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Lipid Synthesis in Rats during Cold Acclimatization

The effect of cold environment on the biosynthesis of lipids in warm-blooded animals was studied in terms of incorporation of acetate-14C into cholesterol and fatty acids of serum, liver and carcass of rats exposed to cold at 0-2°C, for up to 28 days. The results were compared with those of normothe...

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Main Author: Bhattathiry, Madhava
Format: Article
Published: Oxford University Press 1971
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/25798/
https://doi.org/10.1093/oxfordjournals.jbchem.a129480
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spelling my.um.eprints.257982021-03-23T01:22:52Z http://eprints.um.edu.my/25798/ Lipid Synthesis in Rats during Cold Acclimatization Bhattathiry, Madhava R Medicine The effect of cold environment on the biosynthesis of lipids in warm-blooded animals was studied in terms of incorporation of acetate-14C into cholesterol and fatty acids of serum, liver and carcass of rats exposed to cold at 0-2°C, for up to 28 days. The results were compared with those of normothermic rats.In in vivo studies, the serum cholesterol concentration of cold-exposed rats was found to be higher, but the liver cholesterol concentration showed little changes. An initial decrease followed by a slight increase in total lipids of both serum and liver of cold-exposed rats was observed. The specific activity of total lipids from serum and liver and of serum cholesterol was very low during the first few days of cold-exposure but gradually reached normal values. At the end of 28 days the specific activity of serum cholesterol was higher in the case of cold-exposed rats, whereas the specific activity of liver cholesterol was higher for the first few days of exposure and slowly reached normal values in 28 days.In in vitro studies using liver slices from cold-exposed and normothermic rats, the specific activity of both total cholesterol and fatty acids from livers of cold-exposed rats was low during the first few days, but gradually increased and showed12-Jan times and 3 times activity respectively in cholesterol and fatty acids at the end of 28 days of exposure to cold. © 1970, by the Japanese Biochemical Society. Oxford University Press 1971 Article PeerReviewed Bhattathiry, Madhava (1971) Lipid Synthesis in Rats during Cold Acclimatization. The Journal of Biochemistry, 69 (2). pp. 415-420. ISSN 0021-924X https://doi.org/10.1093/oxfordjournals.jbchem.a129480 doi:10.1093/oxfordjournals.jbchem.a129480
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Bhattathiry, Madhava
Lipid Synthesis in Rats during Cold Acclimatization
description The effect of cold environment on the biosynthesis of lipids in warm-blooded animals was studied in terms of incorporation of acetate-14C into cholesterol and fatty acids of serum, liver and carcass of rats exposed to cold at 0-2°C, for up to 28 days. The results were compared with those of normothermic rats.In in vivo studies, the serum cholesterol concentration of cold-exposed rats was found to be higher, but the liver cholesterol concentration showed little changes. An initial decrease followed by a slight increase in total lipids of both serum and liver of cold-exposed rats was observed. The specific activity of total lipids from serum and liver and of serum cholesterol was very low during the first few days of cold-exposure but gradually reached normal values. At the end of 28 days the specific activity of serum cholesterol was higher in the case of cold-exposed rats, whereas the specific activity of liver cholesterol was higher for the first few days of exposure and slowly reached normal values in 28 days.In in vitro studies using liver slices from cold-exposed and normothermic rats, the specific activity of both total cholesterol and fatty acids from livers of cold-exposed rats was low during the first few days, but gradually increased and showed12-Jan times and 3 times activity respectively in cholesterol and fatty acids at the end of 28 days of exposure to cold. © 1970, by the Japanese Biochemical Society.
format Article
author Bhattathiry, Madhava
author_facet Bhattathiry, Madhava
author_sort Bhattathiry, Madhava
title Lipid Synthesis in Rats during Cold Acclimatization
title_short Lipid Synthesis in Rats during Cold Acclimatization
title_full Lipid Synthesis in Rats during Cold Acclimatization
title_fullStr Lipid Synthesis in Rats during Cold Acclimatization
title_full_unstemmed Lipid Synthesis in Rats during Cold Acclimatization
title_sort lipid synthesis in rats during cold acclimatization
publisher Oxford University Press
publishDate 1971
url http://eprints.um.edu.my/25798/
https://doi.org/10.1093/oxfordjournals.jbchem.a129480
_version_ 1695531096745181184
score 13.211869

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