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Lignosus rhinocerus TM02 (R) sclerotia extract inhibits dengue virus replication and Infection

Lignosus rhinocerus (L. rhinocerus) is a rare in Southeast Asia and has been long used by the natives for various medicinal purposes. In the advent of the mushroom's successful cultivation, a novel cultivar, named L.rhinocerus TM02 (R), was produced and has been tested for anti-inflammatory, an...

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Main Authors: Khazali, Ahmad Suhail, Rashid, Nurshamimi Nor, Fung, Shin-Yee, Yusof, Rohana
Format: Article
Published: Elsevier 2021
Subjects:
R Medicine (General)
Online Access:http://eprints.um.edu.my/26508/
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spelling my.um.eprints.265082022-03-09T07:28:05Z http://eprints.um.edu.my/26508/ Lignosus rhinocerus TM02 (R) sclerotia extract inhibits dengue virus replication and Infection Khazali, Ahmad Suhail Rashid, Nurshamimi Nor Fung, Shin-Yee Yusof, Rohana R Medicine (General) Lignosus rhinocerus (L. rhinocerus) is a rare in Southeast Asia and has been long used by the natives for various medicinal purposes. In the advent of the mushroom's successful cultivation, a novel cultivar, named L.rhinocerus TM02 (R), was produced and has been tested for anti-inflammatory, anti-proliferative, antioxidant, and other medicinal properties. However, the antiviral effects of TM02 (R) cultivar have not been demonstrated. In this study, the antiviral properties of cold-water extract (CWE) from the sclerotium of L.rhinocerus TM02 (R) cultivar were investigated, in inhibiting dengue serotype 2 infection in Vero cells. The authors observed a dose-dependent inhibition on dengue virus replication, particularly during the early stage of dengue infection. The extract also exhibited a significant virucidal effect and displayed a mild prophylactic effect. Hence, in the absence of antidengue treatment and limited dengue vaccination, these results indicate that TM02 (R) CWE may serve as an alternative medicine in reducing dengue infection. Further studies are required to identify and verify the bioactive compounds of TM02 (R) CWE that mediate the antiviral activity. Elsevier 2021-12 Article PeerReviewed Khazali, Ahmad Suhail and Rashid, Nurshamimi Nor and Fung, Shin-Yee and Yusof, Rohana (2021) Lignosus rhinocerus TM02 (R) sclerotia extract inhibits dengue virus replication and Infection. Journal of Herbal Medicine, 30. ISSN 2210-8033, DOI https://doi.org/10.1016/j.hermed.2021.100505 <https://doi.org/10.1016/j.hermed.2021.100505>. 10.1016/j.hermed.2021.100505
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine (General)
spellingShingle R Medicine (General)
Khazali, Ahmad Suhail
Rashid, Nurshamimi Nor
Fung, Shin-Yee
Yusof, Rohana
Lignosus rhinocerus TM02 (R) sclerotia extract inhibits dengue virus replication and Infection
description Lignosus rhinocerus (L. rhinocerus) is a rare in Southeast Asia and has been long used by the natives for various medicinal purposes. In the advent of the mushroom's successful cultivation, a novel cultivar, named L.rhinocerus TM02 (R), was produced and has been tested for anti-inflammatory, anti-proliferative, antioxidant, and other medicinal properties. However, the antiviral effects of TM02 (R) cultivar have not been demonstrated. In this study, the antiviral properties of cold-water extract (CWE) from the sclerotium of L.rhinocerus TM02 (R) cultivar were investigated, in inhibiting dengue serotype 2 infection in Vero cells. The authors observed a dose-dependent inhibition on dengue virus replication, particularly during the early stage of dengue infection. The extract also exhibited a significant virucidal effect and displayed a mild prophylactic effect. Hence, in the absence of antidengue treatment and limited dengue vaccination, these results indicate that TM02 (R) CWE may serve as an alternative medicine in reducing dengue infection. Further studies are required to identify and verify the bioactive compounds of TM02 (R) CWE that mediate the antiviral activity.
format Article
author Khazali, Ahmad Suhail
Rashid, Nurshamimi Nor
Fung, Shin-Yee
Yusof, Rohana
author_facet Khazali, Ahmad Suhail
Rashid, Nurshamimi Nor
Fung, Shin-Yee
Yusof, Rohana
author_sort Khazali, Ahmad Suhail
title Lignosus rhinocerus TM02 (R) sclerotia extract inhibits dengue virus replication and Infection
title_short Lignosus rhinocerus TM02 (R) sclerotia extract inhibits dengue virus replication and Infection
title_full Lignosus rhinocerus TM02 (R) sclerotia extract inhibits dengue virus replication and Infection
title_fullStr Lignosus rhinocerus TM02 (R) sclerotia extract inhibits dengue virus replication and Infection
title_full_unstemmed Lignosus rhinocerus TM02 (R) sclerotia extract inhibits dengue virus replication and Infection
title_sort lignosus rhinocerus tm02 (r) sclerotia extract inhibits dengue virus replication and infection
publisher Elsevier
publishDate 2021
url http://eprints.um.edu.my/26508/
_version_ 1735409421614317568
score 13.211869

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