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Evaluating the physicochemical properties and efficacy of recently expired and aged antivenom products from Thailand and Taiwan

Gel filtration chromatography and gel electrophoresis revealed minimal protein degradation in lyophilized antivenoms which were 2-year expired (Hemato Polyvalent, Neuro Polyvalent; Thailand) and 18-year expired (Hemato Bivalent, Neuro Bivalent; Taiwan). All expired antivenoms retained immunological...

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Main Authors:	Tan, Kae Yi, Liew, Sin Teng, Tan, Qian Yi, Abdul-Rahman, Farah Nadhirah, Azmi, Nor Izzati, Sim, Si Mui, Tan, Nget Hong, Khomvilai, Sumana, Sitprija, Visith, Tan, Choo Hock
Format:	Article
Published:	Elsevier 2019
Subjects:	R Medicine
Online Access:	http://eprints.um.edu.my/23302/ https://doi.org/10.1016/j.toxicon.2019.02.010
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id	my.um.eprints.23302
record_format	eprints
spelling	my.um.eprints.233022020-01-03T05:54:46Z http://eprints.um.edu.my/23302/ Evaluating the physicochemical properties and efficacy of recently expired and aged antivenom products from Thailand and Taiwan Tan, Kae Yi Liew, Sin Teng Tan, Qian Yi Abdul-Rahman, Farah Nadhirah Azmi, Nor Izzati Sim, Si Mui Tan, Nget Hong Khomvilai, Sumana Sitprija, Visith Tan, Choo Hock R Medicine Gel filtration chromatography and gel electrophoresis revealed minimal protein degradation in lyophilized antivenoms which were 2-year expired (Hemato Polyvalent, Neuro Polyvalent; Thailand) and 18-year expired (Hemato Bivalent, Neuro Bivalent; Taiwan). All expired antivenoms retained immunological binding activity, and were able to neutralize the hemotoxic or neurotoxic as well as lethal effects of the homologous snake venoms. The findings show that antivenoms under proper storage conditions may remain relatively stable beyond the indicated shelf life. © 2019 Elsevier Ltd Elsevier 2019 Article PeerReviewed Tan, Kae Yi and Liew, Sin Teng and Tan, Qian Yi and Abdul-Rahman, Farah Nadhirah and Azmi, Nor Izzati and Sim, Si Mui and Tan, Nget Hong and Khomvilai, Sumana and Sitprija, Visith and Tan, Choo Hock (2019) Evaluating the physicochemical properties and efficacy of recently expired and aged antivenom products from Thailand and Taiwan. Toxicon, 160. pp. 55-58. ISSN 0041-0101 https://doi.org/10.1016/j.toxicon.2019.02.010 doi:10.1016/j.toxicon.2019.02.010
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine
spellingShingle	R Medicine Tan, Kae Yi Liew, Sin Teng Tan, Qian Yi Abdul-Rahman, Farah Nadhirah Azmi, Nor Izzati Sim, Si Mui Tan, Nget Hong Khomvilai, Sumana Sitprija, Visith Tan, Choo Hock Evaluating the physicochemical properties and efficacy of recently expired and aged antivenom products from Thailand and Taiwan
description	Gel filtration chromatography and gel electrophoresis revealed minimal protein degradation in lyophilized antivenoms which were 2-year expired (Hemato Polyvalent, Neuro Polyvalent; Thailand) and 18-year expired (Hemato Bivalent, Neuro Bivalent; Taiwan). All expired antivenoms retained immunological binding activity, and were able to neutralize the hemotoxic or neurotoxic as well as lethal effects of the homologous snake venoms. The findings show that antivenoms under proper storage conditions may remain relatively stable beyond the indicated shelf life. © 2019 Elsevier Ltd
format	Article
author	Tan, Kae Yi Liew, Sin Teng Tan, Qian Yi Abdul-Rahman, Farah Nadhirah Azmi, Nor Izzati Sim, Si Mui Tan, Nget Hong Khomvilai, Sumana Sitprija, Visith Tan, Choo Hock
author_facet	Tan, Kae Yi Liew, Sin Teng Tan, Qian Yi Abdul-Rahman, Farah Nadhirah Azmi, Nor Izzati Sim, Si Mui Tan, Nget Hong Khomvilai, Sumana Sitprija, Visith Tan, Choo Hock
author_sort	Tan, Kae Yi
title	Evaluating the physicochemical properties and efficacy of recently expired and aged antivenom products from Thailand and Taiwan
title_short	Evaluating the physicochemical properties and efficacy of recently expired and aged antivenom products from Thailand and Taiwan
title_full	Evaluating the physicochemical properties and efficacy of recently expired and aged antivenom products from Thailand and Taiwan
title_fullStr	Evaluating the physicochemical properties and efficacy of recently expired and aged antivenom products from Thailand and Taiwan
title_full_unstemmed	Evaluating the physicochemical properties and efficacy of recently expired and aged antivenom products from Thailand and Taiwan
title_sort	evaluating the physicochemical properties and efficacy of recently expired and aged antivenom products from thailand and taiwan
publisher	Elsevier
publishDate	2019
url	http://eprints.um.edu.my/23302/ https://doi.org/10.1016/j.toxicon.2019.02.010
_version_	1654960714385719296
score	13.211869

Evaluating the physicochemical properties and efficacy of recently expired and aged antivenom products from Thailand and Taiwan

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