Staff View: Antibacterial effects of 18 medicinal plants used by the Khyang tribe in Bangladesh

Antibacterial effects of 18 medicinal plants used by the Khyang tribe in Bangladesh

Context: The resistance of bacteria to antibiotics is raising serious concern globally. Asian medicinal plants could improve the current treatment strategies for bacterial infections. The antibacterial properties of medicinal plants used by the Khyang tribe in Bangladesh have not been investigated....

Full description

Saved in:

Bibliographic Details
Main Authors:	Hossan, Md Shahadat, Jindal, Hassan Mahmood, Maisha, Sarah, Samudi, Chandramathi, Sekaran, Shamala Devi, Nissapatorn, Veeranoot, Kaharudin, Fatima, Su Yi, Lim, Khoo, Teng Jin, Rahmatullah, Mohammed, Wiart, Christophe
Format:	Article
Published:	Taylor & Francis 2018
Subjects:	R Medicine
Online Access:	http://eprints.um.edu.my/21866/ https://doi.org/10.1080/13880209.2018.1446030
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my.um.eprints.21866
record_format	eprints
spelling	my.um.eprints.218662019-08-07T07:10:38Z http://eprints.um.edu.my/21866/ Antibacterial effects of 18 medicinal plants used by the Khyang tribe in Bangladesh Hossan, Md Shahadat Jindal, Hassan Mahmood Maisha, Sarah Samudi, Chandramathi Sekaran, Shamala Devi Nissapatorn, Veeranoot Kaharudin, Fatima Su Yi, Lim Khoo, Teng Jin Rahmatullah, Mohammed Wiart, Christophe R Medicine Context: The resistance of bacteria to antibiotics is raising serious concern globally. Asian medicinal plants could improve the current treatment strategies for bacterial infections. The antibacterial properties of medicinal plants used by the Khyang tribe in Bangladesh have not been investigated. Objective: The present study examines the antibacterial properties of 18 medicinal plants used by the Khyang tribe in day-to-day practice against human pathogenic bacteria. Materials and methods: Leaves, bark, fruits, seeds, roots and rhizomes from collected plants were successively extracted with hexane, ethyl acetate and ethanol. The corresponding 54 extracts were tested against six human pathogenic bacteria by broth microdilution assay. The antibacterial mode of actions of phytoconstituents and their synergistic effect with vancomycin and cefotaxime towards MRSA was determined by time-killing assay and synergistic interaction assay, respectively. Results and discussion: Hexane extract of bark of Cinnamomum cassia (L.) J. Presl. (Lauraceae) inhibited the growth of MRSA, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae andAcinetobacter baumannii with MIC values below 100 µg/mL. From this plant, cinnamaldehyde evoked at 4 × MIC in 1 h an irreversible decrease of MRSA count Log10 (CFU/mL) from 6 to 0, and was synergistic with vancomycin for MRSA with fractional inhibitory concentration index of 0.3. Conclusions: Our study provides evidence that the medicinal plants in Bangladesh have high potential to improve the current treatment strategies for bacterial infection. Taylor & Francis 2018 Article PeerReviewed Hossan, Md Shahadat and Jindal, Hassan Mahmood and Maisha, Sarah and Samudi, Chandramathi and Sekaran, Shamala Devi and Nissapatorn, Veeranoot and Kaharudin, Fatima and Su Yi, Lim and Khoo, Teng Jin and Rahmatullah, Mohammed and Wiart, Christophe (2018) Antibacterial effects of 18 medicinal plants used by the Khyang tribe in Bangladesh. Pharmaceutical Biology, 56 (1). pp. 201-208. ISSN 1388-0209 https://doi.org/10.1080/13880209.2018.1446030 doi:10.1080/13880209.2018.1446030
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine
spellingShingle	R Medicine Hossan, Md Shahadat Jindal, Hassan Mahmood Maisha, Sarah Samudi, Chandramathi Sekaran, Shamala Devi Nissapatorn, Veeranoot Kaharudin, Fatima Su Yi, Lim Khoo, Teng Jin Rahmatullah, Mohammed Wiart, Christophe Antibacterial effects of 18 medicinal plants used by the Khyang tribe in Bangladesh
description	Context: The resistance of bacteria to antibiotics is raising serious concern globally. Asian medicinal plants could improve the current treatment strategies for bacterial infections. The antibacterial properties of medicinal plants used by the Khyang tribe in Bangladesh have not been investigated. Objective: The present study examines the antibacterial properties of 18 medicinal plants used by the Khyang tribe in day-to-day practice against human pathogenic bacteria. Materials and methods: Leaves, bark, fruits, seeds, roots and rhizomes from collected plants were successively extracted with hexane, ethyl acetate and ethanol. The corresponding 54 extracts were tested against six human pathogenic bacteria by broth microdilution assay. The antibacterial mode of actions of phytoconstituents and their synergistic effect with vancomycin and cefotaxime towards MRSA was determined by time-killing assay and synergistic interaction assay, respectively. Results and discussion: Hexane extract of bark of Cinnamomum cassia (L.) J. Presl. (Lauraceae) inhibited the growth of MRSA, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae andAcinetobacter baumannii with MIC values below 100 µg/mL. From this plant, cinnamaldehyde evoked at 4 × MIC in 1 h an irreversible decrease of MRSA count Log10 (CFU/mL) from 6 to 0, and was synergistic with vancomycin for MRSA with fractional inhibitory concentration index of 0.3. Conclusions: Our study provides evidence that the medicinal plants in Bangladesh have high potential to improve the current treatment strategies for bacterial infection.
format	Article
author	Hossan, Md Shahadat Jindal, Hassan Mahmood Maisha, Sarah Samudi, Chandramathi Sekaran, Shamala Devi Nissapatorn, Veeranoot Kaharudin, Fatima Su Yi, Lim Khoo, Teng Jin Rahmatullah, Mohammed Wiart, Christophe
author_facet	Hossan, Md Shahadat Jindal, Hassan Mahmood Maisha, Sarah Samudi, Chandramathi Sekaran, Shamala Devi Nissapatorn, Veeranoot Kaharudin, Fatima Su Yi, Lim Khoo, Teng Jin Rahmatullah, Mohammed Wiart, Christophe
author_sort	Hossan, Md Shahadat
title	Antibacterial effects of 18 medicinal plants used by the Khyang tribe in Bangladesh
title_short	Antibacterial effects of 18 medicinal plants used by the Khyang tribe in Bangladesh
title_full	Antibacterial effects of 18 medicinal plants used by the Khyang tribe in Bangladesh
title_fullStr	Antibacterial effects of 18 medicinal plants used by the Khyang tribe in Bangladesh
title_full_unstemmed	Antibacterial effects of 18 medicinal plants used by the Khyang tribe in Bangladesh
title_sort	antibacterial effects of 18 medicinal plants used by the khyang tribe in bangladesh
publisher	Taylor & Francis
publishDate	2018
url	http://eprints.um.edu.my/21866/ https://doi.org/10.1080/13880209.2018.1446030
_version_	1643691681991622656
score	13.211869

Antibacterial effects of 18 medicinal plants used by the Khyang tribe in Bangladesh

Similar Items