Staff View: Doped silica fibre thermoluminescence measurements of radiation dose in the use of 223 Ra

Doped silica fibre thermoluminescence measurements of radiation dose in the use of 223 Ra

Using tailor-made sub-mm dimension doped-silica fibres, thermoluminescent dosimetric studies have been performed for α-emitting sources of 223RaCl2 (the basis of the Bayer Healthcare product Xofigo®). The use of 223RaCl2 in the palliative treatment of bone metastases resulting from late-stage castra...

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Main Authors:	Bradley, David Andrew, Sani, S.F. Abdul, Shafiqah, A.S. Siti, Collins, Sean M., Hugtenburg, Richard P., Rashid, Hairul Azhar Abdul, Zulkepely, Nurul Najua, Maah, Mohd Jamil
Format:	Article
Published:	Elsevier 2018
Subjects:	Q Science (General) QC Physics QD Chemistry
Online Access:	http://eprints.um.edu.my/22297/ https://doi.org/10.1016/j.apradiso.2017.04.019
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spelling	my.um.eprints.222972019-09-11T08:47:11Z http://eprints.um.edu.my/22297/ Doped silica fibre thermoluminescence measurements of radiation dose in the use of 223 Ra Bradley, David Andrew Sani, S.F. Abdul Shafiqah, A.S. Siti Collins, Sean M. Hugtenburg, Richard P. Rashid, Hairul Azhar Abdul Zulkepely, Nurul Najua Maah, Mohd Jamil Q Science (General) QC Physics QD Chemistry Using tailor-made sub-mm dimension doped-silica fibres, thermoluminescent dosimetric studies have been performed for α-emitting sources of 223RaCl2 (the basis of the Bayer Healthcare product Xofigo®). The use of 223RaCl2 in the palliative treatment of bone metastases resulting from late-stage castration-resistant prostate cancer focuses on its favourable uptake in metabolically active bone metastases. Such treatment benefits from the high linear energy transfer (LET) and associated short path length (<100 µm) of the α-particles emitted by 223Ra and its decay progeny. In seeking to provide for in vitro dosimetry of the α-particles originating from the 223Ra decay series, investigation has been made of the TL yield of various forms of Ge-doped SiO2 fibres, including photonic crystal fibre (PCF) collapsed, PCF uncollapsed, flat and single-mode fibres. Irradiations of the fibres were performed at the UK National Physical Laboratory (NPL). Notable features are the considerable sensitivity of the dosimeters and an effective atomic number Zeff approaching that of bone, the glass fibres offering the added advantage of being able to be placed directly into liquid. The outcome of present research is expected to inform development of doped fibre dosimeters of versatile utility, including for applications as detailed herein. Elsevier 2018 Article PeerReviewed Bradley, David Andrew and Sani, S.F. Abdul and Shafiqah, A.S. Siti and Collins, Sean M. and Hugtenburg, Richard P. and Rashid, Hairul Azhar Abdul and Zulkepely, Nurul Najua and Maah, Mohd Jamil (2018) Doped silica fibre thermoluminescence measurements of radiation dose in the use of 223 Ra. Applied Radiation and Isotopes, 138. pp. 65-72. ISSN 0969-8043 https://doi.org/10.1016/j.apradiso.2017.04.019 doi:10.1016/j.apradiso.2017.04.019
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	Q Science (General) QC Physics QD Chemistry
spellingShingle	Q Science (General) QC Physics QD Chemistry Bradley, David Andrew Sani, S.F. Abdul Shafiqah, A.S. Siti Collins, Sean M. Hugtenburg, Richard P. Rashid, Hairul Azhar Abdul Zulkepely, Nurul Najua Maah, Mohd Jamil Doped silica fibre thermoluminescence measurements of radiation dose in the use of 223 Ra
description	Using tailor-made sub-mm dimension doped-silica fibres, thermoluminescent dosimetric studies have been performed for α-emitting sources of 223RaCl2 (the basis of the Bayer Healthcare product Xofigo®). The use of 223RaCl2 in the palliative treatment of bone metastases resulting from late-stage castration-resistant prostate cancer focuses on its favourable uptake in metabolically active bone metastases. Such treatment benefits from the high linear energy transfer (LET) and associated short path length (<100 µm) of the α-particles emitted by 223Ra and its decay progeny. In seeking to provide for in vitro dosimetry of the α-particles originating from the 223Ra decay series, investigation has been made of the TL yield of various forms of Ge-doped SiO2 fibres, including photonic crystal fibre (PCF) collapsed, PCF uncollapsed, flat and single-mode fibres. Irradiations of the fibres were performed at the UK National Physical Laboratory (NPL). Notable features are the considerable sensitivity of the dosimeters and an effective atomic number Zeff approaching that of bone, the glass fibres offering the added advantage of being able to be placed directly into liquid. The outcome of present research is expected to inform development of doped fibre dosimeters of versatile utility, including for applications as detailed herein.
format	Article
author	Bradley, David Andrew Sani, S.F. Abdul Shafiqah, A.S. Siti Collins, Sean M. Hugtenburg, Richard P. Rashid, Hairul Azhar Abdul Zulkepely, Nurul Najua Maah, Mohd Jamil
author_facet	Bradley, David Andrew Sani, S.F. Abdul Shafiqah, A.S. Siti Collins, Sean M. Hugtenburg, Richard P. Rashid, Hairul Azhar Abdul Zulkepely, Nurul Najua Maah, Mohd Jamil
author_sort	Bradley, David Andrew
title	Doped silica fibre thermoluminescence measurements of radiation dose in the use of 223 Ra
title_short	Doped silica fibre thermoluminescence measurements of radiation dose in the use of 223 Ra
title_full	Doped silica fibre thermoluminescence measurements of radiation dose in the use of 223 Ra
title_fullStr	Doped silica fibre thermoluminescence measurements of radiation dose in the use of 223 Ra
title_full_unstemmed	Doped silica fibre thermoluminescence measurements of radiation dose in the use of 223 Ra
title_sort	doped silica fibre thermoluminescence measurements of radiation dose in the use of 223 ra
publisher	Elsevier
publishDate	2018
url	http://eprints.um.edu.my/22297/ https://doi.org/10.1016/j.apradiso.2017.04.019
_version_	1646210200827330560
score	13.211869

Doped silica fibre thermoluminescence measurements of radiation dose in the use of 223 Ra

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