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Neuroprotective potential of Spirulina platensis on lesioned spinal cord corticospinal tract under experimental conditions in rat models

Spinal cord injury (SCI) results from penetrating or compressive traumatic injury to the spine in humans or by the surgical compression of the spinal cord in experimental animals. In this study, the neuroprotective potential of Spirulina platensis was investigated on ultrastructural and functional r...

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Main Authors: Abdullahi, Dauda, Annuar, Azlina Ahmad, Sanusi, Junedah
Format: Article
Published: Taylor & Francis 2019
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/24274/
https://doi.org/10.1080/01913123.2019.1695693
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spelling my.um.eprints.242742020-05-05T05:17:11Z http://eprints.um.edu.my/24274/ Neuroprotective potential of Spirulina platensis on lesioned spinal cord corticospinal tract under experimental conditions in rat models Abdullahi, Dauda Annuar, Azlina Ahmad Sanusi, Junedah R Medicine Spinal cord injury (SCI) results from penetrating or compressive traumatic injury to the spine in humans or by the surgical compression of the spinal cord in experimental animals. In this study, the neuroprotective potential of Spirulina platensis was investigated on ultrastructural and functional recovery of the spinal cord following surgical-induced injury. Twenty-four Sprague-Dawley rats were divided into three groups; sham group, control (trauma) group, and experimental (S. platensis) group (180 mg/kg) of eight rats each. For each group, the rats were then subdivided into two groups to allow measurement at two different timepoints (day 14 and 28) for the microscopic analysis. Rats in the control and experimental S. platensis groups were subjected to partial crush injury at the level of T12 with Inox number 2 modified forceps by compressing on the spinal cord for 30 s. Pairwise comparisons of ultrastructural grading mean scores difference between the control and experimental S. platensis groups reveals that there were significant differences on the axonal ultrastructure, myelin sheath and BBB Score on Day 28; these correlate with the functional locomotor recovery at this timepoint. The results suggest that supplementation with S. platensis induces functional recovery and effective preservation of the spinal cord ultrastructure after SCI. These findings will open new potential avenue for further research into the mechanism of S. platensis-mediated spinal cord repair. © 2019, © 2019 Taylor & Francis Group, LLC. Taylor & Francis 2019 Article PeerReviewed Abdullahi, Dauda and Annuar, Azlina Ahmad and Sanusi, Junedah (2019) Neuroprotective potential of Spirulina platensis on lesioned spinal cord corticospinal tract under experimental conditions in rat models. Ultrastructural Pathology, 43 (6). pp. 273-289. ISSN 0191-3123 https://doi.org/10.1080/01913123.2019.1695693 doi:10.1080/01913123.2019.1695693
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Abdullahi, Dauda
Annuar, Azlina Ahmad
Sanusi, Junedah
Neuroprotective potential of Spirulina platensis on lesioned spinal cord corticospinal tract under experimental conditions in rat models
description Spinal cord injury (SCI) results from penetrating or compressive traumatic injury to the spine in humans or by the surgical compression of the spinal cord in experimental animals. In this study, the neuroprotective potential of Spirulina platensis was investigated on ultrastructural and functional recovery of the spinal cord following surgical-induced injury. Twenty-four Sprague-Dawley rats were divided into three groups; sham group, control (trauma) group, and experimental (S. platensis) group (180 mg/kg) of eight rats each. For each group, the rats were then subdivided into two groups to allow measurement at two different timepoints (day 14 and 28) for the microscopic analysis. Rats in the control and experimental S. platensis groups were subjected to partial crush injury at the level of T12 with Inox number 2 modified forceps by compressing on the spinal cord for 30 s. Pairwise comparisons of ultrastructural grading mean scores difference between the control and experimental S. platensis groups reveals that there were significant differences on the axonal ultrastructure, myelin sheath and BBB Score on Day 28; these correlate with the functional locomotor recovery at this timepoint. The results suggest that supplementation with S. platensis induces functional recovery and effective preservation of the spinal cord ultrastructure after SCI. These findings will open new potential avenue for further research into the mechanism of S. platensis-mediated spinal cord repair. © 2019, © 2019 Taylor & Francis Group, LLC.
format Article
author Abdullahi, Dauda
Annuar, Azlina Ahmad
Sanusi, Junedah
author_facet Abdullahi, Dauda
Annuar, Azlina Ahmad
Sanusi, Junedah
author_sort Abdullahi, Dauda
title Neuroprotective potential of Spirulina platensis on lesioned spinal cord corticospinal tract under experimental conditions in rat models
title_short Neuroprotective potential of Spirulina platensis on lesioned spinal cord corticospinal tract under experimental conditions in rat models
title_full Neuroprotective potential of Spirulina platensis on lesioned spinal cord corticospinal tract under experimental conditions in rat models
title_fullStr Neuroprotective potential of Spirulina platensis on lesioned spinal cord corticospinal tract under experimental conditions in rat models
title_full_unstemmed Neuroprotective potential of Spirulina platensis on lesioned spinal cord corticospinal tract under experimental conditions in rat models
title_sort neuroprotective potential of spirulina platensis on lesioned spinal cord corticospinal tract under experimental conditions in rat models
publisher Taylor & Francis
publishDate 2019
url http://eprints.um.edu.my/24274/
https://doi.org/10.1080/01913123.2019.1695693
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score 13.211869

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