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Clinical and genetic markers of erythropoietin deficiency anemia in chronic kidney disease (predialysis) patients

Aim: To determine the clinical and genetic markers associated with erythropoietin deficiency anemia in predialysis individuals. Materials & methods: Patients were categorized into cases and control group. Demographic characteristics and clinical parameters were obtained from medical record revie...

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Main Authors:	Yugavathy, Nava, Huri, Hasniza Zaman, Lim, Soo Kun, Abdul Gafor, Abdul Halim, Wong, Muh Geot, Bavanandan, Sunita, Wong, Hing Seng
Format:	Article
Published:	Future Medicine 2020
Subjects:	R Medicine RS Pharmacy and materia medica
Online Access:	http://eprints.um.edu.my/25740/ https://doi.org/10.2217/bmm-2020-0205
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spelling	my.um.eprints.257402021-02-09T07:48:01Z http://eprints.um.edu.my/25740/ Clinical and genetic markers of erythropoietin deficiency anemia in chronic kidney disease (predialysis) patients Yugavathy, Nava Huri, Hasniza Zaman Lim, Soo Kun Abdul Gafor, Abdul Halim Wong, Muh Geot Bavanandan, Sunita Wong, Hing Seng R Medicine RS Pharmacy and materia medica Aim: To determine the clinical and genetic markers associated with erythropoietin deficiency anemia in predialysis individuals. Materials & methods: Patients were categorized into cases and control group. Demographic characteristics and clinical parameters were obtained from medical record review and serum EPO and ferritin were obtained with ELISA. HIF-1α (rs2057482), IL-1β (rs1143627) and EPO (rs1617640) gene polymorphism were genotyped. Results: Female gender, glomerular filtration rate, treatment with hematinics, anticoagulant and diuretic were strong predictors of EPO-deficient anemia in predialysis chronic kidney disease patients. Genetic polymorphism in the HIF-1α recessive model was associated with non-EPO-deficiency, followed by EPO recessive allele associated with low-serum erythropoietin and IL-1β recessive model with low hemoglobin level. Conclusion: EPO-deficiency anemia can be diagnosed more conveniently in the presence of biomarkers. © 2020 Future Medicine 2020 Article PeerReviewed Yugavathy, Nava and Huri, Hasniza Zaman and Lim, Soo Kun and Abdul Gafor, Abdul Halim and Wong, Muh Geot and Bavanandan, Sunita and Wong, Hing Seng (2020) Clinical and genetic markers of erythropoietin deficiency anemia in chronic kidney disease (predialysis) patients. Biomarkers in Medicine, 14 (12). pp. 1099-1108. ISSN 1752-0363 https://doi.org/10.2217/bmm-2020-0205 doi:10.2217/bmm-2020-0205
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine RS Pharmacy and materia medica
spellingShingle	R Medicine RS Pharmacy and materia medica Yugavathy, Nava Huri, Hasniza Zaman Lim, Soo Kun Abdul Gafor, Abdul Halim Wong, Muh Geot Bavanandan, Sunita Wong, Hing Seng Clinical and genetic markers of erythropoietin deficiency anemia in chronic kidney disease (predialysis) patients
description	Aim: To determine the clinical and genetic markers associated with erythropoietin deficiency anemia in predialysis individuals. Materials & methods: Patients were categorized into cases and control group. Demographic characteristics and clinical parameters were obtained from medical record review and serum EPO and ferritin were obtained with ELISA. HIF-1α (rs2057482), IL-1β (rs1143627) and EPO (rs1617640) gene polymorphism were genotyped. Results: Female gender, glomerular filtration rate, treatment with hematinics, anticoagulant and diuretic were strong predictors of EPO-deficient anemia in predialysis chronic kidney disease patients. Genetic polymorphism in the HIF-1α recessive model was associated with non-EPO-deficiency, followed by EPO recessive allele associated with low-serum erythropoietin and IL-1β recessive model with low hemoglobin level. Conclusion: EPO-deficiency anemia can be diagnosed more conveniently in the presence of biomarkers. © 2020
format	Article
author	Yugavathy, Nava Huri, Hasniza Zaman Lim, Soo Kun Abdul Gafor, Abdul Halim Wong, Muh Geot Bavanandan, Sunita Wong, Hing Seng
author_facet	Yugavathy, Nava Huri, Hasniza Zaman Lim, Soo Kun Abdul Gafor, Abdul Halim Wong, Muh Geot Bavanandan, Sunita Wong, Hing Seng
author_sort	Yugavathy, Nava
title	Clinical and genetic markers of erythropoietin deficiency anemia in chronic kidney disease (predialysis) patients
title_short	Clinical and genetic markers of erythropoietin deficiency anemia in chronic kidney disease (predialysis) patients
title_full	Clinical and genetic markers of erythropoietin deficiency anemia in chronic kidney disease (predialysis) patients
title_fullStr	Clinical and genetic markers of erythropoietin deficiency anemia in chronic kidney disease (predialysis) patients
title_full_unstemmed	Clinical and genetic markers of erythropoietin deficiency anemia in chronic kidney disease (predialysis) patients
title_sort	clinical and genetic markers of erythropoietin deficiency anemia in chronic kidney disease (predialysis) patients
publisher	Future Medicine
publishDate	2020
url	http://eprints.um.edu.my/25740/ https://doi.org/10.2217/bmm-2020-0205
_version_	1691733433864159232
score	13.211869

Clinical and genetic markers of erythropoietin deficiency anemia in chronic kidney disease (predialysis) patients

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