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Reduced expression of AURKA in peripheral blood of breast cancer patients

AURKA, CENPW, and TIMP1 are reported to be genes involved in the regulation of the cell cycle and are highly associated with various cancers, including breast cancer (BC). These genes appear to be overexpressed in cancerous tissues, but unknown in peripheral blood. This study uses quantitative real-...

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Main Authors: Goh, Lucky Poh Wah, See, Edwin Un Hean, Chua, Kek Heng, Lee, Ping Chin
Format: Article
Published: Institute of Bioorganic Chemistry, Polish Academy of Sciences 2018
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/22012/
https://doi.org/10.5114/bta.2018.73564
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spelling my.um.eprints.220122019-08-21T06:50:42Z http://eprints.um.edu.my/22012/ Reduced expression of AURKA in peripheral blood of breast cancer patients Goh, Lucky Poh Wah See, Edwin Un Hean Chua, Kek Heng Lee, Ping Chin R Medicine AURKA, CENPW, and TIMP1 are reported to be genes involved in the regulation of the cell cycle and are highly associated with various cancers, including breast cancer (BC). These genes appear to be overexpressed in cancerous tissues, but unknown in peripheral blood. This study uses quantitative real-time PCR (qPCR) to assess the differential expression of AURKA, CENPW, and TIMP1 genes in the peripheral blood of BC patients and correlates expression levels with clinicopathological characteristics and etiological factors. We found that AURKA expression was significantly reduced in BC patients, as well as: 1) those without any family cancer history, 2) nonsmokers, and 3) those who engage in frequent consumption of red meat in the peripheral blood. However, all three genes in this study were not significantly correlated with clinicopathological characteristics of BC. Our study reveals that the expression of AURKA is significantly downregulated in the peripheral blood of BC patients. Institute of Bioorganic Chemistry, Polish Academy of Sciences 2018 Article PeerReviewed Goh, Lucky Poh Wah and See, Edwin Un Hean and Chua, Kek Heng and Lee, Ping Chin (2018) Reduced expression of AURKA in peripheral blood of breast cancer patients. BioTechnologia, 99 (1). pp. 83-90. ISSN 0860-7796 https://doi.org/10.5114/bta.2018.73564 doi:10.5114/bta.2018.73564
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Goh, Lucky Poh Wah
See, Edwin Un Hean
Chua, Kek Heng
Lee, Ping Chin
Reduced expression of AURKA in peripheral blood of breast cancer patients
description AURKA, CENPW, and TIMP1 are reported to be genes involved in the regulation of the cell cycle and are highly associated with various cancers, including breast cancer (BC). These genes appear to be overexpressed in cancerous tissues, but unknown in peripheral blood. This study uses quantitative real-time PCR (qPCR) to assess the differential expression of AURKA, CENPW, and TIMP1 genes in the peripheral blood of BC patients and correlates expression levels with clinicopathological characteristics and etiological factors. We found that AURKA expression was significantly reduced in BC patients, as well as: 1) those without any family cancer history, 2) nonsmokers, and 3) those who engage in frequent consumption of red meat in the peripheral blood. However, all three genes in this study were not significantly correlated with clinicopathological characteristics of BC. Our study reveals that the expression of AURKA is significantly downregulated in the peripheral blood of BC patients.
format Article
author Goh, Lucky Poh Wah
See, Edwin Un Hean
Chua, Kek Heng
Lee, Ping Chin
author_facet Goh, Lucky Poh Wah
See, Edwin Un Hean
Chua, Kek Heng
Lee, Ping Chin
author_sort Goh, Lucky Poh Wah
title Reduced expression of AURKA in peripheral blood of breast cancer patients
title_short Reduced expression of AURKA in peripheral blood of breast cancer patients
title_full Reduced expression of AURKA in peripheral blood of breast cancer patients
title_fullStr Reduced expression of AURKA in peripheral blood of breast cancer patients
title_full_unstemmed Reduced expression of AURKA in peripheral blood of breast cancer patients
title_sort reduced expression of aurka in peripheral blood of breast cancer patients
publisher Institute of Bioorganic Chemistry, Polish Academy of Sciences
publishDate 2018
url http://eprints.um.edu.my/22012/
https://doi.org/10.5114/bta.2018.73564
_version_ 1643691726940930048
score 13.211869

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