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Survival and Associated Risk Factors for Mortality Among Infants with Critical Congenital Heart Disease in a Developing Country

Critical congenital heart disease (CCHD) is associated with significant morbidity and mortality. However, data on survival of CCHD and the risk factors associated with its mortality are limited. This study examined CCHD survival and the risk factors for CCHD mortality. Using a retrospective cohort s...

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Main Authors: Mat Bah, Mohd Nizam, Sapian, Mohd Hanafi, Jamil, Mohammad Tamim, Alias, Amelia, Zahari, Norazah
Format: Article
Published: Springer Verlag 2018
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/21321/
https://doi.org/10.1007/s00246-018-1908-6
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spelling my.um.eprints.213212019-05-27T04:47:02Z http://eprints.um.edu.my/21321/ Survival and Associated Risk Factors for Mortality Among Infants with Critical Congenital Heart Disease in a Developing Country Mat Bah, Mohd Nizam Sapian, Mohd Hanafi Jamil, Mohammad Tamim Alias, Amelia Zahari, Norazah R Medicine Critical congenital heart disease (CCHD) is associated with significant morbidity and mortality. However, data on survival of CCHD and the risk factors associated with its mortality are limited. This study examined CCHD survival and the risk factors for CCHD mortality. Using a retrospective cohort study of infants born with CCHD from 2006 to 2015, survival over 10 years was estimated using Kaplan–Meier analysis, and the risk factors for mortality were analyzed using multivariate Cox proportional hazards regression. A total of 491 CCHD cases were included in the study, with an overall mortality rate of 34.8% (95% confidence interval [CI] 30.6–39.2). The intervention/surgical mortality rate was 9.8% ≤ 30 days and 11.5% > 30 days after surgery, and 17% died before surgery or intervention. The median age at death was 2.7 months [first quartile: 1 month, third quartile: 7.3 months]. The CCHD survival rate was 90.4% (95% CI 89–91.8%) at 1 month, 69.3% (95% CI 67.2–71.4%) at 1 year, 63.4% (95% CI 61.1–65.7%) at 5 years, and 61.4% (95% CI 58.9–63.9%) at 10 years. Weight of < 2 kg at diagnosis, associated syndromes, poor pre-operative condition, and non-duct-dependent CCHD were independent risk factors for poor survival, with hazard ratios of 2.61, 2.10, 2.22, and 1.70, respectively. CCHD is associated with a high mortality rate. Low weight, poor pre-operative condition, associated syndromes, and non-duct-dependent CCHD are significant risk factors affecting the survival of infants with CCHD. Springer Verlag 2018 Article PeerReviewed Mat Bah, Mohd Nizam and Sapian, Mohd Hanafi and Jamil, Mohammad Tamim and Alias, Amelia and Zahari, Norazah (2018) Survival and Associated Risk Factors for Mortality Among Infants with Critical Congenital Heart Disease in a Developing Country. Pediatric Cardiology, 39 (7). pp. 1389-1396. ISSN 0172-0643 https://doi.org/10.1007/s00246-018-1908-6 doi:10.1007/s00246-018-1908-6
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Mat Bah, Mohd Nizam
Sapian, Mohd Hanafi
Jamil, Mohammad Tamim
Alias, Amelia
Zahari, Norazah
Survival and Associated Risk Factors for Mortality Among Infants with Critical Congenital Heart Disease in a Developing Country
description Critical congenital heart disease (CCHD) is associated with significant morbidity and mortality. However, data on survival of CCHD and the risk factors associated with its mortality are limited. This study examined CCHD survival and the risk factors for CCHD mortality. Using a retrospective cohort study of infants born with CCHD from 2006 to 2015, survival over 10 years was estimated using Kaplan–Meier analysis, and the risk factors for mortality were analyzed using multivariate Cox proportional hazards regression. A total of 491 CCHD cases were included in the study, with an overall mortality rate of 34.8% (95% confidence interval [CI] 30.6–39.2). The intervention/surgical mortality rate was 9.8% ≤ 30 days and 11.5% > 30 days after surgery, and 17% died before surgery or intervention. The median age at death was 2.7 months [first quartile: 1 month, third quartile: 7.3 months]. The CCHD survival rate was 90.4% (95% CI 89–91.8%) at 1 month, 69.3% (95% CI 67.2–71.4%) at 1 year, 63.4% (95% CI 61.1–65.7%) at 5 years, and 61.4% (95% CI 58.9–63.9%) at 10 years. Weight of < 2 kg at diagnosis, associated syndromes, poor pre-operative condition, and non-duct-dependent CCHD were independent risk factors for poor survival, with hazard ratios of 2.61, 2.10, 2.22, and 1.70, respectively. CCHD is associated with a high mortality rate. Low weight, poor pre-operative condition, associated syndromes, and non-duct-dependent CCHD are significant risk factors affecting the survival of infants with CCHD.
format Article
author Mat Bah, Mohd Nizam
Sapian, Mohd Hanafi
Jamil, Mohammad Tamim
Alias, Amelia
Zahari, Norazah
author_facet Mat Bah, Mohd Nizam
Sapian, Mohd Hanafi
Jamil, Mohammad Tamim
Alias, Amelia
Zahari, Norazah
author_sort Mat Bah, Mohd Nizam
title Survival and Associated Risk Factors for Mortality Among Infants with Critical Congenital Heart Disease in a Developing Country
title_short Survival and Associated Risk Factors for Mortality Among Infants with Critical Congenital Heart Disease in a Developing Country
title_full Survival and Associated Risk Factors for Mortality Among Infants with Critical Congenital Heart Disease in a Developing Country
title_fullStr Survival and Associated Risk Factors for Mortality Among Infants with Critical Congenital Heart Disease in a Developing Country
title_full_unstemmed Survival and Associated Risk Factors for Mortality Among Infants with Critical Congenital Heart Disease in a Developing Country
title_sort survival and associated risk factors for mortality among infants with critical congenital heart disease in a developing country
publisher Springer Verlag
publishDate 2018
url http://eprints.um.edu.my/21321/
https://doi.org/10.1007/s00246-018-1908-6
_version_ 1643691530543693824
score 13.211869

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