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Facile synthesis of silver nanoparticles using Averrhoa bilimbi L and Plum extracts and investigation on the synergistic bioactivity using in vitro models

The bacterial communities (Gram-negative and Gram-positive) form the biofilms which oppose the mode of action of antibiotics and affecting the immune system of the human. These chronic infections related to biofilm are always hard to be cured because of their inherent resistance to both antimicrobia...

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Main Authors:	Sagadevan, Suresh, Vennila, Selvaraj, Singh, Preeti, Lett, Jayasingh Anita, Johan, Mohd Rafie, Marlinda, Ab Rahman, Muthiah, Bavanilatha, Lakshmipathy, Muthukrishnan
Format:	Article
Published:	De Gruyter 2019
Subjects:	QC Physics TK Electrical engineering. Electronics Nuclear engineering TP Chemical technology
Online Access:	http://eprints.um.edu.my/23596/ https://doi.org/10.1515/gps-2019-0058
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spelling	my.um.eprints.235962020-01-28T02:18:26Z http://eprints.um.edu.my/23596/ Facile synthesis of silver nanoparticles using Averrhoa bilimbi L and Plum extracts and investigation on the synergistic bioactivity using in vitro models Sagadevan, Suresh Vennila, Selvaraj Singh, Preeti Lett, Jayasingh Anita Johan, Mohd Rafie Marlinda, Ab Rahman Muthiah, Bavanilatha Lakshmipathy, Muthukrishnan QC Physics TK Electrical engineering. Electronics Nuclear engineering TP Chemical technology The bacterial communities (Gram-negative and Gram-positive) form the biofilms which oppose the mode of action of antibiotics and affecting the immune system of the human. These chronic infections related to biofilm are always hard to be cured because of their inherent resistance to both antimicrobial agents and host defense. The present study is devoted to the synthesis of silver nanoparticles (AgNPs) using aqueous extracts of Averrhoa bilimbi leaf and Plum fruit (Prunus bokharensis) and its inhibitory effect on Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Salmonella typhi. Here, AgNPs) were successfully prepared by green synthesis method obtained by the reduction of silver nitrate into silver ions. The synthesized AgNPs were characterized by UV-Vis Spectroscopy, XRD, FTIR, FESEM-EDAX and DLS analysis. The antimicrobial effects of the two extract were evaluated by the disk diffusion method. The green synthesized AgNPs exhibited good antibacterial activity against both Gram-negative and Gram-positive. They were also analyzed for their significant antibacterial activities against all the test cultures exposed whereas Escherichia coli and Salmonella typhi topped among other test cultures. The anti-proliferative activity of phytochemical mediated synthesis of Ag NPs was investigated for their cytotoxicity in Vero and Human epidermoid larynx carcinoma cell lines (HEp-2) based on their viability using MTT assay. The present study also represents the synergistic bioactivity of silver nanoparticles using in vitro models. © 2019 Sagadevan et al., published by De Gruyter. De Gruyter 2019 Article PeerReviewed Sagadevan, Suresh and Vennila, Selvaraj and Singh, Preeti and Lett, Jayasingh Anita and Johan, Mohd Rafie and Marlinda, Ab Rahman and Muthiah, Bavanilatha and Lakshmipathy, Muthukrishnan (2019) Facile synthesis of silver nanoparticles using Averrhoa bilimbi L and Plum extracts and investigation on the synergistic bioactivity using in vitro models. Green Processing and Synthesis, 8 (1). pp. 873-884. ISSN 2191-9542 https://doi.org/10.1515/gps-2019-0058 doi:10.1515/gps-2019-0058
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	QC Physics TK Electrical engineering. Electronics Nuclear engineering TP Chemical technology
spellingShingle	QC Physics TK Electrical engineering. Electronics Nuclear engineering TP Chemical technology Sagadevan, Suresh Vennila, Selvaraj Singh, Preeti Lett, Jayasingh Anita Johan, Mohd Rafie Marlinda, Ab Rahman Muthiah, Bavanilatha Lakshmipathy, Muthukrishnan Facile synthesis of silver nanoparticles using Averrhoa bilimbi L and Plum extracts and investigation on the synergistic bioactivity using in vitro models
description	The bacterial communities (Gram-negative and Gram-positive) form the biofilms which oppose the mode of action of antibiotics and affecting the immune system of the human. These chronic infections related to biofilm are always hard to be cured because of their inherent resistance to both antimicrobial agents and host defense. The present study is devoted to the synthesis of silver nanoparticles (AgNPs) using aqueous extracts of Averrhoa bilimbi leaf and Plum fruit (Prunus bokharensis) and its inhibitory effect on Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Salmonella typhi. Here, AgNPs) were successfully prepared by green synthesis method obtained by the reduction of silver nitrate into silver ions. The synthesized AgNPs were characterized by UV-Vis Spectroscopy, XRD, FTIR, FESEM-EDAX and DLS analysis. The antimicrobial effects of the two extract were evaluated by the disk diffusion method. The green synthesized AgNPs exhibited good antibacterial activity against both Gram-negative and Gram-positive. They were also analyzed for their significant antibacterial activities against all the test cultures exposed whereas Escherichia coli and Salmonella typhi topped among other test cultures. The anti-proliferative activity of phytochemical mediated synthesis of Ag NPs was investigated for their cytotoxicity in Vero and Human epidermoid larynx carcinoma cell lines (HEp-2) based on their viability using MTT assay. The present study also represents the synergistic bioactivity of silver nanoparticles using in vitro models. © 2019 Sagadevan et al., published by De Gruyter.
format	Article
author	Sagadevan, Suresh Vennila, Selvaraj Singh, Preeti Lett, Jayasingh Anita Johan, Mohd Rafie Marlinda, Ab Rahman Muthiah, Bavanilatha Lakshmipathy, Muthukrishnan
author_facet	Sagadevan, Suresh Vennila, Selvaraj Singh, Preeti Lett, Jayasingh Anita Johan, Mohd Rafie Marlinda, Ab Rahman Muthiah, Bavanilatha Lakshmipathy, Muthukrishnan
author_sort	Sagadevan, Suresh
title	Facile synthesis of silver nanoparticles using Averrhoa bilimbi L and Plum extracts and investigation on the synergistic bioactivity using in vitro models
title_short	Facile synthesis of silver nanoparticles using Averrhoa bilimbi L and Plum extracts and investigation on the synergistic bioactivity using in vitro models
title_full	Facile synthesis of silver nanoparticles using Averrhoa bilimbi L and Plum extracts and investigation on the synergistic bioactivity using in vitro models
title_fullStr	Facile synthesis of silver nanoparticles using Averrhoa bilimbi L and Plum extracts and investigation on the synergistic bioactivity using in vitro models
title_full_unstemmed	Facile synthesis of silver nanoparticles using Averrhoa bilimbi L and Plum extracts and investigation on the synergistic bioactivity using in vitro models
title_sort	facile synthesis of silver nanoparticles using averrhoa bilimbi l and plum extracts and investigation on the synergistic bioactivity using in vitro models
publisher	De Gruyter
publishDate	2019
url	http://eprints.um.edu.my/23596/ https://doi.org/10.1515/gps-2019-0058
_version_	1657488232931131392
score	13.211869

Facile synthesis of silver nanoparticles using Averrhoa bilimbi L and Plum extracts and investigation on the synergistic bioactivity using in vitro models

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