Staff View: Exploring the therapeutic potentials of phyto-mediated silver nanoparticles formed via Calotropis procera (Ait.) R. Br. root extract

Exploring the therapeutic potentials of phyto-mediated silver nanoparticles formed via Calotropis procera (Ait.) R. Br. root extract

The objective of this work is to develop cost-effective, reliable, and large-scale production of metallic nanoparticles (NPs) by adopting green chemistry principles for industrial applications. In that view, we have studied the phytochemical reducibility of silver nitrate by making use of Calotropis...

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Main Authors:	Sagadevan, Suresh, Vennila, Selvaraj, Muthukrishnan, Lakshmipathy, Gurunathan, K., Oh, Won Chun, Paiman, Suriati, Mohammad, Faruq, Al-Lohedan, Hamad A., Jasni, Ainil Hawa, Fatimah, Is, Sivaranjan, Kuppan, Obulapuram, Prasanna Kumar
Format:	Article
Published:	Taylor & Francis 2020
Subjects:	Q Science (General) QC Physics QD Chemistry
Online Access:	http://eprints.um.edu.my/25194/ https://doi.org/10.1080/17458080.2020.1769842
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spelling	my.um.eprints.251942020-07-28T02:08:41Z http://eprints.um.edu.my/25194/ Exploring the therapeutic potentials of phyto-mediated silver nanoparticles formed via Calotropis procera (Ait.) R. Br. root extract Sagadevan, Suresh Vennila, Selvaraj Muthukrishnan, Lakshmipathy Gurunathan, K. Oh, Won Chun Paiman, Suriati Mohammad, Faruq Al-Lohedan, Hamad A. Jasni, Ainil Hawa Fatimah, Is Sivaranjan, Kuppan Obulapuram, Prasanna Kumar Q Science (General) QC Physics QD Chemistry The objective of this work is to develop cost-effective, reliable, and large-scale production of metallic nanoparticles (NPs) by adopting green chemistry principles for industrial applications. In that view, we have studied the phytochemical reducibility of silver nitrate by making use of Calotropis Procera (Ait.) R. Br root extract, and based on its medicinal properties, an attempt was made to evaluate the therapeutic potentials of silver (Ag) NPs containing this plant extract towards the clinical strains of bacteria. The optimization studies on reducing the potentials were done considering the concentration, pH, temperature, and reaction period of both the extract and the metal precursor. The nanoarchitecture elements were interpreted using visual, spectroscopic, and microscopic analyses cohorting the antibacterial potentials towards the clinically significant strains. The antimicrobial activity exercised by these Ag NPs towards 10 different strains of medically important bacteria at a given concentration was proved to be significant. The antimicrobial potential was further validated quantitatively, and the MIC/MBC concentration values were determined. Finally, the cytotoxicity of Ag NPs when tested against the HEPK cell line indicated that the metal-phytochemical moiety exhibited the maximum therapeutic efficacy and thereby paving the way for the development of disruptive technologies in the field of nanomedicine. © 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Taylor & Francis 2020 Article PeerReviewed Sagadevan, Suresh and Vennila, Selvaraj and Muthukrishnan, Lakshmipathy and Gurunathan, K. and Oh, Won Chun and Paiman, Suriati and Mohammad, Faruq and Al-Lohedan, Hamad A. and Jasni, Ainil Hawa and Fatimah, Is and Sivaranjan, Kuppan and Obulapuram, Prasanna Kumar (2020) Exploring the therapeutic potentials of phyto-mediated silver nanoparticles formed via Calotropis procera (Ait.) R. Br. root extract. Journal of Experimental Nanoscience, 15 (1). pp. 217-232. ISSN 1745-8080 https://doi.org/10.1080/17458080.2020.1769842 doi:10.1080/17458080.2020.1769842
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	Q Science (General) QC Physics QD Chemistry
spellingShingle	Q Science (General) QC Physics QD Chemistry Sagadevan, Suresh Vennila, Selvaraj Muthukrishnan, Lakshmipathy Gurunathan, K. Oh, Won Chun Paiman, Suriati Mohammad, Faruq Al-Lohedan, Hamad A. Jasni, Ainil Hawa Fatimah, Is Sivaranjan, Kuppan Obulapuram, Prasanna Kumar Exploring the therapeutic potentials of phyto-mediated silver nanoparticles formed via Calotropis procera (Ait.) R. Br. root extract
description	The objective of this work is to develop cost-effective, reliable, and large-scale production of metallic nanoparticles (NPs) by adopting green chemistry principles for industrial applications. In that view, we have studied the phytochemical reducibility of silver nitrate by making use of Calotropis Procera (Ait.) R. Br root extract, and based on its medicinal properties, an attempt was made to evaluate the therapeutic potentials of silver (Ag) NPs containing this plant extract towards the clinical strains of bacteria. The optimization studies on reducing the potentials were done considering the concentration, pH, temperature, and reaction period of both the extract and the metal precursor. The nanoarchitecture elements were interpreted using visual, spectroscopic, and microscopic analyses cohorting the antibacterial potentials towards the clinically significant strains. The antimicrobial activity exercised by these Ag NPs towards 10 different strains of medically important bacteria at a given concentration was proved to be significant. The antimicrobial potential was further validated quantitatively, and the MIC/MBC concentration values were determined. Finally, the cytotoxicity of Ag NPs when tested against the HEPK cell line indicated that the metal-phytochemical moiety exhibited the maximum therapeutic efficacy and thereby paving the way for the development of disruptive technologies in the field of nanomedicine. © 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
format	Article
author	Sagadevan, Suresh Vennila, Selvaraj Muthukrishnan, Lakshmipathy Gurunathan, K. Oh, Won Chun Paiman, Suriati Mohammad, Faruq Al-Lohedan, Hamad A. Jasni, Ainil Hawa Fatimah, Is Sivaranjan, Kuppan Obulapuram, Prasanna Kumar
author_facet	Sagadevan, Suresh Vennila, Selvaraj Muthukrishnan, Lakshmipathy Gurunathan, K. Oh, Won Chun Paiman, Suriati Mohammad, Faruq Al-Lohedan, Hamad A. Jasni, Ainil Hawa Fatimah, Is Sivaranjan, Kuppan Obulapuram, Prasanna Kumar
author_sort	Sagadevan, Suresh
title	Exploring the therapeutic potentials of phyto-mediated silver nanoparticles formed via Calotropis procera (Ait.) R. Br. root extract
title_short	Exploring the therapeutic potentials of phyto-mediated silver nanoparticles formed via Calotropis procera (Ait.) R. Br. root extract
title_full	Exploring the therapeutic potentials of phyto-mediated silver nanoparticles formed via Calotropis procera (Ait.) R. Br. root extract
title_fullStr	Exploring the therapeutic potentials of phyto-mediated silver nanoparticles formed via Calotropis procera (Ait.) R. Br. root extract
title_full_unstemmed	Exploring the therapeutic potentials of phyto-mediated silver nanoparticles formed via Calotropis procera (Ait.) R. Br. root extract
title_sort	exploring the therapeutic potentials of phyto-mediated silver nanoparticles formed via calotropis procera (ait.) r. br. root extract
publisher	Taylor & Francis
publishDate	2020
url	http://eprints.um.edu.my/25194/ https://doi.org/10.1080/17458080.2020.1769842
_version_	1680857007716827136
score	13.211869

Exploring the therapeutic potentials of phyto-mediated silver nanoparticles formed via Calotropis procera (Ait.) R. Br. root extract

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