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Distinctive Clinico-Pathological Characteristics of Colorectal Cancer in Sabahan Indigenous Populations

Malaysia is an ethnically diverse nation, comprising Malay, Chinese, Indian and indigenous groups. However, epidemiological studies on colorectal cancer have mainly focused on the three main ethnic groups. There is evidence that the clinico-pathological characteristics of some cancers may differ in...

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Main Authors: Valan, Anuradha, Najid, Fatimah, Chandran, Pradeep, Abd Rahim, Azuwani, Chuah, Jitt, Roslani, April Camilla
Format: Article
Published: West Asia Organization for Cancer Prevention 2021
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/25967/
https://doi.org/10.31557/APJCP.2021.22.3.749
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spelling my.um.eprints.259672021-05-07T03:22:30Z http://eprints.um.edu.my/25967/ Distinctive Clinico-Pathological Characteristics of Colorectal Cancer in Sabahan Indigenous Populations Valan, Anuradha Najid, Fatimah Chandran, Pradeep Abd Rahim, Azuwani Chuah, Jitt Roslani, April Camilla R Medicine Malaysia is an ethnically diverse nation, comprising Malay, Chinese, Indian and indigenous groups. However, epidemiological studies on colorectal cancer have mainly focused on the three main ethnic groups. There is evidence that the clinico-pathological characteristics of some cancers may differ in indigenous populations, namely that they occur earlier and behave more aggressively. We aimed to determine if there were similar differences in colorectal cancer, focusing on the indigenous populations of Sabah. Methods: Histopathological reports of all patients diagnosed with colorectal carcinoma from January 2012 to December 2016 from public hospitals in Sabah were retrieved from the central computerized database of the Pathology Department of Queen Elizabeth Hospital in Kota Kinabalu, Sabah. Supplementary data was obtained from patients’ case files from each hospital. Clinico-pathological data were analysed using the IBM SPSS Statistical Software Version 23 for Windows for descriptive statistics (mean, median, ASR, AR, relative risk) and inferential statistics (Chi square test). Results: A total of 696 patients met the inclusion criteria. The median age for colorectal cancer in Sabah was 62 years (95% CI 60.3 to 62.3), with an age specific incidence rate of 21.4 per 100 000 population. The age specific incidence rate in the indigenous populations was 26.6 per 100 000, much lower than the Chinese, at 65.0 per 100 000. The risk of colorectal cancer occurring before the age of 50 was three times higher in the indigenous population compared to the Chinese. The tumours were mainly left-sided (56.5%), adenocarcinoma in histology (98.4%) and moderately differentiated (88.7%). Approximately 79.2% of patients received curative treatment. Conclusion: Indigenous populations in Sabah develop colorectal cancer at an earlier age, and present at more advanced stages. This has implications for screening and therapeutic strategic planning. © 2021. All Rights Reserved. West Asia Organization for Cancer Prevention 2021 Article PeerReviewed Valan, Anuradha and Najid, Fatimah and Chandran, Pradeep and Abd Rahim, Azuwani and Chuah, Jitt and Roslani, April Camilla (2021) Distinctive Clinico-Pathological Characteristics of Colorectal Cancer in Sabahan Indigenous Populations. Asian Pacific Journal of Cancer Prevention, 22 (3). pp. 749-755. ISSN 1513-7368 https://doi.org/10.31557/APJCP.2021.22.3.749 doi:10.31557/APJCP.2021.22.3.749
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Valan, Anuradha
Najid, Fatimah
Chandran, Pradeep
Abd Rahim, Azuwani
Chuah, Jitt
Roslani, April Camilla
Distinctive Clinico-Pathological Characteristics of Colorectal Cancer in Sabahan Indigenous Populations
description Malaysia is an ethnically diverse nation, comprising Malay, Chinese, Indian and indigenous groups. However, epidemiological studies on colorectal cancer have mainly focused on the three main ethnic groups. There is evidence that the clinico-pathological characteristics of some cancers may differ in indigenous populations, namely that they occur earlier and behave more aggressively. We aimed to determine if there were similar differences in colorectal cancer, focusing on the indigenous populations of Sabah. Methods: Histopathological reports of all patients diagnosed with colorectal carcinoma from January 2012 to December 2016 from public hospitals in Sabah were retrieved from the central computerized database of the Pathology Department of Queen Elizabeth Hospital in Kota Kinabalu, Sabah. Supplementary data was obtained from patients’ case files from each hospital. Clinico-pathological data were analysed using the IBM SPSS Statistical Software Version 23 for Windows for descriptive statistics (mean, median, ASR, AR, relative risk) and inferential statistics (Chi square test). Results: A total of 696 patients met the inclusion criteria. The median age for colorectal cancer in Sabah was 62 years (95% CI 60.3 to 62.3), with an age specific incidence rate of 21.4 per 100 000 population. The age specific incidence rate in the indigenous populations was 26.6 per 100 000, much lower than the Chinese, at 65.0 per 100 000. The risk of colorectal cancer occurring before the age of 50 was three times higher in the indigenous population compared to the Chinese. The tumours were mainly left-sided (56.5%), adenocarcinoma in histology (98.4%) and moderately differentiated (88.7%). Approximately 79.2% of patients received curative treatment. Conclusion: Indigenous populations in Sabah develop colorectal cancer at an earlier age, and present at more advanced stages. This has implications for screening and therapeutic strategic planning. © 2021. All Rights Reserved.
format Article
author Valan, Anuradha
Najid, Fatimah
Chandran, Pradeep
Abd Rahim, Azuwani
Chuah, Jitt
Roslani, April Camilla
author_facet Valan, Anuradha
Najid, Fatimah
Chandran, Pradeep
Abd Rahim, Azuwani
Chuah, Jitt
Roslani, April Camilla
author_sort Valan, Anuradha
title Distinctive Clinico-Pathological Characteristics of Colorectal Cancer in Sabahan Indigenous Populations
title_short Distinctive Clinico-Pathological Characteristics of Colorectal Cancer in Sabahan Indigenous Populations
title_full Distinctive Clinico-Pathological Characteristics of Colorectal Cancer in Sabahan Indigenous Populations
title_fullStr Distinctive Clinico-Pathological Characteristics of Colorectal Cancer in Sabahan Indigenous Populations
title_full_unstemmed Distinctive Clinico-Pathological Characteristics of Colorectal Cancer in Sabahan Indigenous Populations
title_sort distinctive clinico-pathological characteristics of colorectal cancer in sabahan indigenous populations
publisher West Asia Organization for Cancer Prevention
publishDate 2021
url http://eprints.um.edu.my/25967/
https://doi.org/10.31557/APJCP.2021.22.3.749
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score 13.211869

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