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STK15 Phe31Ile and Val57Ile Polymorphisms Increase the Risk of Gastrointestinal Cancer

STK15 is a serine/threonine kinase that regulates chromosomal segregation during mitosis. Single nucleotide polymorphisms (SNPs) in this gene, Phe31Ile (rs2273535) and Val57Ile (rs1047972), are inconsistently associated with gastrointestinal cancer (GIC) across different populations. However, this a...

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Main Authors: Lai, Tianxin, Chong, Eric Tzyy Jiann, Chuah, Jitt Aun, Chua, Kek Heng, Lee, Ping Chin
Format: Article
Published: Penerbit Universiti Kebangsaan Malaysia 2018
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R Medicine
Online Access:http://eprints.um.edu.my/21554/
https://doi.org/10.17576/jsm-2018-4701-17
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spelling my.um.eprints.215542019-06-27T02:43:41Z http://eprints.um.edu.my/21554/ STK15 Phe31Ile and Val57Ile Polymorphisms Increase the Risk of Gastrointestinal Cancer Lai, Tianxin Chong, Eric Tzyy Jiann Chuah, Jitt Aun Chua, Kek Heng Lee, Ping Chin R Medicine STK15 is a serine/threonine kinase that regulates chromosomal segregation during mitosis. Single nucleotide polymorphisms (SNPs) in this gene, Phe31Ile (rs2273535) and Val57Ile (rs1047972), are inconsistently associated with gastrointestinal cancer (GIC) across different populations. However, this association is unclear in Malaysian population. Therefore, this study investigated the association of STK15 Phe31Ile and Val57Ile polymorphisms to GIC risk in Malaysia. Genomic DNA was extracted from 185 GIC patients and 1110 healthy controls and was subjected to polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. SNPs were further confirmed using sequencing. We found that the 31Phe allele and 31Phe/Phe genotype in the Phe31Ile SNP significantly increased GIC risk in Malaysian population, particularly in gastric cancer (p<0.017). The combined analysis for both SNPs also increased the risk of GIC in this study. Etiological factors such as age, gender and ethnicity were not associated with GIC in the population. This is the first study to report the association of STK15 Phe31Ile and Val57Ile SNPs with an increased risk of GIC in Malaysians; the 31Phe allele is exclusively associated with the risk of gastric cancer. In addition, GIC incidences among Malaysians have significantly shifted to a younger age (<50 years). Penerbit Universiti Kebangsaan Malaysia 2018 Article PeerReviewed Lai, Tianxin and Chong, Eric Tzyy Jiann and Chuah, Jitt Aun and Chua, Kek Heng and Lee, Ping Chin (2018) STK15 Phe31Ile and Val57Ile Polymorphisms Increase the Risk of Gastrointestinal Cancer. Sains Malaysiana, 47 (1). pp. 141-148. ISSN 0126-6039 https://doi.org/10.17576/jsm-2018-4701-17 doi:10.17576/jsm-2018-4701-17
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Lai, Tianxin
Chong, Eric Tzyy Jiann
Chuah, Jitt Aun
Chua, Kek Heng
Lee, Ping Chin
STK15 Phe31Ile and Val57Ile Polymorphisms Increase the Risk of Gastrointestinal Cancer
description STK15 is a serine/threonine kinase that regulates chromosomal segregation during mitosis. Single nucleotide polymorphisms (SNPs) in this gene, Phe31Ile (rs2273535) and Val57Ile (rs1047972), are inconsistently associated with gastrointestinal cancer (GIC) across different populations. However, this association is unclear in Malaysian population. Therefore, this study investigated the association of STK15 Phe31Ile and Val57Ile polymorphisms to GIC risk in Malaysia. Genomic DNA was extracted from 185 GIC patients and 1110 healthy controls and was subjected to polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. SNPs were further confirmed using sequencing. We found that the 31Phe allele and 31Phe/Phe genotype in the Phe31Ile SNP significantly increased GIC risk in Malaysian population, particularly in gastric cancer (p<0.017). The combined analysis for both SNPs also increased the risk of GIC in this study. Etiological factors such as age, gender and ethnicity were not associated with GIC in the population. This is the first study to report the association of STK15 Phe31Ile and Val57Ile SNPs with an increased risk of GIC in Malaysians; the 31Phe allele is exclusively associated with the risk of gastric cancer. In addition, GIC incidences among Malaysians have significantly shifted to a younger age (<50 years).
format Article
author Lai, Tianxin
Chong, Eric Tzyy Jiann
Chuah, Jitt Aun
Chua, Kek Heng
Lee, Ping Chin
author_facet Lai, Tianxin
Chong, Eric Tzyy Jiann
Chuah, Jitt Aun
Chua, Kek Heng
Lee, Ping Chin
author_sort Lai, Tianxin
title STK15 Phe31Ile and Val57Ile Polymorphisms Increase the Risk of Gastrointestinal Cancer
title_short STK15 Phe31Ile and Val57Ile Polymorphisms Increase the Risk of Gastrointestinal Cancer
title_full STK15 Phe31Ile and Val57Ile Polymorphisms Increase the Risk of Gastrointestinal Cancer
title_fullStr STK15 Phe31Ile and Val57Ile Polymorphisms Increase the Risk of Gastrointestinal Cancer
title_full_unstemmed STK15 Phe31Ile and Val57Ile Polymorphisms Increase the Risk of Gastrointestinal Cancer
title_sort stk15 phe31ile and val57ile polymorphisms increase the risk of gastrointestinal cancer
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2018
url http://eprints.um.edu.my/21554/
https://doi.org/10.17576/jsm-2018-4701-17
_version_ 1643691592365637632
score 13.211869

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