low, Wah-Yun
author_sort Lai, Siew-Tim
title Mindfulness-based intervention to promote psychological wellbeing in people with epilepsy: A randomized controlled trial
title_short Mindfulness-based intervention to promote psychological wellbeing in people with epilepsy: A randomized controlled trial
title_full Mindfulness-based intervention to promote psychological wellbeing in people with epilepsy: A randomized controlled trial
title_fullStr Mindfulness-based intervention to promote psychological wellbeing in people with epilepsy: A randomized controlled trial
title_full_unstemmed Mindfulness-based intervention to promote psychological wellbeing in people with epilepsy: A randomized controlled trial
title_sort mindfulness-based intervention to promote psychological wellbeing in people with epilepsy: a randomized controlled trial
publisher Elsevier
publishDate 2021
url http://eprints.um.edu.my/26583/
_version_ 1735409431383900160
score 13.211869

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