Staff View: Rheological behavior of biodegradable N -succinyl chitosan- g -poly (acrylic acid) hydrogels and their applications as drug carrier and in vitro theophylline release

Rheological behavior of biodegradable N -succinyl chitosan- g -poly (acrylic acid) hydrogels and their applications as drug carrier and in vitro theophylline release

Novel pH sensitive N-succinyl chitosan-g-poly (acrylic acid) hydrogels were synthesized through free radical mechanism. Rheometer was used to observe the mechanical strength of the hydrogels. In vitro degradation was conducted in SIF (pH 7.4). The effect of concentration of monomers, initiator, and...

Full description

Saved in:

Bibliographic Details
Main Authors:	Bashir, Shahid, Teo, Yin Yin, Ramesh, Subramaniam, Ramesh, Kasi, Mushtaq, Muhammad Waheed
Format:	Article
Published:	Elsevier 2018
Subjects:	Q Science (General) QC Physics QD Chemistry
Online Access:	http://eprints.um.edu.my/22342/ https://doi.org/10.1016/j.ijbiomac.2018.05.182
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my.um.eprints.22342
record_format	eprints
spelling	my.um.eprints.223422019-09-13T06:41:42Z http://eprints.um.edu.my/22342/ Rheological behavior of biodegradable N -succinyl chitosan- g -poly (acrylic acid) hydrogels and their applications as drug carrier and in vitro theophylline release Bashir, Shahid Teo, Yin Yin Ramesh, Subramaniam Ramesh, Kasi Mushtaq, Muhammad Waheed Q Science (General) QC Physics QD Chemistry Novel pH sensitive N-succinyl chitosan-g-poly (acrylic acid) hydrogels were synthesized through free radical mechanism. Rheometer was used to observe the mechanical strength of the hydrogels. In vitro degradation was conducted in SIF (pH 7.4). The effect of concentration of monomers, initiator, and crosslinking agent and pH and ionic strength of NaCl, CaCl2, and AlCl3 on swelling of the hydrogels was observed. The results showed that equilibrium swelling ratio was highly influenced by concentration of monomers, initiator, and crosslinking agent concentration, and pH and salt solutions of NaCl, CaCl2, and AlCl3. The swelling kinetics revealed that swelling followed non-Fickian anomalous transport. Furthermore, theophylline loading (DL %) and encapsulation efficiency (EE %) of the hydrogels was in the range of 15.5 ± 0.15–22.8 ± 0.06% and 62 ± 0.15–91 ± 0.26%, respectively. The release of theophylline in physiological mediums was strongly influenced by the pH. The theophylline release was in the range of 51 ± 0.20–92 ± 0.12% in SIF and 7.4 ± 0.02–14.9 ± 0.03% in SGF (pH 1.2), respectively. The release data fitted well to Korsmeyer-Peppas model. The chemical activity of the theophylline suggested that drug maintained its chemical activity after release in vitro. The results suggest that synthesized hydrogels are excellent drug carriers. Elsevier 2018 Article PeerReviewed Bashir, Shahid and Teo, Yin Yin and Ramesh, Subramaniam and Ramesh, Kasi and Mushtaq, Muhammad Waheed (2018) Rheological behavior of biodegradable N -succinyl chitosan- g -poly (acrylic acid) hydrogels and their applications as drug carrier and in vitro theophylline release. International Journal of Biological Macromolecules, 117. pp. 454-466. ISSN 0141-8130 https://doi.org/10.1016/j.ijbiomac.2018.05.182 doi:10.1016/j.ijbiomac.2018.05.182
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	Q Science (General) QC Physics QD Chemistry
spellingShingle	Q Science (General) QC Physics QD Chemistry Bashir, Shahid Teo, Yin Yin Ramesh, Subramaniam Ramesh, Kasi Mushtaq, Muhammad Waheed Rheological behavior of biodegradable N -succinyl chitosan- g -poly (acrylic acid) hydrogels and their applications as drug carrier and in vitro theophylline release
description	Novel pH sensitive N-succinyl chitosan-g-poly (acrylic acid) hydrogels were synthesized through free radical mechanism. Rheometer was used to observe the mechanical strength of the hydrogels. In vitro degradation was conducted in SIF (pH 7.4). The effect of concentration of monomers, initiator, and crosslinking agent and pH and ionic strength of NaCl, CaCl2, and AlCl3 on swelling of the hydrogels was observed. The results showed that equilibrium swelling ratio was highly influenced by concentration of monomers, initiator, and crosslinking agent concentration, and pH and salt solutions of NaCl, CaCl2, and AlCl3. The swelling kinetics revealed that swelling followed non-Fickian anomalous transport. Furthermore, theophylline loading (DL %) and encapsulation efficiency (EE %) of the hydrogels was in the range of 15.5 ± 0.15–22.8 ± 0.06% and 62 ± 0.15–91 ± 0.26%, respectively. The release of theophylline in physiological mediums was strongly influenced by the pH. The theophylline release was in the range of 51 ± 0.20–92 ± 0.12% in SIF and 7.4 ± 0.02–14.9 ± 0.03% in SGF (pH 1.2), respectively. The release data fitted well to Korsmeyer-Peppas model. The chemical activity of the theophylline suggested that drug maintained its chemical activity after release in vitro. The results suggest that synthesized hydrogels are excellent drug carriers.
format	Article
author	Bashir, Shahid Teo, Yin Yin Ramesh, Subramaniam Ramesh, Kasi Mushtaq, Muhammad Waheed
author_facet	Bashir, Shahid Teo, Yin Yin Ramesh, Subramaniam Ramesh, Kasi Mushtaq, Muhammad Waheed
author_sort	Bashir, Shahid
title	Rheological behavior of biodegradable N -succinyl chitosan- g -poly (acrylic acid) hydrogels and their applications as drug carrier and in vitro theophylline release
title_short	Rheological behavior of biodegradable N -succinyl chitosan- g -poly (acrylic acid) hydrogels and their applications as drug carrier and in vitro theophylline release
title_full	Rheological behavior of biodegradable N -succinyl chitosan- g -poly (acrylic acid) hydrogels and their applications as drug carrier and in vitro theophylline release
title_fullStr	Rheological behavior of biodegradable N -succinyl chitosan- g -poly (acrylic acid) hydrogels and their applications as drug carrier and in vitro theophylline release
title_full_unstemmed	Rheological behavior of biodegradable N -succinyl chitosan- g -poly (acrylic acid) hydrogels and their applications as drug carrier and in vitro theophylline release
title_sort	rheological behavior of biodegradable n -succinyl chitosan- g -poly (acrylic acid) hydrogels and their applications as drug carrier and in vitro theophylline release
publisher	Elsevier
publishDate	2018
url	http://eprints.um.edu.my/22342/ https://doi.org/10.1016/j.ijbiomac.2018.05.182
_version_	1646210214005833728
score	13.211869

Rheological behavior of biodegradable N -succinyl chitosan- g -poly (acrylic acid) hydrogels and their applications as drug carrier and in vitro theophylline release

Similar Items