Staff View: Alkaloids from Cryptocarya densiflora Blume (Lauraceae) and their cholinesterase inhibitory activity

Alkaloids from Cryptocarya densiflora Blume (Lauraceae) and their cholinesterase inhibitory activity

(−)-Desmethylsecoantofine N-oxide (1), a new seco-phenanthroindolizidine alkaloid along with prodensiflorins A and B (2-3), two new proaporphine alkaloids, were isolated from the leaves of Cryptocarya densiflora Blume. Their structures were established on the basis of 1D and 2D NMR techniques and LC...

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Main Authors:	Wan Othman, Wan Nurul Nazneem, Sivasothy, Yasodha, Liew, Sook Yee, Mohamad, Jamaludin, Nafiah, Mohd Azlan, Ahmad, Kartini, Litaudon, Marc, Awang, Khalijah
Format:	Article
Published:	Elsevier 2017
Subjects:	Q Science (General) QD Chemistry QH Natural history
Online Access:	http://eprints.um.edu.my/22831/ https://doi.org/10.1016/j.phytol.2017.07.002
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id	my.um.eprints.22831
record_format	eprints
spelling	my.um.eprints.228312019-10-24T04:00:29Z http://eprints.um.edu.my/22831/ Alkaloids from Cryptocarya densiflora Blume (Lauraceae) and their cholinesterase inhibitory activity Wan Othman, Wan Nurul Nazneem Sivasothy, Yasodha Liew, Sook Yee Mohamad, Jamaludin Nafiah, Mohd Azlan Ahmad, Kartini Litaudon, Marc Awang, Khalijah Q Science (General) QD Chemistry QH Natural history (−)-Desmethylsecoantofine N-oxide (1), a new seco-phenanthroindolizidine alkaloid along with prodensiflorins A and B (2-3), two new proaporphine alkaloids, were isolated from the leaves of Cryptocarya densiflora Blume. Their structures were established on the basis of 1D and 2D NMR techniques and LCMS-IT-TOF analysis. (+)-N-methyllaurotetanine (4), (+)-laurotetanine (5), (+)-nornantenine (6), crychine (7), (−)-isocaryachine (8), (+)-reticuline (9), (−)-desmethylsecoantofine (10), (+)-oridine (11), dicentrinone (12) and (−)-antofine (13) were also isolated with compounds 4, 7–9 and 12–13 being characterized for the first time in this plant. Compounds 1-3 were moderate to weak AChE and BChE inhibitors while compound 10 was a DPPH free radical scavenger. Elsevier 2017 Article PeerReviewed Wan Othman, Wan Nurul Nazneem and Sivasothy, Yasodha and Liew, Sook Yee and Mohamad, Jamaludin and Nafiah, Mohd Azlan and Ahmad, Kartini and Litaudon, Marc and Awang, Khalijah (2017) Alkaloids from Cryptocarya densiflora Blume (Lauraceae) and their cholinesterase inhibitory activity. Phytochemistry Letters, 21. pp. 230-236. ISSN 1874-3900 https://doi.org/10.1016/j.phytol.2017.07.002 doi:10.1016/j.phytol.2017.07.002
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	Q Science (General) QD Chemistry QH Natural history
spellingShingle	Q Science (General) QD Chemistry QH Natural history Wan Othman, Wan Nurul Nazneem Sivasothy, Yasodha Liew, Sook Yee Mohamad, Jamaludin Nafiah, Mohd Azlan Ahmad, Kartini Litaudon, Marc Awang, Khalijah Alkaloids from Cryptocarya densiflora Blume (Lauraceae) and their cholinesterase inhibitory activity
description	(−)-Desmethylsecoantofine N-oxide (1), a new seco-phenanthroindolizidine alkaloid along with prodensiflorins A and B (2-3), two new proaporphine alkaloids, were isolated from the leaves of Cryptocarya densiflora Blume. Their structures were established on the basis of 1D and 2D NMR techniques and LCMS-IT-TOF analysis. (+)-N-methyllaurotetanine (4), (+)-laurotetanine (5), (+)-nornantenine (6), crychine (7), (−)-isocaryachine (8), (+)-reticuline (9), (−)-desmethylsecoantofine (10), (+)-oridine (11), dicentrinone (12) and (−)-antofine (13) were also isolated with compounds 4, 7–9 and 12–13 being characterized for the first time in this plant. Compounds 1-3 were moderate to weak AChE and BChE inhibitors while compound 10 was a DPPH free radical scavenger.
format	Article
author	Wan Othman, Wan Nurul Nazneem Sivasothy, Yasodha Liew, Sook Yee Mohamad, Jamaludin Nafiah, Mohd Azlan Ahmad, Kartini Litaudon, Marc Awang, Khalijah
author_facet	Wan Othman, Wan Nurul Nazneem Sivasothy, Yasodha Liew, Sook Yee Mohamad, Jamaludin Nafiah, Mohd Azlan Ahmad, Kartini Litaudon, Marc Awang, Khalijah
author_sort	Wan Othman, Wan Nurul Nazneem
title	Alkaloids from Cryptocarya densiflora Blume (Lauraceae) and their cholinesterase inhibitory activity
title_short	Alkaloids from Cryptocarya densiflora Blume (Lauraceae) and their cholinesterase inhibitory activity
title_full	Alkaloids from Cryptocarya densiflora Blume (Lauraceae) and their cholinesterase inhibitory activity
title_fullStr	Alkaloids from Cryptocarya densiflora Blume (Lauraceae) and their cholinesterase inhibitory activity
title_full_unstemmed	Alkaloids from Cryptocarya densiflora Blume (Lauraceae) and their cholinesterase inhibitory activity
title_sort	alkaloids from cryptocarya densiflora blume (lauraceae) and their cholinesterase inhibitory activity
publisher	Elsevier
publishDate	2017
url	http://eprints.um.edu.my/22831/ https://doi.org/10.1016/j.phytol.2017.07.002
_version_	1648736224145309696
score	13.211869

Alkaloids from Cryptocarya densiflora Blume (Lauraceae) and their cholinesterase inhibitory activity

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