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Slow-transit constipation with concurrent upper gastrointestinal dysmotility and its response to transcutaneous electrical stimulation

Purpose: Transcutaneous electrical stimulation (TES) speeds up colonic transit in children with slow-transit constipation (STC). This study examined if concurrent upper gastrointestinal dysmotility (UGD) affected response to TES. Methods: Radio-nuclear transit studies (NTS) were performed before and...

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Main Authors: Yik, Yee Ian, Clarke, Melanie C. C., Catto-Smith, Anthony G., Robertson, Val J., Sutcliffe, Jonathan R., Chase, Janet W., Gibb, Susan, Cain, Timothy M., Cook, David J., Tudball, Coral F., Hutson, John M., Southwell, Bridget R.
Format: Article
Published: Springer Verlag 2011
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R Medicine
Online Access:http://eprints.um.edu.my/23042/
https://doi.org/10.1007/s00383-011-2872-x
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spelling my.um.eprints.230422019-11-18T03:04:26Z http://eprints.um.edu.my/23042/ Slow-transit constipation with concurrent upper gastrointestinal dysmotility and its response to transcutaneous electrical stimulation Yik, Yee Ian Clarke, Melanie C. C. Catto-Smith, Anthony G. Robertson, Val J. Sutcliffe, Jonathan R. Chase, Janet W. Gibb, Susan Cain, Timothy M. Cook, David J. Tudball, Coral F. Hutson, John M. Southwell, Bridget R. R Medicine Purpose: Transcutaneous electrical stimulation (TES) speeds up colonic transit in children with slow-transit constipation (STC). This study examined if concurrent upper gastrointestinal dysmotility (UGD) affected response to TES. Methods: Radio-nuclear transit studies (NTS) were performed before and after TES treatment of STC as part of a larger randomised controlled trial. UGD was defined as delayed gastric emptying and/or slow small bowel transit. Improvement was defined as increase of ≥1 Geometric Centre (median radiotracer position at each time [small bowel = 1, toilet = 6]). Results: Forty-six subjects completed the trial, 34 had NTS after stimulation (21 M, 8-17 years, mean 11.3 years; symptoms >9 years). Active stimulation increased transit in >50% versus only 25% with sham (p = 0.04). Seventeen children also had UGD. In children with STC and either normal upper GI motility (NUGM) and UGD, NTS improved slightly after 1 month (57 vs. 60%; p = 0.9) and more after 2 months (88 vs. 40%; p = 0.07). However, mean transit rate significantly increased with NUGM, but not UGD (5.0 ± 0.2: 3.6 ± 0.6, p < 0.01). Conclusion: Transcutaneous electrical stimulation was beneficial for STC, with response weakly associated with UGD. As measured by NTS, STC children with NUGM responded slightly more, but with significantly greater increased transit compared to those with UGD. Higher numbers are needed to determine if the difference is important. © 2011 Springer-Verlag. Springer Verlag 2011 Article PeerReviewed Yik, Yee Ian and Clarke, Melanie C. C. and Catto-Smith, Anthony G. and Robertson, Val J. and Sutcliffe, Jonathan R. and Chase, Janet W. and Gibb, Susan and Cain, Timothy M. and Cook, David J. and Tudball, Coral F. and Hutson, John M. and Southwell, Bridget R. (2011) Slow-transit constipation with concurrent upper gastrointestinal dysmotility and its response to transcutaneous electrical stimulation. Pediatric Surgery International, 27 (7). pp. 705-711. ISSN 0179-0358 https://doi.org/10.1007/s00383-011-2872-x doi:10.1007/s00383-011-2872-x
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Yik, Yee Ian
Clarke, Melanie C. C.
Catto-Smith, Anthony G.
Robertson, Val J.
Sutcliffe, Jonathan R.
Chase, Janet W.
Gibb, Susan
Cain, Timothy M.
Cook, David J.
Tudball, Coral F.
Hutson, John M.
Southwell, Bridget R.
Slow-transit constipation with concurrent upper gastrointestinal dysmotility and its response to transcutaneous electrical stimulation
description Purpose: Transcutaneous electrical stimulation (TES) speeds up colonic transit in children with slow-transit constipation (STC). This study examined if concurrent upper gastrointestinal dysmotility (UGD) affected response to TES. Methods: Radio-nuclear transit studies (NTS) were performed before and after TES treatment of STC as part of a larger randomised controlled trial. UGD was defined as delayed gastric emptying and/or slow small bowel transit. Improvement was defined as increase of ≥1 Geometric Centre (median radiotracer position at each time [small bowel = 1, toilet = 6]). Results: Forty-six subjects completed the trial, 34 had NTS after stimulation (21 M, 8-17 years, mean 11.3 years; symptoms >9 years). Active stimulation increased transit in >50% versus only 25% with sham (p = 0.04). Seventeen children also had UGD. In children with STC and either normal upper GI motility (NUGM) and UGD, NTS improved slightly after 1 month (57 vs. 60%; p = 0.9) and more after 2 months (88 vs. 40%; p = 0.07). However, mean transit rate significantly increased with NUGM, but not UGD (5.0 ± 0.2: 3.6 ± 0.6, p < 0.01). Conclusion: Transcutaneous electrical stimulation was beneficial for STC, with response weakly associated with UGD. As measured by NTS, STC children with NUGM responded slightly more, but with significantly greater increased transit compared to those with UGD. Higher numbers are needed to determine if the difference is important. © 2011 Springer-Verlag.
format Article
author Yik, Yee Ian
Clarke, Melanie C. C.
Catto-Smith, Anthony G.
Robertson, Val J.
Sutcliffe, Jonathan R.
Chase, Janet W.
Gibb, Susan
Cain, Timothy M.
Cook, David J.
Tudball, Coral F.
Hutson, John M.
Southwell, Bridget R.
author_facet Yik, Yee Ian
Clarke, Melanie C. C.
Catto-Smith, Anthony G.
Robertson, Val J.
Sutcliffe, Jonathan R.
Chase, Janet W.
Gibb, Susan
Cain, Timothy M.
Cook, David J.
Tudball, Coral F.
Hutson, John M.
Southwell, Bridget R.
author_sort Yik, Yee Ian
title Slow-transit constipation with concurrent upper gastrointestinal dysmotility and its response to transcutaneous electrical stimulation
title_short Slow-transit constipation with concurrent upper gastrointestinal dysmotility and its response to transcutaneous electrical stimulation
title_full Slow-transit constipation with concurrent upper gastrointestinal dysmotility and its response to transcutaneous electrical stimulation
title_fullStr Slow-transit constipation with concurrent upper gastrointestinal dysmotility and its response to transcutaneous electrical stimulation
title_full_unstemmed Slow-transit constipation with concurrent upper gastrointestinal dysmotility and its response to transcutaneous electrical stimulation
title_sort slow-transit constipation with concurrent upper gastrointestinal dysmotility and its response to transcutaneous electrical stimulation
publisher Springer Verlag
publishDate 2011
url http://eprints.um.edu.my/23042/
https://doi.org/10.1007/s00383-011-2872-x
_version_ 1651867391193251840
score 13.211869

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