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Molecularly imprinted polymers-based DNA biosensors

In multiple biological processes, molecular recognition performs an integral role in detecting bio analytes. Molecular imprinted polymers (MIPs) are tailored sensing materials that can biomimic the biologic ligands and can detect specific target molecules selectively and sensitively. The formulation...

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Main Authors: Nawaz, Noman, Abu Bakar, Nor Kartini, Mahmud, Habibun Nabi Muhammad Ekramul, Jamaludin, Nazzatush Shimar
Format: Article
Published: Academic Press Inc Elsevier Science 2021
Subjects:
QD Chemistry
QH301 Biology
Online Access:http://eprints.um.edu.my/26564/
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spelling my.um.eprints.265642022-03-18T04:06:38Z http://eprints.um.edu.my/26564/ Molecularly imprinted polymers-based DNA biosensors Nawaz, Noman Abu Bakar, Nor Kartini Mahmud, Habibun Nabi Muhammad Ekramul Jamaludin, Nazzatush Shimar QD Chemistry QH301 Biology In multiple biological processes, molecular recognition performs an integral role in detecting bio analytes. Molecular imprinted polymers (MIPs) are tailored sensing materials that can biomimic the biologic ligands and can detect specific target molecules selectively and sensitively. The formulation of molecularly imprinted polymers is followed by the formulation of a control termed as non-imprinted polymer (NIP), which, in the absence of a template, is commonly formulated to evaluate whether distinctive imprints have been produced for the template. Given the difficulties confronting bioanalytical researchers, it is inevitable that this strategy would come out as a central route of multidisciplinary studies to create extremely promising stable artificial receptors as a replacement or accelerate biological matrices. The ease of synthesis, low cost, capability to `tailor' recognition element for analyte molecules, and stability under harsh environments make MIPs promising candidates as a recognition tool for biosensing. Compared to biological systems, molecular imprinting techniques have several advantages, including high recognition ability, long-term durability, low cost, and robustness, allowing molecularly imprinted polymers to be employed in drug delivery, biosensor technology, and nanotechnology. Molecular imprinted polymer-based sensors still have certain shortcomings in determining biomacromolecules (nucleic acid, protein, lipids, and carbohydrates), considering the vast volume of the latest literature on biomicromolecules. These potential materials are still required to address a few weaknesses until gaining their position in recognition of biomacromolecules. This review aims to highlight the current progress in molecularly imprinted polymers (MIPs)-based sensors for the determination of deoxyribonucleic acid (DNA) or nucleobases. Academic Press Inc Elsevier Science 2021-10-01 Article PeerReviewed Nawaz, Noman and Abu Bakar, Nor Kartini and Mahmud, Habibun Nabi Muhammad Ekramul and Jamaludin, Nazzatush Shimar (2021) Molecularly imprinted polymers-based DNA biosensors. Analytical Biochemistry, 630. ISSN 0003-2697, DOI https://doi.org/10.1016/j.ab.2021.114328 <https://doi.org/10.1016/j.ab.2021.114328>. 10.1016/j.ab.2021.114328
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QD Chemistry
QH301 Biology
spellingShingle QD Chemistry
QH301 Biology
Nawaz, Noman
Abu Bakar, Nor Kartini
Mahmud, Habibun Nabi Muhammad Ekramul
Jamaludin, Nazzatush Shimar
Molecularly imprinted polymers-based DNA biosensors
description In multiple biological processes, molecular recognition performs an integral role in detecting bio analytes. Molecular imprinted polymers (MIPs) are tailored sensing materials that can biomimic the biologic ligands and can detect specific target molecules selectively and sensitively. The formulation of molecularly imprinted polymers is followed by the formulation of a control termed as non-imprinted polymer (NIP), which, in the absence of a template, is commonly formulated to evaluate whether distinctive imprints have been produced for the template. Given the difficulties confronting bioanalytical researchers, it is inevitable that this strategy would come out as a central route of multidisciplinary studies to create extremely promising stable artificial receptors as a replacement or accelerate biological matrices. The ease of synthesis, low cost, capability to `tailor' recognition element for analyte molecules, and stability under harsh environments make MIPs promising candidates as a recognition tool for biosensing. Compared to biological systems, molecular imprinting techniques have several advantages, including high recognition ability, long-term durability, low cost, and robustness, allowing molecularly imprinted polymers to be employed in drug delivery, biosensor technology, and nanotechnology. Molecular imprinted polymer-based sensors still have certain shortcomings in determining biomacromolecules (nucleic acid, protein, lipids, and carbohydrates), considering the vast volume of the latest literature on biomicromolecules. These potential materials are still required to address a few weaknesses until gaining their position in recognition of biomacromolecules. This review aims to highlight the current progress in molecularly imprinted polymers (MIPs)-based sensors for the determination of deoxyribonucleic acid (DNA) or nucleobases.
format Article
author Nawaz, Noman
Abu Bakar, Nor Kartini
Mahmud, Habibun Nabi Muhammad Ekramul
Jamaludin, Nazzatush Shimar
author_facet Nawaz, Noman
Abu Bakar, Nor Kartini
Mahmud, Habibun Nabi Muhammad Ekramul
Jamaludin, Nazzatush Shimar
author_sort Nawaz, Noman
title Molecularly imprinted polymers-based DNA biosensors
title_short Molecularly imprinted polymers-based DNA biosensors
title_full Molecularly imprinted polymers-based DNA biosensors
title_fullStr Molecularly imprinted polymers-based DNA biosensors
title_full_unstemmed Molecularly imprinted polymers-based DNA biosensors
title_sort molecularly imprinted polymers-based dna biosensors
publisher Academic Press Inc Elsevier Science
publishDate 2021
url http://eprints.um.edu.my/26564/
_version_ 1735409428983709696
score 13.211869

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