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The birth prevalence, severity, and temporal trends of congenital heart disease in the middle-income country: A population-based study

Objectives: There is limited data on congenital heart disease (CHD) from the lower- and middle-income country. We aim to study the epidemiology of CHD with the specific objective to estimate the birth prevalence, severity, and its trend over time. Design: A population-based study with data retrieved...

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Main Authors: Mat Bah, Mohd Nizam, Sapian, Mohd Hanafi, Jamil, Mohammad Tamim, Abdullah, Nisah, Alias, Emieliyuza Yusnita, Zahari, Norazah
Format: Article
Published: Wiley 2018
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R Medicine
Online Access:http://eprints.um.edu.my/21320/
https://doi.org/10.1111/chd.12672
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spelling my.um.eprints.213202019-05-27T04:44:42Z http://eprints.um.edu.my/21320/ The birth prevalence, severity, and temporal trends of congenital heart disease in the middle-income country: A population-based study Mat Bah, Mohd Nizam Sapian, Mohd Hanafi Jamil, Mohammad Tamim Abdullah, Nisah Alias, Emieliyuza Yusnita Zahari, Norazah R Medicine Objectives: There is limited data on congenital heart disease (CHD) from the lower- and middle-income country. We aim to study the epidemiology of CHD with the specific objective to estimate the birth prevalence, severity, and its trend over time. Design: A population-based study with data retrieved from the Pediatric Cardiology Clinical Information System, a clinical registry of acquired and congenital heart disease for children. Setting: State of Johor, Malaysia. Patients: All children (0-12 years of age) born in the state of Johor between January 2006 and December 2015. Intervention: None. Outcome measure: The birth prevalence, severity, and temporal trend over time. Results: There were 531,904 live births during the study period with 3557 new cases of CHD detected. Therefore, the birth prevalence of CHD was 6.7 per 1000 live births (LB) (95% confidence interval [CI]: 6.5-6.9). Of these, 38% were severe, 15% moderate, and 47% mild lesions. Hence, the birth prevalence of mild, moderate, and severe CHD was 3.2 (95% CI: 3.0-3.3), 0.9 (95% CI: 0.9- 1.1), and 2.6 (95% CI: 2.4-2.7) per 1000 LB, respectively. There was a significant increase in the birth prevalence of CHD, from 5.1/1000 LB in 2006 to 7.8/1000 LB in 2015 (P <.0001) due to increase in detection of both mild (1.9/1000 LB in 2006 to 3.9/1000 LB in 2015, P <.001) and severe CHD (1.8/1000 LB in 2005 to 2.9/1000 LB in 2015, P <.001). Conclusions: The birth prevalence of CHD was 6.7 per 1000 live births, and two in five were severe and significantly associated with syndrome and extracardiac defect. There was a significant increase in the detection of severe lesions in recent years leading to more burden to resources that are already limited in the middle-income country. Therefore, strategic and comprehensive pediatric and congenital heart surgery program is required. Wiley 2018 Article PeerReviewed Mat Bah, Mohd Nizam and Sapian, Mohd Hanafi and Jamil, Mohammad Tamim and Abdullah, Nisah and Alias, Emieliyuza Yusnita and Zahari, Norazah (2018) The birth prevalence, severity, and temporal trends of congenital heart disease in the middle-income country: A population-based study. Congenital Heart Disease, 13 (6). pp. 1012-1027. ISSN 1747-079X https://doi.org/10.1111/chd.12672 doi:10.1111/chd.12672
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Mat Bah, Mohd Nizam
Sapian, Mohd Hanafi
Jamil, Mohammad Tamim
Abdullah, Nisah
Alias, Emieliyuza Yusnita
Zahari, Norazah
The birth prevalence, severity, and temporal trends of congenital heart disease in the middle-income country: A population-based study
description Objectives: There is limited data on congenital heart disease (CHD) from the lower- and middle-income country. We aim to study the epidemiology of CHD with the specific objective to estimate the birth prevalence, severity, and its trend over time. Design: A population-based study with data retrieved from the Pediatric Cardiology Clinical Information System, a clinical registry of acquired and congenital heart disease for children. Setting: State of Johor, Malaysia. Patients: All children (0-12 years of age) born in the state of Johor between January 2006 and December 2015. Intervention: None. Outcome measure: The birth prevalence, severity, and temporal trend over time. Results: There were 531,904 live births during the study period with 3557 new cases of CHD detected. Therefore, the birth prevalence of CHD was 6.7 per 1000 live births (LB) (95% confidence interval [CI]: 6.5-6.9). Of these, 38% were severe, 15% moderate, and 47% mild lesions. Hence, the birth prevalence of mild, moderate, and severe CHD was 3.2 (95% CI: 3.0-3.3), 0.9 (95% CI: 0.9- 1.1), and 2.6 (95% CI: 2.4-2.7) per 1000 LB, respectively. There was a significant increase in the birth prevalence of CHD, from 5.1/1000 LB in 2006 to 7.8/1000 LB in 2015 (P <.0001) due to increase in detection of both mild (1.9/1000 LB in 2006 to 3.9/1000 LB in 2015, P <.001) and severe CHD (1.8/1000 LB in 2005 to 2.9/1000 LB in 2015, P <.001). Conclusions: The birth prevalence of CHD was 6.7 per 1000 live births, and two in five were severe and significantly associated with syndrome and extracardiac defect. There was a significant increase in the detection of severe lesions in recent years leading to more burden to resources that are already limited in the middle-income country. Therefore, strategic and comprehensive pediatric and congenital heart surgery program is required.
format Article
author Mat Bah, Mohd Nizam
Sapian, Mohd Hanafi
Jamil, Mohammad Tamim
Abdullah, Nisah
Alias, Emieliyuza Yusnita
Zahari, Norazah
author_facet Mat Bah, Mohd Nizam
Sapian, Mohd Hanafi
Jamil, Mohammad Tamim
Abdullah, Nisah
Alias, Emieliyuza Yusnita
Zahari, Norazah
author_sort Mat Bah, Mohd Nizam
title The birth prevalence, severity, and temporal trends of congenital heart disease in the middle-income country: A population-based study
title_short The birth prevalence, severity, and temporal trends of congenital heart disease in the middle-income country: A population-based study
title_full The birth prevalence, severity, and temporal trends of congenital heart disease in the middle-income country: A population-based study
title_fullStr The birth prevalence, severity, and temporal trends of congenital heart disease in the middle-income country: A population-based study
title_full_unstemmed The birth prevalence, severity, and temporal trends of congenital heart disease in the middle-income country: A population-based study
title_sort birth prevalence, severity, and temporal trends of congenital heart disease in the middle-income country: a population-based study
publisher Wiley
publishDate 2018
url http://eprints.um.edu.my/21320/
https://doi.org/10.1111/chd.12672
_version_ 1643691530252189696
score 13.211869

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