Staff View: A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules

A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules

The different states of water incorporated in wet granules were studied by a low-field benchtop 1H-NMR time-domain NMR (TD-NMR) instrument. Wet granules consisting different fillers [cornstarch (CS), microcrystalline cellulose (MCC), and D-mannitol (MAN)] with different water contents were prepared...

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Main Authors:	Ito, Terushi, Okada, Kotaro, Leong, Kok Hoong, Hirai, Daijiro, Hayashi, Yoshihiro, Kumada, Shungo, Kosugi, Atsushi, Onuki, Yoshinori
Format:	Article
Published:	Pharmaceutical Society of Japan 2019
Subjects:	R Medicine RS Pharmacy and materia medica
Online Access:	http://eprints.um.edu.my/24102/ https://doi.org/10.1248/cpb.c18-00888
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spelling	my.um.eprints.241022020-03-26T04:43:29Z http://eprints.um.edu.my/24102/ A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules Ito, Terushi Okada, Kotaro Leong, Kok Hoong Hirai, Daijiro Hayashi, Yoshihiro Kumada, Shungo Kosugi, Atsushi Onuki, Yoshinori R Medicine RS Pharmacy and materia medica The different states of water incorporated in wet granules were studied by a low-field benchtop 1H-NMR time-domain NMR (TD-NMR) instrument. Wet granules consisting different fillers [cornstarch (CS), microcrystalline cellulose (MCC), and D-mannitol (MAN)] with different water contents were prepared using a high-speed granulator, and then their spin–spin relaxation time (T2) was measured using the NMR relaxation technique. The experimental T2 relaxation curves were analyzed by the two-component curve fitting, and then the individual T2 relaxation behaviors of solid and water in wet granules were identified. According to the observed T2 values, it was confirmed that the molecular mobility of water in CS and MCC granules was more restricted than that in the MAN granule. The state of water appeared to be associated with the drying efficiency and moisture absorption capacity of wet granules. Thus, it was confirmed that the state of water significantly affected the wet granulation process and the characteristics of the resultant granules. In the final phase of this study, the effects of binders on the molecular mobility of water in granulation fluids and wet granules were examined. The state of water in granulation fluids was substantially changed by changing the binders. The difference was still detected in wet granules prepared by addition of these fluids to the fillers. In conclusion, TD-NMR can offer valuable knowledge on wet granulation from the viewpoint of molecular mobility of water. © 2019 The Pharmaceutical Society of Japan. Pharmaceutical Society of Japan 2019 Article PeerReviewed Ito, Terushi and Okada, Kotaro and Leong, Kok Hoong and Hirai, Daijiro and Hayashi, Yoshihiro and Kumada, Shungo and Kosugi, Atsushi and Onuki, Yoshinori (2019) A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules. Chemical and Pharmaceutical Bulletin, 67 (3). pp. 271-276. ISSN 0009-2363 https://doi.org/10.1248/cpb.c18-00888 doi:10.1248/cpb.c18-00888
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine RS Pharmacy and materia medica
spellingShingle	R Medicine RS Pharmacy and materia medica Ito, Terushi Okada, Kotaro Leong, Kok Hoong Hirai, Daijiro Hayashi, Yoshihiro Kumada, Shungo Kosugi, Atsushi Onuki, Yoshinori A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules
description	The different states of water incorporated in wet granules were studied by a low-field benchtop 1H-NMR time-domain NMR (TD-NMR) instrument. Wet granules consisting different fillers [cornstarch (CS), microcrystalline cellulose (MCC), and D-mannitol (MAN)] with different water contents were prepared using a high-speed granulator, and then their spin–spin relaxation time (T2) was measured using the NMR relaxation technique. The experimental T2 relaxation curves were analyzed by the two-component curve fitting, and then the individual T2 relaxation behaviors of solid and water in wet granules were identified. According to the observed T2 values, it was confirmed that the molecular mobility of water in CS and MCC granules was more restricted than that in the MAN granule. The state of water appeared to be associated with the drying efficiency and moisture absorption capacity of wet granules. Thus, it was confirmed that the state of water significantly affected the wet granulation process and the characteristics of the resultant granules. In the final phase of this study, the effects of binders on the molecular mobility of water in granulation fluids and wet granules were examined. The state of water in granulation fluids was substantially changed by changing the binders. The difference was still detected in wet granules prepared by addition of these fluids to the fillers. In conclusion, TD-NMR can offer valuable knowledge on wet granulation from the viewpoint of molecular mobility of water. © 2019 The Pharmaceutical Society of Japan.
format	Article
author	Ito, Terushi Okada, Kotaro Leong, Kok Hoong Hirai, Daijiro Hayashi, Yoshihiro Kumada, Shungo Kosugi, Atsushi Onuki, Yoshinori
author_facet	Ito, Terushi Okada, Kotaro Leong, Kok Hoong Hirai, Daijiro Hayashi, Yoshihiro Kumada, Shungo Kosugi, Atsushi Onuki, Yoshinori
author_sort	Ito, Terushi
title	A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules
title_short	A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules
title_full	A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules
title_fullStr	A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules
title_full_unstemmed	A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules
title_sort	time-domain nmr study of the state of water in wet granules with different fillers and its contribution to the wet granulation process and to the characteristics of granules
publisher	Pharmaceutical Society of Japan
publishDate	2019
url	http://eprints.um.edu.my/24102/ https://doi.org/10.1248/cpb.c18-00888
_version_	1662755223306764288
score	13.211869

A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules

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