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Reduced mitochondrial DNA content in lymphocytes is associated with insulin resistance and inflammation in patients with impaired fasting glucose

Altered mitochondrial DNA (mtDNA) is the most common denominator to numerous metabolic diseases. The present study sought to investigate the correlation between mtDNA content in lymphocytes and associated clinical risk factors for impaired fasting glucose (IFG). We included 23 healthy control and 42...

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Main Authors: Abu Bakar, Mohamad Hafizi, Hairunisa, Nany, Huri, Hasniza Zaman
Format: Article
Published: Springer 2018
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R Medicine
Online Access:http://eprints.um.edu.my/22719/
https://doi.org/10.1007/s10238-018-0495-4
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spelling my.um.eprints.227192019-10-08T07:56:10Z http://eprints.um.edu.my/22719/ Reduced mitochondrial DNA content in lymphocytes is associated with insulin resistance and inflammation in patients with impaired fasting glucose Abu Bakar, Mohamad Hafizi Hairunisa, Nany Huri, Hasniza Zaman R Medicine Altered mitochondrial DNA (mtDNA) is the most common denominator to numerous metabolic diseases. The present study sought to investigate the correlation between mtDNA content in lymphocytes and associated clinical risk factors for impaired fasting glucose (IFG). We included 23 healthy control and 42 IFG participants in this cross-sectional study. The measurements of mtDNA content in lymphocytes and pro-inflammatory markers derived from both normal and diseased individuals were quantified. Spearman partial correlation and multivariate statistical analyses were employed to evaluate the association between mtDNA content and other metabolic covariates in IFG. Reduced mtDNA content was observed in the IFG group with microvascular complications than those without complications. The IFG patients with lowest median of mtDNA content had considerably elevated hyperglycemia, insulin resistance and inflammation. The adjusted partial correlation analysis showed that mtDNA content was positively correlated with HDL-cholesterol and IL-10 (P < 0.005 for all). Further, multiple linear regression analyses verified that reduced mtDNA content in lymphocytes was independently associated with HOMA-IR (β = 0.027, P = 0.003), HbA1c (β = 0.652, P = 0.002), HDL-cholesterol (β = − 1.056, P = 0.021), IL-6 (β = 0.423, P = 0.002), IL-10 (β = − 1.234, P = 0.043) and TNF-α (β = 0.542, P < 0.001) after adjustment for confounding factors. Our data show that reduced mtDNA content in lymphocytes was associated with insulin resistance and inflammation in individuals with IFG. Springer 2018 Article PeerReviewed Abu Bakar, Mohamad Hafizi and Hairunisa, Nany and Huri, Hasniza Zaman (2018) Reduced mitochondrial DNA content in lymphocytes is associated with insulin resistance and inflammation in patients with impaired fasting glucose. Clinical and Experimental Medicine, 18 (3). pp. 373-382. ISSN 1591-8890 https://doi.org/10.1007/s10238-018-0495-4 doi:10.1007/s10238-018-0495-4
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Abu Bakar, Mohamad Hafizi
Hairunisa, Nany
Huri, Hasniza Zaman
Reduced mitochondrial DNA content in lymphocytes is associated with insulin resistance and inflammation in patients with impaired fasting glucose
description Altered mitochondrial DNA (mtDNA) is the most common denominator to numerous metabolic diseases. The present study sought to investigate the correlation between mtDNA content in lymphocytes and associated clinical risk factors for impaired fasting glucose (IFG). We included 23 healthy control and 42 IFG participants in this cross-sectional study. The measurements of mtDNA content in lymphocytes and pro-inflammatory markers derived from both normal and diseased individuals were quantified. Spearman partial correlation and multivariate statistical analyses were employed to evaluate the association between mtDNA content and other metabolic covariates in IFG. Reduced mtDNA content was observed in the IFG group with microvascular complications than those without complications. The IFG patients with lowest median of mtDNA content had considerably elevated hyperglycemia, insulin resistance and inflammation. The adjusted partial correlation analysis showed that mtDNA content was positively correlated with HDL-cholesterol and IL-10 (P < 0.005 for all). Further, multiple linear regression analyses verified that reduced mtDNA content in lymphocytes was independently associated with HOMA-IR (β = 0.027, P = 0.003), HbA1c (β = 0.652, P = 0.002), HDL-cholesterol (β = − 1.056, P = 0.021), IL-6 (β = 0.423, P = 0.002), IL-10 (β = − 1.234, P = 0.043) and TNF-α (β = 0.542, P < 0.001) after adjustment for confounding factors. Our data show that reduced mtDNA content in lymphocytes was associated with insulin resistance and inflammation in individuals with IFG.
format Article
author Abu Bakar, Mohamad Hafizi
Hairunisa, Nany
Huri, Hasniza Zaman
author_facet Abu Bakar, Mohamad Hafizi
Hairunisa, Nany
Huri, Hasniza Zaman
author_sort Abu Bakar, Mohamad Hafizi
title Reduced mitochondrial DNA content in lymphocytes is associated with insulin resistance and inflammation in patients with impaired fasting glucose
title_short Reduced mitochondrial DNA content in lymphocytes is associated with insulin resistance and inflammation in patients with impaired fasting glucose
title_full Reduced mitochondrial DNA content in lymphocytes is associated with insulin resistance and inflammation in patients with impaired fasting glucose
title_fullStr Reduced mitochondrial DNA content in lymphocytes is associated with insulin resistance and inflammation in patients with impaired fasting glucose
title_full_unstemmed Reduced mitochondrial DNA content in lymphocytes is associated with insulin resistance and inflammation in patients with impaired fasting glucose
title_sort reduced mitochondrial dna content in lymphocytes is associated with insulin resistance and inflammation in patients with impaired fasting glucose
publisher Springer
publishDate 2018
url http://eprints.um.edu.my/22719/
https://doi.org/10.1007/s10238-018-0495-4
_version_ 1648736190974656512
score 13.211869

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