Staff View: Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice

Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice

The interaction between natural occurring inhibitors and targeted membrane proteins could be an alternative medicinal strategy for the treatment of metabolic syndrome, notably, obesity. In this study, we identified malabaricones A-C and E (1-4) isolated from the fruits of Myristica cinnamomea King a...

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Main Authors:	Othman, Muhamad Aqmal, Yuyama, Kohei, Murai, Yuta, Igarashi, Yasuyuki, Mikami, Daisuke, Sivasothy, Yasodha, Awang, Khalijah, Monde, Kenji
Format:	Article
Published:	American Chemical Society 2019
Subjects:	Q Science (General) QD Chemistry
Online Access:	http://eprints.um.edu.my/23781/ https://doi.org/10.1021/acsmedchemlett.9b00171
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id	my.um.eprints.23781
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spelling	my.um.eprints.237812020-02-13T02:52:57Z http://eprints.um.edu.my/23781/ Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice Othman, Muhamad Aqmal Yuyama, Kohei Murai, Yuta Igarashi, Yasuyuki Mikami, Daisuke Sivasothy, Yasodha Awang, Khalijah Monde, Kenji Q Science (General) QD Chemistry The interaction between natural occurring inhibitors and targeted membrane proteins could be an alternative medicinal strategy for the treatment of metabolic syndrome, notably, obesity. In this study, we identified malabaricones A-C and E (1-4) isolated from the fruits of Myristica cinnamomea King as natural inhibitors for sphingomyelin synthase (SMS), a membrane protein responsible for sphingolipid biosynthesis. Having the most promising inhibition, oral administration of compound 3 exhibited multiple efficacies in reducing weight gain, improving glucose tolerance, and reducing hepatic steatosis in high fat diet-induced obesity mice models. Liver lipid analysis revealed a crucial link between the SMS activities of compound 3 and its lipid metabolism in vitro and in vivo. The nontoxic nature of compound 3 makes it a suitable candidate in search of drugs which can be employed in the treatment and prevention of obesity. © 2019 American Chemical Society. American Chemical Society 2019 Article PeerReviewed Othman, Muhamad Aqmal and Yuyama, Kohei and Murai, Yuta and Igarashi, Yasuyuki and Mikami, Daisuke and Sivasothy, Yasodha and Awang, Khalijah and Monde, Kenji (2019) Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice. ACS Medicinal Chemistry Letters, 10 (8). pp. 1154-1158. ISSN 1948-5875 https://doi.org/10.1021/acsmedchemlett.9b00171 doi:10.1021/acsmedchemlett.9b00171
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	Q Science (General) QD Chemistry
spellingShingle	Q Science (General) QD Chemistry Othman, Muhamad Aqmal Yuyama, Kohei Murai, Yuta Igarashi, Yasuyuki Mikami, Daisuke Sivasothy, Yasodha Awang, Khalijah Monde, Kenji Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice
description	The interaction between natural occurring inhibitors and targeted membrane proteins could be an alternative medicinal strategy for the treatment of metabolic syndrome, notably, obesity. In this study, we identified malabaricones A-C and E (1-4) isolated from the fruits of Myristica cinnamomea King as natural inhibitors for sphingomyelin synthase (SMS), a membrane protein responsible for sphingolipid biosynthesis. Having the most promising inhibition, oral administration of compound 3 exhibited multiple efficacies in reducing weight gain, improving glucose tolerance, and reducing hepatic steatosis in high fat diet-induced obesity mice models. Liver lipid analysis revealed a crucial link between the SMS activities of compound 3 and its lipid metabolism in vitro and in vivo. The nontoxic nature of compound 3 makes it a suitable candidate in search of drugs which can be employed in the treatment and prevention of obesity. © 2019 American Chemical Society.
format	Article
author	Othman, Muhamad Aqmal Yuyama, Kohei Murai, Yuta Igarashi, Yasuyuki Mikami, Daisuke Sivasothy, Yasodha Awang, Khalijah Monde, Kenji
author_facet	Othman, Muhamad Aqmal Yuyama, Kohei Murai, Yuta Igarashi, Yasuyuki Mikami, Daisuke Sivasothy, Yasodha Awang, Khalijah Monde, Kenji
author_sort	Othman, Muhamad Aqmal
title	Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice
title_short	Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice
title_full	Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice
title_fullStr	Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice
title_full_unstemmed	Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice
title_sort	malabaricone c as natural sphingomyelin synthase inhibitor against diet-induced obesity and its lipid metabolism in mice
publisher	American Chemical Society
publishDate	2019
url	http://eprints.um.edu.my/23781/ https://doi.org/10.1021/acsmedchemlett.9b00171
_version_	1662755179045322752
score	13.211869

Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice

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