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Dicentrine is preferentially antagonistic to rat aortic than splenic alpha 1-adrenoceptor stimulation

Dicentrine is a known a,-adrenoceptor antagonist,but its a,-adrenoceptor subtype selectivity has not yet been determined. We therefore, investigated the putative a, adrenoceptor subtype selectivity of this agent. METHODS; Graded isometric contractile responses of rat aotric rings and spleen to p...

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Main Authors: Mustafa, Mohd Rais, Achike, F.I.
Format: Article
Language:English
Published: 2000
Subjects:
R Medicine (General)
Online Access:http://eprints.um.edu.my/2458/1/Dicentrine_is_preferentially_antagonistic_to_rat_aortic_than_splenic_alpha_1-adrenoceptor_stimulation.pdf
http://eprints.um.edu.my/2458/
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spelling my.um.eprints.24582019-12-18T06:08:42Z http://eprints.um.edu.my/2458/ Dicentrine is preferentially antagonistic to rat aortic than splenic alpha 1-adrenoceptor stimulation Mustafa, Mohd Rais Achike, F.I. R Medicine (General) Dicentrine is a known a,-adrenoceptor antagonist,but its a,-adrenoceptor subtype selectivity has not yet been determined. We therefore, investigated the putative a, adrenoceptor subtype selectivity of this agent. METHODS; Graded isometric contractile responses of rat aotric rings and spleen to phenylephrine were observed in the absence or presence of various concentrations of dicentrite. The pA2 values for dicentrine were determined. RESULTS; Aortic tissues were more sensitive to phenylephrine-induced contraction than the spleen tissues.Dicentrine was approximately 100 times more potent as an antagonist to the aortic contraction, than it was to the splenic contractions. CONCLUSION: Dicentrine is an a,-adrenoceptor antagonist which is more selective towards the putative a,D-adrenoceptor subtype of the rat aorta than the ale-adrenoceptor of the spleen 2000 Article PeerReviewed application/pdf en http://eprints.um.edu.my/2458/1/Dicentrine_is_preferentially_antagonistic_to_rat_aortic_than_splenic_alpha_1-adrenoceptor_stimulation.pdf Mustafa, Mohd Rais and Achike, F.I. (2000) Dicentrine is preferentially antagonistic to rat aortic than splenic alpha 1-adrenoceptor stimulation. Acta Pharmacologica Sinica, 21 (12). pp. 1165-1168. ISSN 1671-4083
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Mustafa, Mohd Rais
Achike, F.I.
Dicentrine is preferentially antagonistic to rat aortic than splenic alpha 1-adrenoceptor stimulation
description Dicentrine is a known a,-adrenoceptor antagonist,but its a,-adrenoceptor subtype selectivity has not yet been determined. We therefore, investigated the putative a, adrenoceptor subtype selectivity of this agent. METHODS; Graded isometric contractile responses of rat aotric rings and spleen to phenylephrine were observed in the absence or presence of various concentrations of dicentrite. The pA2 values for dicentrine were determined. RESULTS; Aortic tissues were more sensitive to phenylephrine-induced contraction than the spleen tissues.Dicentrine was approximately 100 times more potent as an antagonist to the aortic contraction, than it was to the splenic contractions. CONCLUSION: Dicentrine is an a,-adrenoceptor antagonist which is more selective towards the putative a,D-adrenoceptor subtype of the rat aorta than the ale-adrenoceptor of the spleen
format Article
author Mustafa, Mohd Rais
Achike, F.I.
author_facet Mustafa, Mohd Rais
Achike, F.I.
author_sort Mustafa, Mohd Rais
title Dicentrine is preferentially antagonistic to rat aortic than splenic alpha 1-adrenoceptor stimulation
title_short Dicentrine is preferentially antagonistic to rat aortic than splenic alpha 1-adrenoceptor stimulation
title_full Dicentrine is preferentially antagonistic to rat aortic than splenic alpha 1-adrenoceptor stimulation
title_fullStr Dicentrine is preferentially antagonistic to rat aortic than splenic alpha 1-adrenoceptor stimulation
title_full_unstemmed Dicentrine is preferentially antagonistic to rat aortic than splenic alpha 1-adrenoceptor stimulation
title_sort dicentrine is preferentially antagonistic to rat aortic than splenic alpha 1-adrenoceptor stimulation
publishDate 2000
url http://eprints.um.edu.my/2458/1/Dicentrine_is_preferentially_antagonistic_to_rat_aortic_than_splenic_alpha_1-adrenoceptor_stimulation.pdf
http://eprints.um.edu.my/2458/
_version_ 1654960586297966592
score 13.211869

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