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Associations of clothing size, adiposity and weight change with risk of postmenopausal breast cancer in the UK Women’s Cohort Study (UKWCS)

OBJECTIVES: Breast cancer is associated with overweight and obesity after menopause. However, clothing size as a proxy of adiposity in predicting postmenopausal breast cancer is not widely studied. We aimed to explore the relationships between postmenopausal breast cancer risk with adipose indicator...

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Main Authors: Moy, Foong Ming, Greenwood, Darren Charles, Cade, Janet Elizabeth
Format: Article
Published: BMJ Publishing Group 2018
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/21213/
https://doi.org/10.1136/bmjopen-2018-022599
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spelling my.um.eprints.212132019-05-09T08:39:38Z http://eprints.um.edu.my/21213/ Associations of clothing size, adiposity and weight change with risk of postmenopausal breast cancer in the UK Women’s Cohort Study (UKWCS) Moy, Foong Ming Greenwood, Darren Charles Cade, Janet Elizabeth R Medicine OBJECTIVES: Breast cancer is associated with overweight and obesity after menopause. However, clothing size as a proxy of adiposity in predicting postmenopausal breast cancer is not widely studied. We aimed to explore the relationships between postmenopausal breast cancer risk with adipose indicators (including clothing sizes) and weight change over adulthood. DESIGN: Prospective cohort study. SETTING: England, Wales and Scotland. PARTICIPANTS: 17 781 postmenopausal women from the UK Women's Cohort Study. PRIMARY OUTCOME MEASURE: Incident cases of malignant breast cancers (International Classification of Diseases (ICD) 9 code 174 and ICD 10 code C50). RESULTS: From 282 277 person-years follow-up, there were 946 incident breast cancer cases with an incidence rate of 3.35 per 1000 women. Body mass index (HR: 1.04; 95% CI: 1.02 to 1.07), blouse size (HR: 1.10; 1.03 to 1.18), waist circumference (HR: 1.07; 1.01 to 1.14) and skirt size (HR: 1.14;1.06 to 1.22) had positive associations with postmenopausal breast cancer after adjustment for potential confounders. Increased weight over adulthood (HR: 1.02; 1.01 to 1.03) was also associated with increased risk for postmenopausal breast cancer. CONCLUSIONS: Blouse and skirt sizes can be used as adipose indicators in predicting postmenopausal breast cancer. Maintaining healthy body weight over adulthood is an effective measure in the prevention of postmenopausal breast cancer. BMJ Publishing Group 2018 Article PeerReviewed Moy, Foong Ming and Greenwood, Darren Charles and Cade, Janet Elizabeth (2018) Associations of clothing size, adiposity and weight change with risk of postmenopausal breast cancer in the UK Women’s Cohort Study (UKWCS). BMJ Open, 8 (9). e022599. ISSN 2044-6055 https://doi.org/10.1136/bmjopen-2018-022599 doi:10.1136/bmjopen-2018-022599
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Moy, Foong Ming
Greenwood, Darren Charles
Cade, Janet Elizabeth
Associations of clothing size, adiposity and weight change with risk of postmenopausal breast cancer in the UK Women’s Cohort Study (UKWCS)
description OBJECTIVES: Breast cancer is associated with overweight and obesity after menopause. However, clothing size as a proxy of adiposity in predicting postmenopausal breast cancer is not widely studied. We aimed to explore the relationships between postmenopausal breast cancer risk with adipose indicators (including clothing sizes) and weight change over adulthood. DESIGN: Prospective cohort study. SETTING: England, Wales and Scotland. PARTICIPANTS: 17 781 postmenopausal women from the UK Women's Cohort Study. PRIMARY OUTCOME MEASURE: Incident cases of malignant breast cancers (International Classification of Diseases (ICD) 9 code 174 and ICD 10 code C50). RESULTS: From 282 277 person-years follow-up, there were 946 incident breast cancer cases with an incidence rate of 3.35 per 1000 women. Body mass index (HR: 1.04; 95% CI: 1.02 to 1.07), blouse size (HR: 1.10; 1.03 to 1.18), waist circumference (HR: 1.07; 1.01 to 1.14) and skirt size (HR: 1.14;1.06 to 1.22) had positive associations with postmenopausal breast cancer after adjustment for potential confounders. Increased weight over adulthood (HR: 1.02; 1.01 to 1.03) was also associated with increased risk for postmenopausal breast cancer. CONCLUSIONS: Blouse and skirt sizes can be used as adipose indicators in predicting postmenopausal breast cancer. Maintaining healthy body weight over adulthood is an effective measure in the prevention of postmenopausal breast cancer.
format Article
author Moy, Foong Ming
Greenwood, Darren Charles
Cade, Janet Elizabeth
author_facet Moy, Foong Ming
Greenwood, Darren Charles
Cade, Janet Elizabeth
author_sort Moy, Foong Ming
title Associations of clothing size, adiposity and weight change with risk of postmenopausal breast cancer in the UK Women’s Cohort Study (UKWCS)
title_short Associations of clothing size, adiposity and weight change with risk of postmenopausal breast cancer in the UK Women’s Cohort Study (UKWCS)
title_full Associations of clothing size, adiposity and weight change with risk of postmenopausal breast cancer in the UK Women’s Cohort Study (UKWCS)
title_fullStr Associations of clothing size, adiposity and weight change with risk of postmenopausal breast cancer in the UK Women’s Cohort Study (UKWCS)
title_full_unstemmed Associations of clothing size, adiposity and weight change with risk of postmenopausal breast cancer in the UK Women’s Cohort Study (UKWCS)
title_sort associations of clothing size, adiposity and weight change with risk of postmenopausal breast cancer in the uk women’s cohort study (ukwcs)
publisher BMJ Publishing Group
publishDate 2018
url http://eprints.um.edu.my/21213/
https://doi.org/10.1136/bmjopen-2018-022599
_version_ 1643691499508989952
score 13.211869

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