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Design and numerical analysis of interdigitated radiating-strips electrode for uniform 3D dielectrophoretic patterning of liver cells

This paper presents the design and numerical analysis of a new three-dimensional (3D) electrode having a non-uniform electric field gradient for dielectrophoretic patterning of liver cells. The strength of the dielectrophoresis (DEP) force is influenced by the gradient of electric field generated by...

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Main Authors: Yahya, Wan Nurlina Wan, Kadri, Nahrizul Adib, Ibrahim, Fatimah
Format: Article
Published: Springer Verlag (Germany) 2019
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/23131/
https://doi.org/10.1007/s00542-018-4258-7
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spelling my.um.eprints.231312019-11-27T08:56:11Z http://eprints.um.edu.my/23131/ Design and numerical analysis of interdigitated radiating-strips electrode for uniform 3D dielectrophoretic patterning of liver cells Yahya, Wan Nurlina Wan Kadri, Nahrizul Adib Ibrahim, Fatimah R Medicine This paper presents the design and numerical analysis of a new three-dimensional (3D) electrode having a non-uniform electric field gradient for dielectrophoretic patterning of liver cells. The strength of the dielectrophoresis (DEP) force is influenced by the gradient of electric field generated by the electrode. The new design of the 3D electrode with two different electrode configurations were first modelled and simulated using COMSOL Multiphysics. Results show that the electrical field distribution of vertical configuration concentrated only on the end strips and decays progressively towards the centre while the horizontal configuration shows a more uniform electric field distribution with minimal decrease of the electric field towards the centre. Besides, the horizontal configuration offered 2.7 times higher of the electrical field strength to establish the 3D DEP force hence the 3D cellular pattern. Thus, the electrode with the horizontal configuration has been proposed and optimized to be fabricated for the cell patterning application later on. The optimum electrode dimension identified in this work was 20 µm: 50 µm (gap: height) with a 20 µm electrode width that generates a maximum value of 1.06 × 106 V/m with a voltage set at 5 V. Increasing voltage leads to a stronger electric field and more DEP force would be imposed on the cells. This findings support that the unique design of the 3D electrode can further be used for dielectrophoretic-based patterning mechanism specifically for the complex liver tissue engineering. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature. Springer Verlag (Germany) 2019 Article PeerReviewed Yahya, Wan Nurlina Wan and Kadri, Nahrizul Adib and Ibrahim, Fatimah (2019) Design and numerical analysis of interdigitated radiating-strips electrode for uniform 3D dielectrophoretic patterning of liver cells. Microsystem Technologies, 25 (8). pp. 3037-3045. ISSN 0946-7076 https://doi.org/10.1007/s00542-018-4258-7 doi:10.1007/s00542-018-4258-7
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Yahya, Wan Nurlina Wan
Kadri, Nahrizul Adib
Ibrahim, Fatimah
Design and numerical analysis of interdigitated radiating-strips electrode for uniform 3D dielectrophoretic patterning of liver cells
description This paper presents the design and numerical analysis of a new three-dimensional (3D) electrode having a non-uniform electric field gradient for dielectrophoretic patterning of liver cells. The strength of the dielectrophoresis (DEP) force is influenced by the gradient of electric field generated by the electrode. The new design of the 3D electrode with two different electrode configurations were first modelled and simulated using COMSOL Multiphysics. Results show that the electrical field distribution of vertical configuration concentrated only on the end strips and decays progressively towards the centre while the horizontal configuration shows a more uniform electric field distribution with minimal decrease of the electric field towards the centre. Besides, the horizontal configuration offered 2.7 times higher of the electrical field strength to establish the 3D DEP force hence the 3D cellular pattern. Thus, the electrode with the horizontal configuration has been proposed and optimized to be fabricated for the cell patterning application later on. The optimum electrode dimension identified in this work was 20 µm: 50 µm (gap: height) with a 20 µm electrode width that generates a maximum value of 1.06 × 106 V/m with a voltage set at 5 V. Increasing voltage leads to a stronger electric field and more DEP force would be imposed on the cells. This findings support that the unique design of the 3D electrode can further be used for dielectrophoretic-based patterning mechanism specifically for the complex liver tissue engineering. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
format Article
author Yahya, Wan Nurlina Wan
Kadri, Nahrizul Adib
Ibrahim, Fatimah
author_facet Yahya, Wan Nurlina Wan
Kadri, Nahrizul Adib
Ibrahim, Fatimah
author_sort Yahya, Wan Nurlina Wan
title Design and numerical analysis of interdigitated radiating-strips electrode for uniform 3D dielectrophoretic patterning of liver cells
title_short Design and numerical analysis of interdigitated radiating-strips electrode for uniform 3D dielectrophoretic patterning of liver cells
title_full Design and numerical analysis of interdigitated radiating-strips electrode for uniform 3D dielectrophoretic patterning of liver cells
title_fullStr Design and numerical analysis of interdigitated radiating-strips electrode for uniform 3D dielectrophoretic patterning of liver cells
title_full_unstemmed Design and numerical analysis of interdigitated radiating-strips electrode for uniform 3D dielectrophoretic patterning of liver cells
title_sort design and numerical analysis of interdigitated radiating-strips electrode for uniform 3d dielectrophoretic patterning of liver cells
publisher Springer Verlag (Germany)
publishDate 2019
url http://eprints.um.edu.my/23131/
https://doi.org/10.1007/s00542-018-4258-7
_version_ 1651867404394823680
score 13.250461

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