Population pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young infants
OBJECTIVES: In the absence of consensus, the present meta-analysis was performed to determine an optimal dosing regimen of vancomycin for neonates. METHODS: A 'meta-model' with 4894 concentrations from 1631 neonates was built using NONMEM, and Monte Carlo simulations were performed to desi...
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| Main Authors: | , , , , , , , , , , , , , , , , |
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| 格式: | Article |
| 出版: |
Oxford University Press
2019
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| 主题: | |
| 在线阅读: | http://eprints.um.edu.my/24098/ https://doi.org/10.1093/jac/dkz158 |
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