Cover Image

Functional outcome at one year following moderate to severe traumatic brain injury: A prospective study in Malaysia

Background & Objective: Traumatic brain injury (TBI) is a leading cause of disability among young adult population. Those with more severe TBI continue to experience long term disability. This research aimed to describe the functional outcome of moderate to severe TBI patients at one year post-i...

Full description

Saved in:
Bibliographic Details
Main Authors: Mazlan, Mazlina, Rahman, Zafefe Abd, Chan, Soo Chin, Hamzah, Norhamizan
Format: Article
Published: ASEAN Neurological Association 2021
Subjects:
R Medicine (General)
Online Access:http://eprints.um.edu.my/26484/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.um.eprints.26484
record_format eprints
spelling my.um.eprints.264842022-03-08T02:30:10Z http://eprints.um.edu.my/26484/ Functional outcome at one year following moderate to severe traumatic brain injury: A prospective study in Malaysia Mazlan, Mazlina Rahman, Zafefe Abd Chan, Soo Chin Hamzah, Norhamizan R Medicine (General) Background & Objective: Traumatic brain injury (TBI) is a leading cause of disability among young adult population. Those with more severe TBI continue to experience long term disability. This research aimed to describe the functional outcome of moderate to severe TBI patients at one year post-injury in a Malaysian setting. Methods: This was a prospective cohort study conducted at University Malaya Medical Centre (UMMC) involving 100 patients who were admitted with moderate to severe TBI. The functional outcome was assessed at one year post injury using Glasgow Outcome Scale-Extended (GOSE). Factors associated with good outcome were analysed via regression analysis. Results: The mean age of the study participants was 39.4 (+/- 17.6). Majority of participants were male, less than 40 years old and involved in a motor vehicle accident. Good outcome (GOSE score of 7 & 8) at one year was reported in 25% of the patients. Factors significantly affecting functional outcome were age, premorbid marital status, education level, presence of concomitant extremity fractures and early inpatient rehabilitation (p <0.05). After adjusting for the confounding factors, absence of concomitant extremity fractures was found to be a significant predictor for good functional outcome at one year (OR 9.26, 95% CI 1.86 - 46.12, p = 0.007) Conclusion: Good functional outcome at one year following moderate to severe TBI in our population is lower than other studies worldwide. However, factors influencing good outcome at one year is comparable to other developed countries. Early management of concomitant extremity fractures may allow patients to participate in early inpatient rehabilitation for a better outcome. ASEAN Neurological Association 2021-03 Article PeerReviewed Mazlan, Mazlina and Rahman, Zafefe Abd and Chan, Soo Chin and Hamzah, Norhamizan (2021) Functional outcome at one year following moderate to severe traumatic brain injury: A prospective study in Malaysia. Neurology Asia, 26 (1). pp. 135-143. ISSN 1823-6138,
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine (General)
spellingShingle R Medicine (General)
Mazlan, Mazlina
Rahman, Zafefe Abd
Chan, Soo Chin
Hamzah, Norhamizan
Functional outcome at one year following moderate to severe traumatic brain injury: A prospective study in Malaysia
description Background & Objective: Traumatic brain injury (TBI) is a leading cause of disability among young adult population. Those with more severe TBI continue to experience long term disability. This research aimed to describe the functional outcome of moderate to severe TBI patients at one year post-injury in a Malaysian setting. Methods: This was a prospective cohort study conducted at University Malaya Medical Centre (UMMC) involving 100 patients who were admitted with moderate to severe TBI. The functional outcome was assessed at one year post injury using Glasgow Outcome Scale-Extended (GOSE). Factors associated with good outcome were analysed via regression analysis. Results: The mean age of the study participants was 39.4 (+/- 17.6). Majority of participants were male, less than 40 years old and involved in a motor vehicle accident. Good outcome (GOSE score of 7 & 8) at one year was reported in 25% of the patients. Factors significantly affecting functional outcome were age, premorbid marital status, education level, presence of concomitant extremity fractures and early inpatient rehabilitation (p <0.05). After adjusting for the confounding factors, absence of concomitant extremity fractures was found to be a significant predictor for good functional outcome at one year (OR 9.26, 95% CI 1.86 - 46.12, p = 0.007) Conclusion: Good functional outcome at one year following moderate to severe TBI in our population is lower than other studies worldwide. However, factors influencing good outcome at one year is comparable to other developed countries. Early management of concomitant extremity fractures may allow patients to participate in early inpatient rehabilitation for a better outcome.
format Article
author Mazlan, Mazlina
Rahman, Zafefe Abd
Chan, Soo Chin
Hamzah, Norhamizan
author_facet Mazlan, Mazlina
Rahman, Zafefe Abd
Chan, Soo Chin
Hamzah, Norhamizan
author_sort Mazlan, Mazlina
title Functional outcome at one year following moderate to severe traumatic brain injury: A prospective study in Malaysia
title_short Functional outcome at one year following moderate to severe traumatic brain injury: A prospective study in Malaysia
title_full Functional outcome at one year following moderate to severe traumatic brain injury: A prospective study in Malaysia
title_fullStr Functional outcome at one year following moderate to severe traumatic brain injury: A prospective study in Malaysia
title_full_unstemmed Functional outcome at one year following moderate to severe traumatic brain injury: A prospective study in Malaysia
title_sort functional outcome at one year following moderate to severe traumatic brain injury: a prospective study in malaysia
publisher ASEAN Neurological Association
publishDate 2021
url http://eprints.um.edu.my/26484/
_version_ 1735409418783162368
score 13.211869

Similar Items