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Gender differences in reduced substance P (SP) in children with slow-transit constipation

Purpose: Adult slow-transit constipation (STC) occurs predominantly in females and is associated with low numbers of substance P (SP)-containing nerves in colonic circular muscle. Aim: To determine if reduced SP nerves is female predominant in paediatric STC. Methods: Children with STC were identifi...

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Main Authors: Yik, Yee Ian, Farmer, Pamela J., King, Sebastian K., Chow, C.W., Hutson, John M., Southwell, Bridget R.
Format: Article
Published: Springer Verlag 2011
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/23043/
https://doi.org/10.1007/s00383-011-2852-1
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spelling my.um.eprints.230432019-11-18T03:11:00Z http://eprints.um.edu.my/23043/ Gender differences in reduced substance P (SP) in children with slow-transit constipation Yik, Yee Ian Farmer, Pamela J. King, Sebastian K. Chow, C.W. Hutson, John M. Southwell, Bridget R. R Medicine Purpose: Adult slow-transit constipation (STC) occurs predominantly in females and is associated with low numbers of substance P (SP)-containing nerves in colonic circular muscle. Aim: To determine if reduced SP nerves is female predominant in paediatric STC. Methods: Children with STC were identified from records of more than 600 nuclear transit studies (NTS) and intestinal biopsies done for intractable chronic constipation between November 1998 and March 2009. Colonic seromuscular biopsies collected from hepatic and splenic flexures, and sigmoid colon were processed for immunohistochemistry. Nerve fibre density in circular muscle containing SP was measured qualitatively by a pathologist. Results: Eighty-eight children with chronic constipation had both NTS and intestinal biopsies. Seventy-eight children (52 M; age 2-15.5 years; mean 7.7 years) had STC diagnosed by NTS. SP was reduced in 10/26 girls, but only 11/52 boys. Conclusion: In this sample, STC was more common in boys than girls. However, in girls with STC, SP deficiency occurred in 40%, when compared with 20% of boys. During puberty, the percentage of girls with reduced SP decreased, whilst the percentage of boys increased. These results suggest that STC is heterogeneous and that there are some gender differences, the implication of which requires further investigation. © 2011 Springer-Verlag. Springer Verlag 2011 Article PeerReviewed Yik, Yee Ian and Farmer, Pamela J. and King, Sebastian K. and Chow, C.W. and Hutson, John M. and Southwell, Bridget R. (2011) Gender differences in reduced substance P (SP) in children with slow-transit constipation. Pediatric Surgery International, 27 (7). pp. 699-704. ISSN 0179-0358 https://doi.org/10.1007/s00383-011-2852-1 doi:10.1007/s00383-011-2852-1
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Yik, Yee Ian
Farmer, Pamela J.
King, Sebastian K.
Chow, C.W.
Hutson, John M.
Southwell, Bridget R.
Gender differences in reduced substance P (SP) in children with slow-transit constipation
description Purpose: Adult slow-transit constipation (STC) occurs predominantly in females and is associated with low numbers of substance P (SP)-containing nerves in colonic circular muscle. Aim: To determine if reduced SP nerves is female predominant in paediatric STC. Methods: Children with STC were identified from records of more than 600 nuclear transit studies (NTS) and intestinal biopsies done for intractable chronic constipation between November 1998 and March 2009. Colonic seromuscular biopsies collected from hepatic and splenic flexures, and sigmoid colon were processed for immunohistochemistry. Nerve fibre density in circular muscle containing SP was measured qualitatively by a pathologist. Results: Eighty-eight children with chronic constipation had both NTS and intestinal biopsies. Seventy-eight children (52 M; age 2-15.5 years; mean 7.7 years) had STC diagnosed by NTS. SP was reduced in 10/26 girls, but only 11/52 boys. Conclusion: In this sample, STC was more common in boys than girls. However, in girls with STC, SP deficiency occurred in 40%, when compared with 20% of boys. During puberty, the percentage of girls with reduced SP decreased, whilst the percentage of boys increased. These results suggest that STC is heterogeneous and that there are some gender differences, the implication of which requires further investigation. © 2011 Springer-Verlag.
format Article
author Yik, Yee Ian
Farmer, Pamela J.
King, Sebastian K.
Chow, C.W.
Hutson, John M.
Southwell, Bridget R.
author_facet Yik, Yee Ian
Farmer, Pamela J.
King, Sebastian K.
Chow, C.W.
Hutson, John M.
Southwell, Bridget R.
author_sort Yik, Yee Ian
title Gender differences in reduced substance P (SP) in children with slow-transit constipation
title_short Gender differences in reduced substance P (SP) in children with slow-transit constipation
title_full Gender differences in reduced substance P (SP) in children with slow-transit constipation
title_fullStr Gender differences in reduced substance P (SP) in children with slow-transit constipation
title_full_unstemmed Gender differences in reduced substance P (SP) in children with slow-transit constipation
title_sort gender differences in reduced substance p (sp) in children with slow-transit constipation
publisher Springer Verlag
publishDate 2011
url http://eprints.um.edu.my/23043/
https://doi.org/10.1007/s00383-011-2852-1
_version_ 1651867391339003904
score 13.211869

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