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Effect of des-aspartate-angiotensin I on the actions of angiotensin II in the isolated renal and mesenteric vasculature of hypertensive and STZ-induced diabetic rats

The present study investigated the action of des-aspartate-angiotensin I (DAA-I) on the pressor action of angiotensin II in the renal and mesenteric vasculature of WKY, SHR and streptozotocin (STZ)-induced diabetic rats. Angiotensin II-induced a dose-dependent pressor response in the renal vasculatu...

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Main Authors: Murugan, Dharmani Devi, Mustafa, Mohd Rais, Achike, F.I., Sim, M.K.
Format: Article
Language:English
Published: Elsevier 2005
Subjects:
R Medicine
RM Therapeutics. Pharmacology
Online Access:http://eprints.um.edu.my/2450/1/Effect_of_des-aspartate-angiotensin_I_on_the_actions_of_angiotensin_II_in_the_isolated_renal_and_mesenteric_vasculature_of_hypertensive_and_STZ-induced_diabetic_rats.pdf
http://eprints.um.edu.my/2450/
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spelling my.um.eprints.24502019-12-18T06:18:01Z http://eprints.um.edu.my/2450/ Effect of des-aspartate-angiotensin I on the actions of angiotensin II in the isolated renal and mesenteric vasculature of hypertensive and STZ-induced diabetic rats Murugan, Dharmani Devi Mustafa, Mohd Rais Achike, F.I. Sim, M.K. R Medicine RM Therapeutics. Pharmacology The present study investigated the action of des-aspartate-angiotensin I (DAA-I) on the pressor action of angiotensin II in the renal and mesenteric vasculature of WKY, SHR and streptozotocin (STZ)-induced diabetic rats. Angiotensin II-induced a dose-dependent pressor response in the renal vasculature. Compared to the WKY, the pressor response was enhanced in the SHR and reduced in the STZ-induced diabetic rat. DAA-I attenuated the angiotensin II pressor action in renal vasculature of WKY and SHR. The attenuation was observed for DAA-I concentration as low as 10 18 M and was more prominent in SHR. However, the ability of DAA-I to reduce angiotensin II response was lost in the STZ-induced diabetic kidney. Instead, enhancement of angiotensin II pressor response was seen at the lower doses of the octapeptide. The effect of DAA-I was not inhibited by PD123319, an AT2 receptor antagonist, and indomethacin, a cyclo-oxygenase inhibitor in both WKY and SHR, indicating that its action was not mediated by angiotensin AT2 receptor and prostaglandins. The pressor responses to angiotensin II in mesenteric vascular bed were also dose-dependent but smaller in magnitude compared to the renal vasculature. The responses were significantly smaller in SHR but no significant difference was observed between STZ induced diabetic and WKY rat. Similarly, PD123319 and indomethacin had no effect on the action of DAA-I. The findings reiterate a regulatory role for DAA-I in vascular bed of the kidney and mesentery. By being active at circulating level, DAA-I subserves a physiological role. This function appears to be present in animals with diseased state of hypertension and diabetes. It is likely that DAA-I functions are modified to accommodate the ongoing vascular remodeling Elsevier 2005-03-05 Article PeerReviewed application/pdf en http://eprints.um.edu.my/2450/1/Effect_of_des-aspartate-angiotensin_I_on_the_actions_of_angiotensin_II_in_the_isolated_renal_and_mesenteric_vasculature_of_hypertensive_and_STZ-induced_diabetic_rats.pdf Murugan, Dharmani Devi and Mustafa, Mohd Rais and Achike, F.I. and Sim, M.K. (2005) Effect of des-aspartate-angiotensin I on the actions of angiotensin II in the isolated renal and mesenteric vasculature of hypertensive and STZ-induced diabetic rats. Regulatory Peptides, 129 (1-3). pp. 213-219. ISSN 0167-0115 doi:10.1016/j.regpep.2005.02.007
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic R Medicine
RM Therapeutics. Pharmacology
spellingShingle R Medicine
RM Therapeutics. Pharmacology
Murugan, Dharmani Devi
Mustafa, Mohd Rais
Achike, F.I.
Sim, M.K.
Effect of des-aspartate-angiotensin I on the actions of angiotensin II in the isolated renal and mesenteric vasculature of hypertensive and STZ-induced diabetic rats
description The present study investigated the action of des-aspartate-angiotensin I (DAA-I) on the pressor action of angiotensin II in the renal and mesenteric vasculature of WKY, SHR and streptozotocin (STZ)-induced diabetic rats. Angiotensin II-induced a dose-dependent pressor response in the renal vasculature. Compared to the WKY, the pressor response was enhanced in the SHR and reduced in the STZ-induced diabetic rat. DAA-I attenuated the angiotensin II pressor action in renal vasculature of WKY and SHR. The attenuation was observed for DAA-I concentration as low as 10 18 M and was more prominent in SHR. However, the ability of DAA-I to reduce angiotensin II response was lost in the STZ-induced diabetic kidney. Instead, enhancement of angiotensin II pressor response was seen at the lower doses of the octapeptide. The effect of DAA-I was not inhibited by PD123319, an AT2 receptor antagonist, and indomethacin, a cyclo-oxygenase inhibitor in both WKY and SHR, indicating that its action was not mediated by angiotensin AT2 receptor and prostaglandins. The pressor responses to angiotensin II in mesenteric vascular bed were also dose-dependent but smaller in magnitude compared to the renal vasculature. The responses were significantly smaller in SHR but no significant difference was observed between STZ induced diabetic and WKY rat. Similarly, PD123319 and indomethacin had no effect on the action of DAA-I. The findings reiterate a regulatory role for DAA-I in vascular bed of the kidney and mesentery. By being active at circulating level, DAA-I subserves a physiological role. This function appears to be present in animals with diseased state of hypertension and diabetes. It is likely that DAA-I functions are modified to accommodate the ongoing vascular remodeling
format Article
author Murugan, Dharmani Devi
Mustafa, Mohd Rais
Achike, F.I.
Sim, M.K.
author_facet Murugan, Dharmani Devi
Mustafa, Mohd Rais
Achike, F.I.
Sim, M.K.
author_sort Murugan, Dharmani Devi
title Effect of des-aspartate-angiotensin I on the actions of angiotensin II in the isolated renal and mesenteric vasculature of hypertensive and STZ-induced diabetic rats
title_short Effect of des-aspartate-angiotensin I on the actions of angiotensin II in the isolated renal and mesenteric vasculature of hypertensive and STZ-induced diabetic rats
title_full Effect of des-aspartate-angiotensin I on the actions of angiotensin II in the isolated renal and mesenteric vasculature of hypertensive and STZ-induced diabetic rats
title_fullStr Effect of des-aspartate-angiotensin I on the actions of angiotensin II in the isolated renal and mesenteric vasculature of hypertensive and STZ-induced diabetic rats
title_full_unstemmed Effect of des-aspartate-angiotensin I on the actions of angiotensin II in the isolated renal and mesenteric vasculature of hypertensive and STZ-induced diabetic rats
title_sort effect of des-aspartate-angiotensin i on the actions of angiotensin ii in the isolated renal and mesenteric vasculature of hypertensive and stz-induced diabetic rats
publisher Elsevier
publishDate 2005
url http://eprints.um.edu.my/2450/1/Effect_of_des-aspartate-angiotensin_I_on_the_actions_of_angiotensin_II_in_the_isolated_renal_and_mesenteric_vasculature_of_hypertensive_and_STZ-induced_diabetic_rats.pdf
http://eprints.um.edu.my/2450/
_version_ 1654960585310208000
score 13.211869

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