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Perception of Stigma and Its Associated Factors Among Patients With Major Depressive Disorder: A Multicenter Survey From an Asian Population

Stigma of major depressive disorder (MDD) is an important public health problem. This study aimed to examine the level of perceived stigma and its associated factors in MDD patients in five Asian countries, including China, Korea, Malaysia, Singapore, and Thailand. A total of 547 outpatients with MD...

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Main Authors: Sun, Yan, Chen, Gang, Wang, Li, Li, Nan, Srisurapanont, Manit, Hong, Jin Pyo, Sulaiman, Ahmad Hatim, Chen, Chia-hui, Udomratn, Pichet, Bae, Jae Nam, Fang, Yi-Ru, Chua, Hong Choon, Liu, Shen-Ing, George, Tom, Bautista, Dianne, Chan, Edwin, Rush, A. John, Yang, Hong, Su, Yun-Ai, Si, Tian-Mei
Format: Article
Published: Frontiers Media 2019
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R Medicine
Online Access:http://eprints.um.edu.my/23366/
https://doi.org/10.3389/fpsyt.2019.00321
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spelling my.um.eprints.233662020-01-09T02:30:49Z http://eprints.um.edu.my/23366/ Perception of Stigma and Its Associated Factors Among Patients With Major Depressive Disorder: A Multicenter Survey From an Asian Population Sun, Yan Chen, Gang Wang, Li Li, Nan Srisurapanont, Manit Hong, Jin Pyo Sulaiman, Ahmad Hatim Chen, Chia-hui Udomratn, Pichet Bae, Jae Nam Fang, Yi-Ru Chua, Hong Choon Liu, Shen-Ing George, Tom Bautista, Dianne Chan, Edwin Rush, A. John Yang, Hong Su, Yun-Ai Si, Tian-Mei R Medicine Stigma of major depressive disorder (MDD) is an important public health problem. This study aimed to examine the level of perceived stigma and its associated factors in MDD patients in five Asian countries, including China, Korea, Malaysia, Singapore, and Thailand. A total of 547 outpatients with MDD were included from Asian countries. We used the stigma scale of the Explanatory Model Interview Catalogue (EMIC) to assess stigma. The Montgomery-Asberg Depression Rating Scale (MADRS), Symptoms Checklist 90-Revised (SCL-90-R), Fatigue Severity Scale (FSS), Sheehan Disability Scale (SDS), 36-Item Short-Form Health Survey (SF-36), and Multidimensional Scale of Perceived Social Support (MSPSS) were used to assess symptoms, clinical features, functional impairment, health status, and social support. The stigma scores of patients under 55 years old were significantly higher than those equal to or greater than 55 years old (P < 0.001). The stigma scores exhibited significant negative correlation with age; MSPSS scores of family, friends, and others; and SF-36 subscale of mental health, but significant positive correlation with MADRS, FSS, SDS, and SCL-90-R subscale scores of depression, interpersonal sensitivity, obsession-compulsion, psychoticism, and somatization. Multivariate regression analysis revealed that age, SCL-90-R interpersonal sensitivity, obsession-compulsion, psychoticism, MSPSS scores of friends and others, and SF-36 of mental health were significantly associated with the level of perceived stigma. These findings suggest that MDD patients who are young, have a high degree of interpersonal sensitivity and psychoticism, have low health-related quality of life, and have low social support are the target population for stigma interventions in Asia. © 2019 Sun, Chen, Wang, Li, Srisurapanont, Hong, Hatim, Chen, Udomratn, Bae, Fang, Chua, Liu, George, Bautista, Chan, Rush, Yang, Su and Si. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Frontiers Media 2019 Article PeerReviewed Sun, Yan and Chen, Gang and Wang, Li and Li, Nan and Srisurapanont, Manit and Hong, Jin Pyo and Sulaiman, Ahmad Hatim and Chen, Chia-hui and Udomratn, Pichet and Bae, Jae Nam and Fang, Yi-Ru and Chua, Hong Choon and Liu, Shen-Ing and George, Tom and Bautista, Dianne and Chan, Edwin and Rush, A. John and Yang, Hong and Su, Yun-Ai and Si, Tian-Mei (2019) Perception of Stigma and Its Associated Factors Among Patients With Major Depressive Disorder: A Multicenter Survey From an Asian Population. Frontiers in Psychiatry, 10. p. 321. ISSN 1664-0640 https://doi.org/10.3389/fpsyt.2019.00321 doi:10.3389/fpsyt.2019.00321
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Sun, Yan
Chen, Gang
Wang, Li
Li, Nan
Srisurapanont, Manit
Hong, Jin Pyo
Sulaiman, Ahmad Hatim
Chen, Chia-hui
Udomratn, Pichet
Bae, Jae Nam
Fang, Yi-Ru
Chua, Hong Choon
Liu, Shen-Ing
George, Tom
Bautista, Dianne
Chan, Edwin
Rush, A. John
Yang, Hong
Su, Yun-Ai
Si, Tian-Mei
Perception of Stigma and Its Associated Factors Among Patients With Major Depressive Disorder: A Multicenter Survey From an Asian Population
description Stigma of major depressive disorder (MDD) is an important public health problem. This study aimed to examine the level of perceived stigma and its associated factors in MDD patients in five Asian countries, including China, Korea, Malaysia, Singapore, and Thailand. A total of 547 outpatients with MDD were included from Asian countries. We used the stigma scale of the Explanatory Model Interview Catalogue (EMIC) to assess stigma. The Montgomery-Asberg Depression Rating Scale (MADRS), Symptoms Checklist 90-Revised (SCL-90-R), Fatigue Severity Scale (FSS), Sheehan Disability Scale (SDS), 36-Item Short-Form Health Survey (SF-36), and Multidimensional Scale of Perceived Social Support (MSPSS) were used to assess symptoms, clinical features, functional impairment, health status, and social support. The stigma scores of patients under 55 years old were significantly higher than those equal to or greater than 55 years old (P < 0.001). The stigma scores exhibited significant negative correlation with age; MSPSS scores of family, friends, and others; and SF-36 subscale of mental health, but significant positive correlation with MADRS, FSS, SDS, and SCL-90-R subscale scores of depression, interpersonal sensitivity, obsession-compulsion, psychoticism, and somatization. Multivariate regression analysis revealed that age, SCL-90-R interpersonal sensitivity, obsession-compulsion, psychoticism, MSPSS scores of friends and others, and SF-36 of mental health were significantly associated with the level of perceived stigma. These findings suggest that MDD patients who are young, have a high degree of interpersonal sensitivity and psychoticism, have low health-related quality of life, and have low social support are the target population for stigma interventions in Asia. © 2019 Sun, Chen, Wang, Li, Srisurapanont, Hong, Hatim, Chen, Udomratn, Bae, Fang, Chua, Liu, George, Bautista, Chan, Rush, Yang, Su and Si. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
format Article
author Sun, Yan
Chen, Gang
Wang, Li
Li, Nan
Srisurapanont, Manit
Hong, Jin Pyo
Sulaiman, Ahmad Hatim
Chen, Chia-hui
Udomratn, Pichet
Bae, Jae Nam
Fang, Yi-Ru
Chua, Hong Choon
Liu, Shen-Ing
George, Tom
Bautista, Dianne
Chan, Edwin
Rush, A. John
Yang, Hong
Su, Yun-Ai
Si, Tian-Mei
author_facet Sun, Yan
Chen, Gang
Wang, Li
Li, Nan
Srisurapanont, Manit
Hong, Jin Pyo
Sulaiman, Ahmad Hatim
Chen, Chia-hui
Udomratn, Pichet
Bae, Jae Nam
Fang, Yi-Ru
Chua, Hong Choon
Liu, Shen-Ing
George, Tom
Bautista, Dianne
Chan, Edwin
Rush, A. John
Yang, Hong
Su, Yun-Ai
Si, Tian-Mei
author_sort Sun, Yan
title Perception of Stigma and Its Associated Factors Among Patients With Major Depressive Disorder: A Multicenter Survey From an Asian Population
title_short Perception of Stigma and Its Associated Factors Among Patients With Major Depressive Disorder: A Multicenter Survey From an Asian Population
title_full Perception of Stigma and Its Associated Factors Among Patients With Major Depressive Disorder: A Multicenter Survey From an Asian Population
title_fullStr Perception of Stigma and Its Associated Factors Among Patients With Major Depressive Disorder: A Multicenter Survey From an Asian Population
title_full_unstemmed Perception of Stigma and Its Associated Factors Among Patients With Major Depressive Disorder: A Multicenter Survey From an Asian Population
title_sort perception of stigma and its associated factors among patients with major depressive disorder: a multicenter survey from an asian population
publisher Frontiers Media
publishDate 2019
url http://eprints.um.edu.my/23366/
https://doi.org/10.3389/fpsyt.2019.00321
_version_ 1657488198724485120
score 13.211869

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