Cover Image

Fabrication and characterization of graphene hydrogel via hydrothermal approach as a scaffold for preliminary study of cell growth

BACKGROUND: Three-dimensional assembly of graphene hydrogel is rapidly attracting the interest of researchers because of its wide range of applications in energy storage, electronics, electrochemistry, and waste water treatment. Information on the use of graphene hydrogel for biological purposes...

Full description

Saved in:
Bibliographic Details
Main Authors: Lim, H., Huang, N., Lim, S., Harrison, I., Chia, C.
Format: Article
Language:English
Published: Dove Medical Press 2011
Subjects:
Q Science (General)
Online Access:http://eprints.um.edu.my/2145/1/3.pdf
http://eprints.um.edu.my/2145/
http://www.ncbi.nlm.nih.gov/pubmed/21931479
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.um.eprints.2145
record_format eprints
spelling my.um.eprints.21452019-12-03T17:51:56Z http://eprints.um.edu.my/2145/ Fabrication and characterization of graphene hydrogel via hydrothermal approach as a scaffold for preliminary study of cell growth Lim, H. Huang, N. Lim, S. Harrison, I. Chia, C. Q Science (General) BACKGROUND: Three-dimensional assembly of graphene hydrogel is rapidly attracting the interest of researchers because of its wide range of applications in energy storage, electronics, electrochemistry, and waste water treatment. Information on the use of graphene hydrogel for biological purposes is lacking, so we conducted a preliminary study to determine the suitability of graphene hydrogel as a substrate for cell growth, which could potentially be used as building blocks for biomolecules and tissue engineering applications. METHODS: A three-dimensional structure of graphene hydrogel was prepared via a simple hydrothermal method using two-dimensional large-area graphene oxide nanosheets as a precursor. RESULTS: The concentration and lateral size of the graphene oxide nanosheets influenced the structure of the hydrogel. With larger-area graphene oxide nanosheets, the graphene hydrogel could be formed at a lower concentration. X-ray diffraction patterns revealed that the oxide functional groups on the graphene oxide nanosheets were reduced after hydrothermal treatment. The three-dimensional graphene hydrogel matrix was used as a scaffold for proliferation of a MG63 cell line. CONCLUSION: Guided filopodia protrusions of MG63 on the hydrogel were observed on the third day of cell culture, demonstrating compatibility of the graphene hydrogel structure for bioapplications. Dove Medical Press 2011 Article PeerReviewed application/pdf en http://eprints.um.edu.my/2145/1/3.pdf Lim, H. and Huang, N. and Lim, S. and Harrison, I. and Chia, C. (2011) Fabrication and characterization of graphene hydrogel via hydrothermal approach as a scaffold for preliminary study of cell growth. International Journal of Nanomedicine, 6. pp. 1817-1823. ISSN 1176-9114 http://www.ncbi.nlm.nih.gov/pubmed/21931479
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic Q Science (General)
spellingShingle Q Science (General)
Lim, H.
Huang, N.
Lim, S.
Harrison, I.
Chia, C.
Fabrication and characterization of graphene hydrogel via hydrothermal approach as a scaffold for preliminary study of cell growth
description BACKGROUND: Three-dimensional assembly of graphene hydrogel is rapidly attracting the interest of researchers because of its wide range of applications in energy storage, electronics, electrochemistry, and waste water treatment. Information on the use of graphene hydrogel for biological purposes is lacking, so we conducted a preliminary study to determine the suitability of graphene hydrogel as a substrate for cell growth, which could potentially be used as building blocks for biomolecules and tissue engineering applications. METHODS: A three-dimensional structure of graphene hydrogel was prepared via a simple hydrothermal method using two-dimensional large-area graphene oxide nanosheets as a precursor. RESULTS: The concentration and lateral size of the graphene oxide nanosheets influenced the structure of the hydrogel. With larger-area graphene oxide nanosheets, the graphene hydrogel could be formed at a lower concentration. X-ray diffraction patterns revealed that the oxide functional groups on the graphene oxide nanosheets were reduced after hydrothermal treatment. The three-dimensional graphene hydrogel matrix was used as a scaffold for proliferation of a MG63 cell line. CONCLUSION: Guided filopodia protrusions of MG63 on the hydrogel were observed on the third day of cell culture, demonstrating compatibility of the graphene hydrogel structure for bioapplications.
format Article
author Lim, H.
Huang, N.
Lim, S.
Harrison, I.
Chia, C.
author_facet Lim, H.
Huang, N.
Lim, S.
Harrison, I.
Chia, C.
author_sort Lim, H.
title Fabrication and characterization of graphene hydrogel via hydrothermal approach as a scaffold for preliminary study of cell growth
title_short Fabrication and characterization of graphene hydrogel via hydrothermal approach as a scaffold for preliminary study of cell growth
title_full Fabrication and characterization of graphene hydrogel via hydrothermal approach as a scaffold for preliminary study of cell growth
title_fullStr Fabrication and characterization of graphene hydrogel via hydrothermal approach as a scaffold for preliminary study of cell growth
title_full_unstemmed Fabrication and characterization of graphene hydrogel via hydrothermal approach as a scaffold for preliminary study of cell growth
title_sort fabrication and characterization of graphene hydrogel via hydrothermal approach as a scaffold for preliminary study of cell growth
publisher Dove Medical Press
publishDate 2011
url http://eprints.um.edu.my/2145/1/3.pdf
http://eprints.um.edu.my/2145/
http://www.ncbi.nlm.nih.gov/pubmed/21931479
_version_ 1654960581957910528
score 13.211869

Similar Items