Staff View: Re-Excision Rates in Breast-Conserving Surgery for Invasive Breast Cancer after Neoadjuvant Chemotherapy with and without the Use of a Radiopaque Tissue Transfer and X-ray System

Re-Excision Rates in Breast-Conserving Surgery for Invasive Breast Cancer after Neoadjuvant Chemotherapy with and without the Use of a Radiopaque Tissue Transfer and X-ray System

Background: Significant re-excision rates in breast-conserving surgery (BCS) after neoadjuvant systemic chemotherapy may result from difficulties in defining the surgical target particularly in cases with excellent treatment response. Devices allowing an exact topographic localisation of the lesion...

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Main Authors:	Jamaris, Suniza, Akpolat-Basci, Leyla, Stephanou, Miltiades, Wetzig, Sarah, Cubuk, Yueksel, Gerharz, Johannes, Bittner, Ann-Kathrin, See, Mee Hoong, Liedtke, Cornelia, Kolberg, Hans-Christian
Format:	Article
Published:	Karger Publishers 2018
Subjects:	R Medicine
Online Access:	http://eprints.um.edu.my/24128/ https://doi.org/10.1159/000493017
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spelling	my.um.eprints.241282020-03-31T16:39:06Z http://eprints.um.edu.my/24128/ Re-Excision Rates in Breast-Conserving Surgery for Invasive Breast Cancer after Neoadjuvant Chemotherapy with and without the Use of a Radiopaque Tissue Transfer and X-ray System Jamaris, Suniza Akpolat-Basci, Leyla Stephanou, Miltiades Wetzig, Sarah Cubuk, Yueksel Gerharz, Johannes Bittner, Ann-Kathrin See, Mee Hoong Liedtke, Cornelia Kolberg, Hans-Christian R Medicine Background: Significant re-excision rates in breast-conserving surgery (BCS) after neoadjuvant systemic chemotherapy may result from difficulties in defining the surgical target particularly in cases with excellent treatment response. Devices allowing an exact topographic localisation of the lesion in the resected tissue could reduce re-excision rates by optimising the intraoperative detection of involved margins. Methods: 80 patients with invasive breast cancer receiving BCS after neoadjuvant chemotherapy were included in this non-randomized case-control study. 40 patients with specimen radiography performed in a standard approach (control group) were compared to 40 patients with use of a radiopaque tissue transfer system (study group). Results: 19/80 (23.75%) patients required re-excision because of involved margins; among those, 14/40 (35%) were in the control group and 5/40 (12.5%) in the study group. The association between the use of the radiopaque tissue transfer system and the lower re-excision rate was statistically significant (p = 0.023). Conclusion: Our analysis provides a rationale for the routine use of a radiopaque tissue transfer system for specimen radiography in BCS after neoadjuvant chemotherapy for invasive breast cancer in order to reduce re-excision rates. © 2018 S. Karger AG, Basel. All rights reserved. Karger Publishers 2018 Article PeerReviewed Jamaris, Suniza and Akpolat-Basci, Leyla and Stephanou, Miltiades and Wetzig, Sarah and Cubuk, Yueksel and Gerharz, Johannes and Bittner, Ann-Kathrin and See, Mee Hoong and Liedtke, Cornelia and Kolberg, Hans-Christian (2018) Re-Excision Rates in Breast-Conserving Surgery for Invasive Breast Cancer after Neoadjuvant Chemotherapy with and without the Use of a Radiopaque Tissue Transfer and X-ray System. Breast Care, 14 (5). pp. 302-307. ISSN 1661-3791 https://doi.org/10.1159/000493017 doi:10.1159/000493017
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine
spellingShingle	R Medicine Jamaris, Suniza Akpolat-Basci, Leyla Stephanou, Miltiades Wetzig, Sarah Cubuk, Yueksel Gerharz, Johannes Bittner, Ann-Kathrin See, Mee Hoong Liedtke, Cornelia Kolberg, Hans-Christian Re-Excision Rates in Breast-Conserving Surgery for Invasive Breast Cancer after Neoadjuvant Chemotherapy with and without the Use of a Radiopaque Tissue Transfer and X-ray System
description	Background: Significant re-excision rates in breast-conserving surgery (BCS) after neoadjuvant systemic chemotherapy may result from difficulties in defining the surgical target particularly in cases with excellent treatment response. Devices allowing an exact topographic localisation of the lesion in the resected tissue could reduce re-excision rates by optimising the intraoperative detection of involved margins. Methods: 80 patients with invasive breast cancer receiving BCS after neoadjuvant chemotherapy were included in this non-randomized case-control study. 40 patients with specimen radiography performed in a standard approach (control group) were compared to 40 patients with use of a radiopaque tissue transfer system (study group). Results: 19/80 (23.75%) patients required re-excision because of involved margins; among those, 14/40 (35%) were in the control group and 5/40 (12.5%) in the study group. The association between the use of the radiopaque tissue transfer system and the lower re-excision rate was statistically significant (p = 0.023). Conclusion: Our analysis provides a rationale for the routine use of a radiopaque tissue transfer system for specimen radiography in BCS after neoadjuvant chemotherapy for invasive breast cancer in order to reduce re-excision rates. © 2018 S. Karger AG, Basel. All rights reserved.
format	Article
author	Jamaris, Suniza Akpolat-Basci, Leyla Stephanou, Miltiades Wetzig, Sarah Cubuk, Yueksel Gerharz, Johannes Bittner, Ann-Kathrin See, Mee Hoong Liedtke, Cornelia Kolberg, Hans-Christian
author_facet	Jamaris, Suniza Akpolat-Basci, Leyla Stephanou, Miltiades Wetzig, Sarah Cubuk, Yueksel Gerharz, Johannes Bittner, Ann-Kathrin See, Mee Hoong Liedtke, Cornelia Kolberg, Hans-Christian
author_sort	Jamaris, Suniza
title	Re-Excision Rates in Breast-Conserving Surgery for Invasive Breast Cancer after Neoadjuvant Chemotherapy with and without the Use of a Radiopaque Tissue Transfer and X-ray System
title_short	Re-Excision Rates in Breast-Conserving Surgery for Invasive Breast Cancer after Neoadjuvant Chemotherapy with and without the Use of a Radiopaque Tissue Transfer and X-ray System
title_full	Re-Excision Rates in Breast-Conserving Surgery for Invasive Breast Cancer after Neoadjuvant Chemotherapy with and without the Use of a Radiopaque Tissue Transfer and X-ray System
title_fullStr	Re-Excision Rates in Breast-Conserving Surgery for Invasive Breast Cancer after Neoadjuvant Chemotherapy with and without the Use of a Radiopaque Tissue Transfer and X-ray System
title_full_unstemmed	Re-Excision Rates in Breast-Conserving Surgery for Invasive Breast Cancer after Neoadjuvant Chemotherapy with and without the Use of a Radiopaque Tissue Transfer and X-ray System
title_sort	re-excision rates in breast-conserving surgery for invasive breast cancer after neoadjuvant chemotherapy with and without the use of a radiopaque tissue transfer and x-ray system
publisher	Karger Publishers
publishDate	2018
url	http://eprints.um.edu.my/24128/ https://doi.org/10.1159/000493017
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score	13.211869

Re-Excision Rates in Breast-Conserving Surgery for Invasive Breast Cancer after Neoadjuvant Chemotherapy with and without the Use of a Radiopaque Tissue Transfer and X-ray System

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