Investigation of Boldine as a Potential Telomerase Inhibitor by Downregulation of hTERT/hTERC in HCT 116 Human Colon Carcinoma Cells

Telomerase, a ribonucleoprotein (RNP) complex, is a type of RNA-dependent DNA polymerase that synthesises telomeric DNA repeats (TTAGGG) at the 3' end of chromosomes. Most of the cancer cells express high level of telomerase which results in cellular immortality. The high telomerase activity in...

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Main Authors: Ahmad, Nadhirah, Ching, Joo Jie, Majid, Nazia Abdul
格式: Article
出版: Penerbit Universiti Kebangsaan Malaysia 2019
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在线阅读:http://eprints.um.edu.my/24358/
https://doi.org/10.17576/jsm-2019-4809-04
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