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Nanotherapeutics for treating coronavirus diseases

Viral diseases have recently become a threat to human health and rapidly become a significant cause of mortality with a continually exacerbated unfavorable socio-economic impact. Coronaviruses, including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome (MERS...

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Main Authors: Gunathilake, Thennakoon M. Sampath U., Ching, Yern Chee, Uyama, Hiroshi, Chuah, Cheng Hock
Format: Article
Published: Elsevier 2021
Subjects:
QD Chemistry
RM Therapeutics. Pharmacology
TP Chemical technology
Online Access:http://eprints.um.edu.my/26570/
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spelling my.um.eprints.265702022-03-18T08:23:16Z http://eprints.um.edu.my/26570/ Nanotherapeutics for treating coronavirus diseases Gunathilake, Thennakoon M. Sampath U. Ching, Yern Chee Uyama, Hiroshi Chuah, Cheng Hock QD Chemistry RM Therapeutics. Pharmacology TP Chemical technology Viral diseases have recently become a threat to human health and rapidly become a significant cause of mortality with a continually exacerbated unfavorable socio-economic impact. Coronaviruses, including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome (MERS-CoV), and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), have threatened human life, with immense accompanying morbidity rates; the COVID-19 (caused by SARS-CoV-2) epidemic has become a severe threat to global public health. In addition, the design process of antiviral medications usually takes years before the treatments can be made readily available. Hence, it is necessary to invest scientifically and financially in a technology platform that can then be quickly repurposed on demand to be adequately positioned for this kind of pandemic situation through lessons learned from the previous pandemics. Nanomaterials/nanoformulations provide such platform technologies, and a proper investigation into their basic science and biological interactions would be of great benefit for potential vaccine and therapeutic development. In this respect, intelligent and advanced nano-based technologies provide specific physico-chemical properties, which can help fix the key issues related to the treatments of viral infections. This review aims to provide an overview of the latest research on the effective use of nanomaterials in the treatment of coronaviruses. Also raised are the problems, perspectives of antiviral nanoformulations, and the possibility of using nanomaterials effectively against current pandemic situations. Elsevier 2021-08 Article PeerReviewed Gunathilake, Thennakoon M. Sampath U. and Ching, Yern Chee and Uyama, Hiroshi and Chuah, Cheng Hock (2021) Nanotherapeutics for treating coronavirus diseases. Journal of Drug Delivery Science and Technology, 64. ISSN 1773-2247, DOI https://doi.org/10.1016/j.jddst.2021.102634 <https://doi.org/10.1016/j.jddst.2021.102634>. 10.1016/j.jddst.2021.102634
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QD Chemistry
RM Therapeutics. Pharmacology
TP Chemical technology
spellingShingle QD Chemistry
RM Therapeutics. Pharmacology
TP Chemical technology
Gunathilake, Thennakoon M. Sampath U.
Ching, Yern Chee
Uyama, Hiroshi
Chuah, Cheng Hock
Nanotherapeutics for treating coronavirus diseases
description Viral diseases have recently become a threat to human health and rapidly become a significant cause of mortality with a continually exacerbated unfavorable socio-economic impact. Coronaviruses, including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome (MERS-CoV), and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), have threatened human life, with immense accompanying morbidity rates; the COVID-19 (caused by SARS-CoV-2) epidemic has become a severe threat to global public health. In addition, the design process of antiviral medications usually takes years before the treatments can be made readily available. Hence, it is necessary to invest scientifically and financially in a technology platform that can then be quickly repurposed on demand to be adequately positioned for this kind of pandemic situation through lessons learned from the previous pandemics. Nanomaterials/nanoformulations provide such platform technologies, and a proper investigation into their basic science and biological interactions would be of great benefit for potential vaccine and therapeutic development. In this respect, intelligent and advanced nano-based technologies provide specific physico-chemical properties, which can help fix the key issues related to the treatments of viral infections. This review aims to provide an overview of the latest research on the effective use of nanomaterials in the treatment of coronaviruses. Also raised are the problems, perspectives of antiviral nanoformulations, and the possibility of using nanomaterials effectively against current pandemic situations.
format Article
author Gunathilake, Thennakoon M. Sampath U.
Ching, Yern Chee
Uyama, Hiroshi
Chuah, Cheng Hock
author_facet Gunathilake, Thennakoon M. Sampath U.
Ching, Yern Chee
Uyama, Hiroshi
Chuah, Cheng Hock
author_sort Gunathilake, Thennakoon M. Sampath U.
title Nanotherapeutics for treating coronavirus diseases
title_short Nanotherapeutics for treating coronavirus diseases
title_full Nanotherapeutics for treating coronavirus diseases
title_fullStr Nanotherapeutics for treating coronavirus diseases
title_full_unstemmed Nanotherapeutics for treating coronavirus diseases
title_sort nanotherapeutics for treating coronavirus diseases
publisher Elsevier
publishDate 2021
url http://eprints.um.edu.my/26570/
_version_ 1735409429613903872
score 13.211869

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