Cytotoxic Activity of Pereskia bleo (Cactaceae) Against Selected Human Cell Lines
Pereskia bleo (Cactaceae) was investigated for its cytotoxic effect against selected human cell lines, namely the Human Nasopharyngeal Fpidermoid Carcinoma Cell Line (KB), Human Cervical Carcinoma Cell Line (CasKi), Human Colon Carcinoma Cell Line (HCT 116), Hormone-Dependent Breast Carcinoma Cell L...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Published: |
Asian Network for Scientific Information
2007
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/25664/ https://doi.org/10.3923/ijcr.2008.20.27 |
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| Summary: | Pereskia bleo (Cactaceae) was investigated for its cytotoxic effect against selected human cell lines, namely the Human Nasopharyngeal Fpidermoid Carcinoma Cell Line (KB), Human Cervical Carcinoma Cell Line (CasKi), Human Colon Carcinoma Cell Line (HCT 116), Hormone-Dependent Breast Carcinoma Cell Line (MCF7) and non-cancer Human Fibroblast Cell Line (MRC-5) by using an in vitro neutral red cytotoxicity assay. All the crude methanolic and its fractionated extracts (hexane, ethyl acetate and water) exert no damage to the MRC-5 normal cells. The crude methanol extract and the ethyl acetate fraction of Pereskia bleo possessed notably high cytotoxic effect against KB cells with IC50 values of 6.5 and 4.5 μg mL-1, respectively. Four compounds isolated from the ethyl acetate fraction of Pereskia bleo were identified as phytol, β-sitosterol, 2,4-di-tert-butylphenol and vitamin E. All four compounds have not been reported for this plant. © 2008 Academic Journals Inc. |
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