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Comparison of oxidative damage in Malaysian end-stage renal disease patients with or without non-insulin-dependent diabetes mellitus

Background: Comparisons of oxidative indices and total antioxidant status between end-stage renal disease (ESRD) patients with or without diabetes is scant, especially in the Asian population. Method: The assays were carried out according to known established protocols. Result: The present stu...

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Main Authors: Kuppusamy, U.R., Indran, M., Ahmad, T.S., Wong, S.W., Tan, S.Y., Mahmood, A.A.
Format: Article
Language:English
Published: Elsevier 2005
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/2488/1/Comparison_oxidative_damage.pdf
http://eprints.um.edu.my/2488/
http://www.sciencedirect.com/science/article/pii/S0009898104004668
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spelling my.um.eprints.24882014-10-20T05:18:39Z http://eprints.um.edu.my/2488/ Comparison of oxidative damage in Malaysian end-stage renal disease patients with or without non-insulin-dependent diabetes mellitus Kuppusamy, U.R. Indran, M. Ahmad, T.S. Wong, S.W. Tan, S.Y. Mahmood, A.A. R Medicine Background: Comparisons of oxidative indices and total antioxidant status between end-stage renal disease (ESRD) patients with or without diabetes is scant, especially in the Asian population. Method: The assays were carried out according to known established protocols. Result: The present study showed that ESRD patients with or without non-insulin-dependent diabetes mellitus (NIDDM) did not have any significant differences in antioxidant enzyme activities, advanced glycated end products (AGE), advanced oxidized protein products (AOPP) and ferric reducing ability of plasma (FRAP), indicating that hyperglycemia does not exacerbate oxidative damage in ESRD. The regulation of catalase and glutathione peroxidase is also altered in ESRD. Elevated FRAP was observed in both ESRD groups (with and without NIDDM). The dialysis process did not alter the antioxidant enzyme activities but decreased AGEs and FRAP and increased AOPP levels. Conclusion: Oxidative stress is present in ESRD but this is not significantly exacerbated by hyperglycemia. The contribution of components in the pathology of renal failure towards oxidative stress exceeds that of hyperglycemia. D 2004 Elsevier B.V. All rights reserved. Elsevier 2005-01 Article PeerReviewed application/pdf en http://eprints.um.edu.my/2488/1/Comparison_oxidative_damage.pdf Kuppusamy, U.R. and Indran, M. and Ahmad, T.S. and Wong, S.W. and Tan, S.Y. and Mahmood, A.A. (2005) Comparison of oxidative damage in Malaysian end-stage renal disease patients with or without non-insulin-dependent diabetes mellitus. Clinica Chimica Acta, 351 (1-2). pp. 197-201. ISSN 0009-8981 http://www.sciencedirect.com/science/article/pii/S0009898104004668
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic R Medicine
spellingShingle R Medicine
Kuppusamy, U.R.
Indran, M.
Ahmad, T.S.
Wong, S.W.
Tan, S.Y.
Mahmood, A.A.
Comparison of oxidative damage in Malaysian end-stage renal disease patients with or without non-insulin-dependent diabetes mellitus
description Background: Comparisons of oxidative indices and total antioxidant status between end-stage renal disease (ESRD) patients with or without diabetes is scant, especially in the Asian population. Method: The assays were carried out according to known established protocols. Result: The present study showed that ESRD patients with or without non-insulin-dependent diabetes mellitus (NIDDM) did not have any significant differences in antioxidant enzyme activities, advanced glycated end products (AGE), advanced oxidized protein products (AOPP) and ferric reducing ability of plasma (FRAP), indicating that hyperglycemia does not exacerbate oxidative damage in ESRD. The regulation of catalase and glutathione peroxidase is also altered in ESRD. Elevated FRAP was observed in both ESRD groups (with and without NIDDM). The dialysis process did not alter the antioxidant enzyme activities but decreased AGEs and FRAP and increased AOPP levels. Conclusion: Oxidative stress is present in ESRD but this is not significantly exacerbated by hyperglycemia. The contribution of components in the pathology of renal failure towards oxidative stress exceeds that of hyperglycemia. D 2004 Elsevier B.V. All rights reserved.
format Article
author Kuppusamy, U.R.
Indran, M.
Ahmad, T.S.
Wong, S.W.
Tan, S.Y.
Mahmood, A.A.
author_facet Kuppusamy, U.R.
Indran, M.
Ahmad, T.S.
Wong, S.W.
Tan, S.Y.
Mahmood, A.A.
author_sort Kuppusamy, U.R.
title Comparison of oxidative damage in Malaysian end-stage renal disease patients with or without non-insulin-dependent diabetes mellitus
title_short Comparison of oxidative damage in Malaysian end-stage renal disease patients with or without non-insulin-dependent diabetes mellitus
title_full Comparison of oxidative damage in Malaysian end-stage renal disease patients with or without non-insulin-dependent diabetes mellitus
title_fullStr Comparison of oxidative damage in Malaysian end-stage renal disease patients with or without non-insulin-dependent diabetes mellitus
title_full_unstemmed Comparison of oxidative damage in Malaysian end-stage renal disease patients with or without non-insulin-dependent diabetes mellitus
title_sort comparison of oxidative damage in malaysian end-stage renal disease patients with or without non-insulin-dependent diabetes mellitus
publisher Elsevier
publishDate 2005
url http://eprints.um.edu.my/2488/1/Comparison_oxidative_damage.pdf
http://eprints.um.edu.my/2488/
http://www.sciencedirect.com/science/article/pii/S0009898104004668
_version_ 1643686936258281472
score 13.211869

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