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The incidence of pregnancy-induced hypertension among patients with carbohydrate intolerance

Objective: To determine the association between pregnancy-induced hypertension (PIH) and carbohydrate intolerance in pregnancy. Methods: Data on singleton pregnancies were retrieved from the obstetric database of University Hospital, Kuala Lumpur. Gestational impaired glucose tolerance (GIGT) and ge...

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Main Authors: Roach, Vijay J., Hin, Lin Yee, Tam, Wing Hung, Ng, Kwee Boon, Rogers, Michael S.
Format: Article
Published: Taylor & Francis 2000
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R Medicine
Online Access:http://eprints.um.edu.my/26019/
https://doi.org/10.1081/PRG-100100134
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spelling my.um.eprints.260192021-09-02T03:45:03Z http://eprints.um.edu.my/26019/ The incidence of pregnancy-induced hypertension among patients with carbohydrate intolerance Roach, Vijay J. Hin, Lin Yee Tam, Wing Hung Ng, Kwee Boon Rogers, Michael S. R Medicine Objective: To determine the association between pregnancy-induced hypertension (PIH) and carbohydrate intolerance in pregnancy. Methods: Data on singleton pregnancies were retrieved from the obstetric database of University Hospital, Kuala Lumpur. Gestational impaired glucose tolerance (GIGT) and gestational diabetes mellitus (GDM) were defined according to the World Health Organization criteria. Established diabetes mellitus (EDM) was defined as diabetes mellitus diagnosed prior to pregnancy. PIH was diagnosed according to the criteria of the International Society for the Study of Hypertension in Pregnancy. Maternal characteristics were compared between groups using analysis of variance (ANOVA) and incidence counts using the chi- squared test. Logistic regression analysis using the presence of PIH as the response variable was used to study the association among GDM, GIGT, EDM, and PIH, controlling for maternal factors. Main Outcome Measures: To determine the incidence of PIH among patients with glucose intolerance and the independent risk factors for the development of PIH. Results: There were 24,290 singleton pregnancies retrieved from the database. Both the prevalence of carbohydrate intolerance and the incidence of PIH differed among the three principal ethnic groups (p < 0.0001). There was a significant association between PIH and both a higher maternal age (OR = 1.04, p < 0.0001) and a higher maternal body mass index (BMI) at delivery (OR = 1.14 per unit increment, p < 0.0001). After adjusting for maternal age, BMI, parity, and ethnic origin, using logistic regression, there was a significant residual risk of PIH among individuals with GIGT, GDM, or EDM. Conclusions: Patients with carbohydrate intolerance of varying severity are at increased risk of developing PIH. Our findings lend credence to the theory that carbohydrate intolerance and PIH share a common etiology. Taylor & Francis 2000 Article PeerReviewed Roach, Vijay J. and Hin, Lin Yee and Tam, Wing Hung and Ng, Kwee Boon and Rogers, Michael S. (2000) The incidence of pregnancy-induced hypertension among patients with carbohydrate intolerance. Hypertension in Pregnancy, 19 (2). pp. 183-189. ISSN 1064-1955 https://doi.org/10.1081/PRG-100100134 doi:10.1081/PRG-100100134
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Roach, Vijay J.
Hin, Lin Yee
Tam, Wing Hung
Ng, Kwee Boon
Rogers, Michael S.
The incidence of pregnancy-induced hypertension among patients with carbohydrate intolerance
description Objective: To determine the association between pregnancy-induced hypertension (PIH) and carbohydrate intolerance in pregnancy. Methods: Data on singleton pregnancies were retrieved from the obstetric database of University Hospital, Kuala Lumpur. Gestational impaired glucose tolerance (GIGT) and gestational diabetes mellitus (GDM) were defined according to the World Health Organization criteria. Established diabetes mellitus (EDM) was defined as diabetes mellitus diagnosed prior to pregnancy. PIH was diagnosed according to the criteria of the International Society for the Study of Hypertension in Pregnancy. Maternal characteristics were compared between groups using analysis of variance (ANOVA) and incidence counts using the chi- squared test. Logistic regression analysis using the presence of PIH as the response variable was used to study the association among GDM, GIGT, EDM, and PIH, controlling for maternal factors. Main Outcome Measures: To determine the incidence of PIH among patients with glucose intolerance and the independent risk factors for the development of PIH. Results: There were 24,290 singleton pregnancies retrieved from the database. Both the prevalence of carbohydrate intolerance and the incidence of PIH differed among the three principal ethnic groups (p < 0.0001). There was a significant association between PIH and both a higher maternal age (OR = 1.04, p < 0.0001) and a higher maternal body mass index (BMI) at delivery (OR = 1.14 per unit increment, p < 0.0001). After adjusting for maternal age, BMI, parity, and ethnic origin, using logistic regression, there was a significant residual risk of PIH among individuals with GIGT, GDM, or EDM. Conclusions: Patients with carbohydrate intolerance of varying severity are at increased risk of developing PIH. Our findings lend credence to the theory that carbohydrate intolerance and PIH share a common etiology.
format Article
author Roach, Vijay J.
Hin, Lin Yee
Tam, Wing Hung
Ng, Kwee Boon
Rogers, Michael S.
author_facet Roach, Vijay J.
Hin, Lin Yee
Tam, Wing Hung
Ng, Kwee Boon
Rogers, Michael S.
author_sort Roach, Vijay J.
title The incidence of pregnancy-induced hypertension among patients with carbohydrate intolerance
title_short The incidence of pregnancy-induced hypertension among patients with carbohydrate intolerance
title_full The incidence of pregnancy-induced hypertension among patients with carbohydrate intolerance
title_fullStr The incidence of pregnancy-induced hypertension among patients with carbohydrate intolerance
title_full_unstemmed The incidence of pregnancy-induced hypertension among patients with carbohydrate intolerance
title_sort incidence of pregnancy-induced hypertension among patients with carbohydrate intolerance
publisher Taylor & Francis
publishDate 2000
url http://eprints.um.edu.my/26019/
https://doi.org/10.1081/PRG-100100134
_version_ 1710675851248402432
score 13.211869

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