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Antifungal and cytotoxic activities of selected medicinal plants from Malaysia

This study was conducted to investigate the antifungal potential and cytotoxicity of selected medicinal plants from Malaysia. The extracts from the stem of Cissus quadrangularis and the leaves of Asplenium nidus, Pereskia bleo, Persicaria odorata and Sauropus androgynus were assayed against six fung...

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Main Authors:	Chan, Yik Sin, Cheah, Yit Hong, Chong, Poh Zen, Khor, Hui Lai, Teh, Wen Siang, Khoo, Kong Soo, Ong, Hean Chooi, Sit, Nam Weng
Format:	Article
Published:	Faculty of Pharmacy, University of Karachi 2018
Subjects:	Q Science (General) QD Chemistry QH Natural history
Online Access:	http://eprints.um.edu.my/22271/ http://www.pjps.pk/wp-content/uploads/pdfs/31/1/Paper-17.pdf
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id	my.um.eprints.22271
record_format	eprints
spelling	my.um.eprints.222712019-09-06T03:48:33Z http://eprints.um.edu.my/22271/ Antifungal and cytotoxic activities of selected medicinal plants from Malaysia Chan, Yik Sin Cheah, Yit Hong Chong, Poh Zen Khor, Hui Lai Teh, Wen Siang Khoo, Kong Soo Ong, Hean Chooi Sit, Nam Weng Q Science (General) QD Chemistry QH Natural history This study was conducted to investigate the antifungal potential and cytotoxicity of selected medicinal plants from Malaysia. The extracts from the stem of Cissus quadrangularis and the leaves of Asplenium nidus, Pereskia bleo, Persicaria odorata and Sauropus androgynus were assayed against six fungi using p-iodonitrotetrazolium-based on colorimetric broth microdilution method. All the plant extracts were found to be fungicidal against at least one type of fungus. The strongest fungicidal activity (minimum fungicidal concentration=0.16 mg/mL) were exhibited by the hexane extract of C. quadrangularis, the hexane, chloroform, ethanol and methanol extracts of P. bleo, the hexane and ethyl acetate extracts of P. odorata, and the water extract of A. nidus. In terms of cytotoxicity on the African monkey kidney epithelial (Vero) cells, the chloroform extract of P. odorata produced the lowest 50% cytotoxic concentration (100.3 ± 4.2 μg/mL). In contrast, none of the water extracts from the studied plants caused significant toxicity on the cells. The water extract of A. nidus warrants further investigation since it showed the strongest fungicidal activity and the highest total activity (179.22 L/g) against Issatchenkia orientalis, and did not cause any toxicity to the Vero cells. Faculty of Pharmacy, University of Karachi 2018 Article PeerReviewed Chan, Yik Sin and Cheah, Yit Hong and Chong, Poh Zen and Khor, Hui Lai and Teh, Wen Siang and Khoo, Kong Soo and Ong, Hean Chooi and Sit, Nam Weng (2018) Antifungal and cytotoxic activities of selected medicinal plants from Malaysia. Pakistan Journal of Pharmaceutical Sciences, 31 (1). pp. 119-127. ISSN 1011-601X http://www.pjps.pk/wp-content/uploads/pdfs/31/1/Paper-17.pdf
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	Q Science (General) QD Chemistry QH Natural history
spellingShingle	Q Science (General) QD Chemistry QH Natural history Chan, Yik Sin Cheah, Yit Hong Chong, Poh Zen Khor, Hui Lai Teh, Wen Siang Khoo, Kong Soo Ong, Hean Chooi Sit, Nam Weng Antifungal and cytotoxic activities of selected medicinal plants from Malaysia
description	This study was conducted to investigate the antifungal potential and cytotoxicity of selected medicinal plants from Malaysia. The extracts from the stem of Cissus quadrangularis and the leaves of Asplenium nidus, Pereskia bleo, Persicaria odorata and Sauropus androgynus were assayed against six fungi using p-iodonitrotetrazolium-based on colorimetric broth microdilution method. All the plant extracts were found to be fungicidal against at least one type of fungus. The strongest fungicidal activity (minimum fungicidal concentration=0.16 mg/mL) were exhibited by the hexane extract of C. quadrangularis, the hexane, chloroform, ethanol and methanol extracts of P. bleo, the hexane and ethyl acetate extracts of P. odorata, and the water extract of A. nidus. In terms of cytotoxicity on the African monkey kidney epithelial (Vero) cells, the chloroform extract of P. odorata produced the lowest 50% cytotoxic concentration (100.3 ± 4.2 μg/mL). In contrast, none of the water extracts from the studied plants caused significant toxicity on the cells. The water extract of A. nidus warrants further investigation since it showed the strongest fungicidal activity and the highest total activity (179.22 L/g) against Issatchenkia orientalis, and did not cause any toxicity to the Vero cells.
format	Article
author	Chan, Yik Sin Cheah, Yit Hong Chong, Poh Zen Khor, Hui Lai Teh, Wen Siang Khoo, Kong Soo Ong, Hean Chooi Sit, Nam Weng
author_facet	Chan, Yik Sin Cheah, Yit Hong Chong, Poh Zen Khor, Hui Lai Teh, Wen Siang Khoo, Kong Soo Ong, Hean Chooi Sit, Nam Weng
author_sort	Chan, Yik Sin
title	Antifungal and cytotoxic activities of selected medicinal plants from Malaysia
title_short	Antifungal and cytotoxic activities of selected medicinal plants from Malaysia
title_full	Antifungal and cytotoxic activities of selected medicinal plants from Malaysia
title_fullStr	Antifungal and cytotoxic activities of selected medicinal plants from Malaysia
title_full_unstemmed	Antifungal and cytotoxic activities of selected medicinal plants from Malaysia
title_sort	antifungal and cytotoxic activities of selected medicinal plants from malaysia
publisher	Faculty of Pharmacy, University of Karachi
publishDate	2018
url	http://eprints.um.edu.my/22271/ http://www.pjps.pk/wp-content/uploads/pdfs/31/1/Paper-17.pdf
_version_	1646210193498832896
score	13.211869

Antifungal and cytotoxic activities of selected medicinal plants from Malaysia

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