Staff View: Medication Adherence for Haemophilia Patients: Outcome of Prophylaxis Treatment Intervention

Medication Adherence for Haemophilia Patients: Outcome of Prophylaxis Treatment Intervention

There have been various Haemophilia Treatment Centres (HTCs) set up worldwide with innovative blood factor stewardship programs. Pharmacists have been an extended part of stewardship programs providing daily rounds with haematologists, treatment plan modifications, and dosage adjustment recommendati...

Full description

Saved in:

Bibliographic Details
Main Authors:	Mohd Mokhtar, Fadzlin, Sathar, Jameela, Huri, Hasniza Zaman
Format:	Article
Published:	MDPI 2021
Subjects:	RS Pharmacy and materia medica
Online Access:	http://eprints.um.edu.my/26079/ https://doi.org/10.3390/healthcare9121702
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my.um.eprints.26079
record_format	eprints
spelling	my.um.eprints.260792021-12-29T03:05:43Z http://eprints.um.edu.my/26079/ Medication Adherence for Haemophilia Patients: Outcome of Prophylaxis Treatment Intervention Mohd Mokhtar, Fadzlin Sathar, Jameela Huri, Hasniza Zaman RS Pharmacy and materia medica There have been various Haemophilia Treatment Centres (HTCs) set up worldwide with innovative blood factor stewardship programs. Pharmacists have been an extended part of stewardship programs providing daily rounds with haematologists, treatment plan modifications, and dosage adjustment recommendations. The Haemophilia Treatment Centres in Malaysia contain the Haemophilia Medication Therapy Adherence Clinic (HMTAC), which recruits adolescent and adult populations. There have not been any adherence studies conducted on pharmacist-steered HMTAC since initiation. The current research generates baseline data to produce treatment plans and intervention measures needed for therapy optimisation in the Malaysian population. This study also explores the relationship between medication adherence, bleeding rate, and comorbidity. This cross-sectional study involved retrospective and prospective data collection using the Validated Haemophilia Regimen Treatment Adherence Scale–Prophylaxis (VERITAS-Pro) in Ampang Hospital. The retrospective data collection included reviewing patients’ medical records, bleeding diaries, and VERITAS-Pro questionnaires pre-enrolment to HMTAC. Meanwhile, the prospective data collection was the VERITAS-Pro questionnaire administration post a minimum of three months after enrolment. The inclusion criteria were patients with severe haemophilia A and B with ages ≥18 years with self-administered prophylactic regimens for a minimum period of three months. There were six (5.8%) nonadherent participants, and 97 (94.2%) adhered to the preventive treatment. The subscale dosing and remembering and the total score of the VERITAS-Pro post-HMTAC showed a significant association with ABR. There was a significant mean reduction in the post-HMTAC compared to the pre-HMTAC score for the total score and subscales timing, remembering, skipping, and communicating. There was a significant association between the post-HMTAC adherence status and ABR. It can be concluded that the HMTAC service pioneered by the pharmacists in the National Referral Centre of Haematology is efficient in significantly improving the VERITAS-Pro scoring and then translating it into a high medication adherence rate. This study also highlights a significant correlation between post-HMTAC scores on their adherence with ABR and comorbidities. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. MDPI 2021 Article PeerReviewed Mohd Mokhtar, Fadzlin and Sathar, Jameela and Huri, Hasniza Zaman (2021) Medication Adherence for Haemophilia Patients: Outcome of Prophylaxis Treatment Intervention. Healthcare, 9 (12). p. 1702. ISSN 2227-9032 https://doi.org/10.3390/healthcare9121702 doi:10.3390/healthcare9121702
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Mohd Mokhtar, Fadzlin Sathar, Jameela Huri, Hasniza Zaman Medication Adherence for Haemophilia Patients: Outcome of Prophylaxis Treatment Intervention
description	There have been various Haemophilia Treatment Centres (HTCs) set up worldwide with innovative blood factor stewardship programs. Pharmacists have been an extended part of stewardship programs providing daily rounds with haematologists, treatment plan modifications, and dosage adjustment recommendations. The Haemophilia Treatment Centres in Malaysia contain the Haemophilia Medication Therapy Adherence Clinic (HMTAC), which recruits adolescent and adult populations. There have not been any adherence studies conducted on pharmacist-steered HMTAC since initiation. The current research generates baseline data to produce treatment plans and intervention measures needed for therapy optimisation in the Malaysian population. This study also explores the relationship between medication adherence, bleeding rate, and comorbidity. This cross-sectional study involved retrospective and prospective data collection using the Validated Haemophilia Regimen Treatment Adherence Scale–Prophylaxis (VERITAS-Pro) in Ampang Hospital. The retrospective data collection included reviewing patients’ medical records, bleeding diaries, and VERITAS-Pro questionnaires pre-enrolment to HMTAC. Meanwhile, the prospective data collection was the VERITAS-Pro questionnaire administration post a minimum of three months after enrolment. The inclusion criteria were patients with severe haemophilia A and B with ages ≥18 years with self-administered prophylactic regimens for a minimum period of three months. There were six (5.8%) nonadherent participants, and 97 (94.2%) adhered to the preventive treatment. The subscale dosing and remembering and the total score of the VERITAS-Pro post-HMTAC showed a significant association with ABR. There was a significant mean reduction in the post-HMTAC compared to the pre-HMTAC score for the total score and subscales timing, remembering, skipping, and communicating. There was a significant association between the post-HMTAC adherence status and ABR. It can be concluded that the HMTAC service pioneered by the pharmacists in the National Referral Centre of Haematology is efficient in significantly improving the VERITAS-Pro scoring and then translating it into a high medication adherence rate. This study also highlights a significant correlation between post-HMTAC scores on their adherence with ABR and comorbidities. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
format	Article
author	Mohd Mokhtar, Fadzlin Sathar, Jameela Huri, Hasniza Zaman
author_facet	Mohd Mokhtar, Fadzlin Sathar, Jameela Huri, Hasniza Zaman
author_sort	Mohd Mokhtar, Fadzlin
title	Medication Adherence for Haemophilia Patients: Outcome of Prophylaxis Treatment Intervention
title_short	Medication Adherence for Haemophilia Patients: Outcome of Prophylaxis Treatment Intervention
title_full	Medication Adherence for Haemophilia Patients: Outcome of Prophylaxis Treatment Intervention
title_fullStr	Medication Adherence for Haemophilia Patients: Outcome of Prophylaxis Treatment Intervention
title_full_unstemmed	Medication Adherence for Haemophilia Patients: Outcome of Prophylaxis Treatment Intervention
title_sort	medication adherence for haemophilia patients: outcome of prophylaxis treatment intervention
publisher	MDPI
publishDate	2021
url	http://eprints.um.edu.my/26079/ https://doi.org/10.3390/healthcare9121702
_version_	1720980439658659840
score	13.211869

Medication Adherence for Haemophilia Patients: Outcome of Prophylaxis Treatment Intervention

Similar Items