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Statistical analysis of one-pot lipase-catalyzed esterification of ϵ-caprolactone with methyl- -glucopyranoside and its extension

One-pot synthesis of oligomeric sugar ester was carried out by lipase-catalyzed esterification of ε-caprolactone (ECL) with methyl-d-glucopyranoside (MGP) followed by the chain extension of ECL monomer/oligomer. Two-level half fractional factorial design was employed to analyse the effects of select...

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Main Authors: Saat, Muhammad Naziz, Annuar, Mohamad Suffian Mohamad
Format: Article
Published: Elsevier 2020
Subjects:
Q Science (General)
QH Natural history
Online Access:http://eprints.um.edu.my/25207/
https://doi.org/10.1016/j.bcab.2019.101464
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spelling my.um.eprints.252072020-07-28T03:28:04Z http://eprints.um.edu.my/25207/ Statistical analysis of one-pot lipase-catalyzed esterification of ϵ-caprolactone with methyl- -glucopyranoside and its extension Saat, Muhammad Naziz Annuar, Mohamad Suffian Mohamad Q Science (General) QH Natural history One-pot synthesis of oligomeric sugar ester was carried out by lipase-catalyzed esterification of ε-caprolactone (ECL) with methyl-d-glucopyranoside (MGP) followed by the chain extension of ECL monomer/oligomer. Two-level half fractional factorial design was employed to analyse the effects of selected operating variables namely lipase loading (1.2–2.8% w/v), initial ECL (3.8–11.5% w/v), initial MGP (0.04–0.14% w/v), temperature (40–60 °C) and agitation (90–180 rpm) as a function of maximum dry weight (% w/v) of MGP-6-O-oligo-ECL. It was found that individual variables viz. lipase loading, initial ECL and temperature affect the maximum product formation. The interaction effects between variables indicated the presence of relationship among them. Spectroscopic authentication showed the presence of covalent bond between the hydroxyl group of MGP with carboxylic acid end group of ECL monomer/oligomer. Thermal analysis indicated three degradation stages of functionalized oligomer. The molecular weight analysis of the functionalized oligomer was observed at 1655 g mol−1 with narrow PDI value of 1.36. Conversion of initial ECL was 90% compared to 14% of initial MGP. © 2019 Elsevier Ltd Elsevier 2020 Article PeerReviewed Saat, Muhammad Naziz and Annuar, Mohamad Suffian Mohamad (2020) Statistical analysis of one-pot lipase-catalyzed esterification of ϵ-caprolactone with methyl- -glucopyranoside and its extension. Biocatalysis and Agricultural Biotechnology, 23. p. 101464. ISSN 1878-8181 https://doi.org/10.1016/j.bcab.2019.101464 doi:10.1016/j.bcab.2019.101464
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic Q Science (General)
QH Natural history
spellingShingle Q Science (General)
QH Natural history
Saat, Muhammad Naziz
Annuar, Mohamad Suffian Mohamad
Statistical analysis of one-pot lipase-catalyzed esterification of ϵ-caprolactone with methyl- -glucopyranoside and its extension
description One-pot synthesis of oligomeric sugar ester was carried out by lipase-catalyzed esterification of ε-caprolactone (ECL) with methyl-d-glucopyranoside (MGP) followed by the chain extension of ECL monomer/oligomer. Two-level half fractional factorial design was employed to analyse the effects of selected operating variables namely lipase loading (1.2–2.8% w/v), initial ECL (3.8–11.5% w/v), initial MGP (0.04–0.14% w/v), temperature (40–60 °C) and agitation (90–180 rpm) as a function of maximum dry weight (% w/v) of MGP-6-O-oligo-ECL. It was found that individual variables viz. lipase loading, initial ECL and temperature affect the maximum product formation. The interaction effects between variables indicated the presence of relationship among them. Spectroscopic authentication showed the presence of covalent bond between the hydroxyl group of MGP with carboxylic acid end group of ECL monomer/oligomer. Thermal analysis indicated three degradation stages of functionalized oligomer. The molecular weight analysis of the functionalized oligomer was observed at 1655 g mol−1 with narrow PDI value of 1.36. Conversion of initial ECL was 90% compared to 14% of initial MGP. © 2019 Elsevier Ltd
format Article
author Saat, Muhammad Naziz
Annuar, Mohamad Suffian Mohamad
author_facet Saat, Muhammad Naziz
Annuar, Mohamad Suffian Mohamad
author_sort Saat, Muhammad Naziz
title Statistical analysis of one-pot lipase-catalyzed esterification of ϵ-caprolactone with methyl- -glucopyranoside and its extension
title_short Statistical analysis of one-pot lipase-catalyzed esterification of ϵ-caprolactone with methyl- -glucopyranoside and its extension
title_full Statistical analysis of one-pot lipase-catalyzed esterification of ϵ-caprolactone with methyl- -glucopyranoside and its extension
title_fullStr Statistical analysis of one-pot lipase-catalyzed esterification of ϵ-caprolactone with methyl- -glucopyranoside and its extension
title_full_unstemmed Statistical analysis of one-pot lipase-catalyzed esterification of ϵ-caprolactone with methyl- -glucopyranoside and its extension
title_sort statistical analysis of one-pot lipase-catalyzed esterification of ϵ-caprolactone with methyl- -glucopyranoside and its extension
publisher Elsevier
publishDate 2020
url http://eprints.um.edu.my/25207/
https://doi.org/10.1016/j.bcab.2019.101464
_version_ 1680857009465851904
score 13.211869

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