Cover Image

Lipid-based nanoparticles for psoriasis treatment: A review on conventional treatments, recent works, and future prospects

Psoriasis is a lingering inflammatory skin disease that attacks the immune system. The abnormal interactions between T cells, immune cells, and inflammatory cytokines causing the epidermal thickening. International guidelines have recommended topical treatments for mild to moderate psoriasis whilst...

Full description

Saved in:
Bibliographic Details
Main Authors: Nordin, Ummu Umaimah Mohd, Ahmad, Noraini, Salim, Norazlinaliza, Yusof, Nor Saadah Mohd
Format: Article
Published: Royal Society of Chemistry 2021
Subjects:
QD Chemistry
Online Access:http://eprints.um.edu.my/26519/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.um.eprints.26519
record_format eprints
spelling my.um.eprints.265192022-03-10T08:33:05Z http://eprints.um.edu.my/26519/ Lipid-based nanoparticles for psoriasis treatment: A review on conventional treatments, recent works, and future prospects Nordin, Ummu Umaimah Mohd Ahmad, Noraini Salim, Norazlinaliza Yusof, Nor Saadah Mohd QD Chemistry Psoriasis is a lingering inflammatory skin disease that attacks the immune system. The abnormal interactions between T cells, immune cells, and inflammatory cytokines causing the epidermal thickening. International guidelines have recommended topical treatments for mild to moderate psoriasis whilst systemic and phototherapy treatments for moderate to severe psoriasis. However, current therapeutic approaches have a wider extent to treat moderate to severe type of psoriasis especially since the emergence of diverse biologic agents. In the meantime, topical delivery of conventional treatments has prompted many unsatisfactory effects to penetrate through the skin (stratum corneum). By understanding the physiology of stratum corneum barrier functions, scientists have developed different types of lipid-based nanoparticles like solid lipid nanoparticles, nanostructured lipid carriers, nanovesicles, and nanoemulsions. These novel drug delivery systems help the poorly solubilised active pharmaceutical ingredient reaches the targeted site seamlessly because of the bioavailability feature of the nanosized molecules. Lipid-based nanoparticles for psoriasis treatments create a paradigm for topical drug delivery due to their lipids' amphiphilic feature to efficiently encapsulate both lipophilic and hydrophilic drugs. This review highlights different types of lipid-based nanoparticles and their recent works of nano formulated psoriasis treatments. The encapsulation of psoriasis drugs through lipid nanocarriers unfold numerous research opportunities in pharmaceutical applications but also draw challenges for the future development of nano drugs. Royal Society of Chemistry 2021-09-08 Article PeerReviewed Nordin, Ummu Umaimah Mohd and Ahmad, Noraini and Salim, Norazlinaliza and Yusof, Nor Saadah Mohd (2021) Lipid-based nanoparticles for psoriasis treatment: A review on conventional treatments, recent works, and future prospects. RSC Advances, 11 (46). pp. 29080-29101. ISSN 2046-2069, DOI https://doi.org/10.1039/d1ra06087b <https://doi.org/10.1039/d1ra06087b>. 10.1039/d1ra06087b
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QD Chemistry
spellingShingle QD Chemistry
Nordin, Ummu Umaimah Mohd
Ahmad, Noraini
Salim, Norazlinaliza
Yusof, Nor Saadah Mohd
Lipid-based nanoparticles for psoriasis treatment: A review on conventional treatments, recent works, and future prospects
description Psoriasis is a lingering inflammatory skin disease that attacks the immune system. The abnormal interactions between T cells, immune cells, and inflammatory cytokines causing the epidermal thickening. International guidelines have recommended topical treatments for mild to moderate psoriasis whilst systemic and phototherapy treatments for moderate to severe psoriasis. However, current therapeutic approaches have a wider extent to treat moderate to severe type of psoriasis especially since the emergence of diverse biologic agents. In the meantime, topical delivery of conventional treatments has prompted many unsatisfactory effects to penetrate through the skin (stratum corneum). By understanding the physiology of stratum corneum barrier functions, scientists have developed different types of lipid-based nanoparticles like solid lipid nanoparticles, nanostructured lipid carriers, nanovesicles, and nanoemulsions. These novel drug delivery systems help the poorly solubilised active pharmaceutical ingredient reaches the targeted site seamlessly because of the bioavailability feature of the nanosized molecules. Lipid-based nanoparticles for psoriasis treatments create a paradigm for topical drug delivery due to their lipids' amphiphilic feature to efficiently encapsulate both lipophilic and hydrophilic drugs. This review highlights different types of lipid-based nanoparticles and their recent works of nano formulated psoriasis treatments. The encapsulation of psoriasis drugs through lipid nanocarriers unfold numerous research opportunities in pharmaceutical applications but also draw challenges for the future development of nano drugs.
format Article
author Nordin, Ummu Umaimah Mohd
Ahmad, Noraini
Salim, Norazlinaliza
Yusof, Nor Saadah Mohd
author_facet Nordin, Ummu Umaimah Mohd
Ahmad, Noraini
Salim, Norazlinaliza
Yusof, Nor Saadah Mohd
author_sort Nordin, Ummu Umaimah Mohd
title Lipid-based nanoparticles for psoriasis treatment: A review on conventional treatments, recent works, and future prospects
title_short Lipid-based nanoparticles for psoriasis treatment: A review on conventional treatments, recent works, and future prospects
title_full Lipid-based nanoparticles for psoriasis treatment: A review on conventional treatments, recent works, and future prospects
title_fullStr Lipid-based nanoparticles for psoriasis treatment: A review on conventional treatments, recent works, and future prospects
title_full_unstemmed Lipid-based nanoparticles for psoriasis treatment: A review on conventional treatments, recent works, and future prospects
title_sort lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects
publisher Royal Society of Chemistry
publishDate 2021
url http://eprints.um.edu.my/26519/
_version_ 1735409423071838208
score 13.211869

Similar Items