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Quantitative analysis of intraventricular flow-energetics and vortex in ischaemic hearts

Objective This study investigated the intraventricular flow dynamics in ischaemic heart disease patients. Patients and methods Fourteen patients with normal ejection fraction and 16 patients with reduced ejection fraction were compared with 20 healthy individuals. Phase-contrast MRI was used to asse...

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Main Authors: Chan, Bee Ting, Yeoh, Hak Koon, Liew, Yih Miin, Dokos, Socrates, Al Abed, Amr, Chee, Kok Han, Abdul Aziz, Yang Faridah, Sridhar, Ganiga Srinivasaiah, Chinna, Karuthan, Lim, Einly
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Published: Lippincott, Williams & Wilkins 2018
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R Medicine
Online Access:http://eprints.um.edu.my/22285/
https://doi.org/10.1097/MCA.0000000000000596
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spelling my.um.eprints.222852019-09-11T03:18:14Z http://eprints.um.edu.my/22285/ Quantitative analysis of intraventricular flow-energetics and vortex in ischaemic hearts Chan, Bee Ting Yeoh, Hak Koon Liew, Yih Miin Dokos, Socrates Al Abed, Amr Chee, Kok Han Abdul Aziz, Yang Faridah Sridhar, Ganiga Srinivasaiah Chinna, Karuthan Lim, Einly R Medicine Objective This study investigated the intraventricular flow dynamics in ischaemic heart disease patients. Patients and methods Fourteen patients with normal ejection fraction and 16 patients with reduced ejection fraction were compared with 20 healthy individuals. Phase-contrast MRI was used to assess intraventricular flow variables and speckle-tracking echocardiography to assess myocardial strain and left ventricular (LV) dyssynchrony. Infarct size was acquired using delayed-enhancement MRI. Results The results obtained showed no significant differences in intraventricular flow variables between the healthy group and the patients with normal ejection fraction group, whereas considerable reductions in kinetic energy (KE) fluctuation index, E′ (P<0.001) and vortex KE (P=0.003) were found in the patients with reduced ejection fraction group. In multivariate analysis, only vortex KE and infarct size were significantly related to LV ejection fraction (P<0.001); furthermore, vortex KE was correlated negatively with energy dissipation, energy dissipation index (r=-0.44, P=0.021). Conclusion This study highlights that flow energetic indices have limited applicability as early predictors of LV progressive dysfunction, whereas vortex KE could be an alternative to LV performance. Lippincott, Williams & Wilkins 2018 Article PeerReviewed Chan, Bee Ting and Yeoh, Hak Koon and Liew, Yih Miin and Dokos, Socrates and Al Abed, Amr and Chee, Kok Han and Abdul Aziz, Yang Faridah and Sridhar, Ganiga Srinivasaiah and Chinna, Karuthan and Lim, Einly (2018) Quantitative analysis of intraventricular flow-energetics and vortex in ischaemic hearts. Coronary Artery Disease, 29 (4). pp. 316-324. ISSN 0954-6928 https://doi.org/10.1097/MCA.0000000000000596 doi:10.1097/MCA.0000000000000596
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Chan, Bee Ting
Yeoh, Hak Koon
Liew, Yih Miin
Dokos, Socrates
Al Abed, Amr
Chee, Kok Han
Abdul Aziz, Yang Faridah
Sridhar, Ganiga Srinivasaiah
Chinna, Karuthan
Lim, Einly
Quantitative analysis of intraventricular flow-energetics and vortex in ischaemic hearts
description Objective This study investigated the intraventricular flow dynamics in ischaemic heart disease patients. Patients and methods Fourteen patients with normal ejection fraction and 16 patients with reduced ejection fraction were compared with 20 healthy individuals. Phase-contrast MRI was used to assess intraventricular flow variables and speckle-tracking echocardiography to assess myocardial strain and left ventricular (LV) dyssynchrony. Infarct size was acquired using delayed-enhancement MRI. Results The results obtained showed no significant differences in intraventricular flow variables between the healthy group and the patients with normal ejection fraction group, whereas considerable reductions in kinetic energy (KE) fluctuation index, E′ (P<0.001) and vortex KE (P=0.003) were found in the patients with reduced ejection fraction group. In multivariate analysis, only vortex KE and infarct size were significantly related to LV ejection fraction (P<0.001); furthermore, vortex KE was correlated negatively with energy dissipation, energy dissipation index (r=-0.44, P=0.021). Conclusion This study highlights that flow energetic indices have limited applicability as early predictors of LV progressive dysfunction, whereas vortex KE could be an alternative to LV performance.
format Article
author Chan, Bee Ting
Yeoh, Hak Koon
Liew, Yih Miin
Dokos, Socrates
Al Abed, Amr
Chee, Kok Han
Abdul Aziz, Yang Faridah
Sridhar, Ganiga Srinivasaiah
Chinna, Karuthan
Lim, Einly
author_facet Chan, Bee Ting
Yeoh, Hak Koon
Liew, Yih Miin
Dokos, Socrates
Al Abed, Amr
Chee, Kok Han
Abdul Aziz, Yang Faridah
Sridhar, Ganiga Srinivasaiah
Chinna, Karuthan
Lim, Einly
author_sort Chan, Bee Ting
title Quantitative analysis of intraventricular flow-energetics and vortex in ischaemic hearts
title_short Quantitative analysis of intraventricular flow-energetics and vortex in ischaemic hearts
title_full Quantitative analysis of intraventricular flow-energetics and vortex in ischaemic hearts
title_fullStr Quantitative analysis of intraventricular flow-energetics and vortex in ischaemic hearts
title_full_unstemmed Quantitative analysis of intraventricular flow-energetics and vortex in ischaemic hearts
title_sort quantitative analysis of intraventricular flow-energetics and vortex in ischaemic hearts
publisher Lippincott, Williams & Wilkins
publishDate 2018
url http://eprints.um.edu.my/22285/
https://doi.org/10.1097/MCA.0000000000000596
_version_ 1646210197338718208
score 13.211869

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