Staff View: A screen printed carbon electrode modified with carbon nanotubes and gold nanoparticles as a sensitive electrochemical sensor for determination of thiamphenicol residue in milk

A screen printed carbon electrode modified with carbon nanotubes and gold nanoparticles as a sensitive electrochemical sensor for determination of thiamphenicol residue in milk

Antibiotic residues in milk are of great concern for health regulatory agencies, milk consumers, and dairy farmers due to their destructive effects, ranging from allergic reactions, antibiotic resistance and the ability to interfere with the production of fermented products (i.e. cheese and yogurt)....

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Main Authors:	Muhammad, Aliyu, Hajian, Reza, Yusof, Nor Azah, Shams, Nafiseh, Abdullah, Jaafar, Woi, Pei Meng, Garmestani, Hamid
Format:	Article
Published:	Royal Society of Chemistry 2018
Subjects:	Q Science (General) QD Chemistry
Online Access:	http://eprints.um.edu.my/21207/ https://doi.org/10.1039/c7ra07544h
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spelling	my.um.eprints.212072019-05-09T08:04:59Z http://eprints.um.edu.my/21207/ A screen printed carbon electrode modified with carbon nanotubes and gold nanoparticles as a sensitive electrochemical sensor for determination of thiamphenicol residue in milk Muhammad, Aliyu Hajian, Reza Yusof, Nor Azah Shams, Nafiseh Abdullah, Jaafar Woi, Pei Meng Garmestani, Hamid Q Science (General) QD Chemistry Antibiotic residues in milk are of great concern for health regulatory agencies, milk consumers, and dairy farmers due to their destructive effects, ranging from allergic reactions, antibiotic resistance and the ability to interfere with the production of fermented products (i.e. cheese and yogurt). Therefore, a reliable, fast, and simple method needs to be developed to monitor antibiotic residues in milk samples before distribution to consumers. In this study, the first sensitive electrochemical sensor is presented for the determination of thiamphenicol (TAP), a broad-spectrum antibiotic in bovine milk. In the fabrication process, a screen printed electrode (SPE) was modified with gold nanoparticles (AuNPs) and carbon nanotubes (CNTs) using ethylenediamine (en) as a cross linker. Cyclic voltammetry studies showed an adsorptive control process for the electro-oxidation of TAP at-0.1 V on the modified electrode of SPE/CNT/en/AuNPs. Differential pulse voltammetry (DPV) was applied for the quantitative determination of TAP under optimized conditions (0.1 M citrate buffer, pH 6.0, accumulation potential-0.7 V, and accumulation time 150 s). A DPV study for TAP shows a wide linear calibration range of 0.1-30 μM with the detection limit of 0.003 μM. Furthermore, the developed sensor displays high sensitivity, reproducibility, repeatability, and good stability for the detection of TAP. The proposed sensor was successfully applied for the determination of spiked TAP in bovine milk with satisfactory results. Royal Society of Chemistry 2018 Article PeerReviewed Muhammad, Aliyu and Hajian, Reza and Yusof, Nor Azah and Shams, Nafiseh and Abdullah, Jaafar and Woi, Pei Meng and Garmestani, Hamid (2018) A screen printed carbon electrode modified with carbon nanotubes and gold nanoparticles as a sensitive electrochemical sensor for determination of thiamphenicol residue in milk. RSC Advances, 8 (5). pp. 2714-2722. ISSN 2046-2069 https://doi.org/10.1039/c7ra07544h doi:10.1039/c7ra07544h
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	Q Science (General) QD Chemistry
spellingShingle	Q Science (General) QD Chemistry Muhammad, Aliyu Hajian, Reza Yusof, Nor Azah Shams, Nafiseh Abdullah, Jaafar Woi, Pei Meng Garmestani, Hamid A screen printed carbon electrode modified with carbon nanotubes and gold nanoparticles as a sensitive electrochemical sensor for determination of thiamphenicol residue in milk
description	Antibiotic residues in milk are of great concern for health regulatory agencies, milk consumers, and dairy farmers due to their destructive effects, ranging from allergic reactions, antibiotic resistance and the ability to interfere with the production of fermented products (i.e. cheese and yogurt). Therefore, a reliable, fast, and simple method needs to be developed to monitor antibiotic residues in milk samples before distribution to consumers. In this study, the first sensitive electrochemical sensor is presented for the determination of thiamphenicol (TAP), a broad-spectrum antibiotic in bovine milk. In the fabrication process, a screen printed electrode (SPE) was modified with gold nanoparticles (AuNPs) and carbon nanotubes (CNTs) using ethylenediamine (en) as a cross linker. Cyclic voltammetry studies showed an adsorptive control process for the electro-oxidation of TAP at-0.1 V on the modified electrode of SPE/CNT/en/AuNPs. Differential pulse voltammetry (DPV) was applied for the quantitative determination of TAP under optimized conditions (0.1 M citrate buffer, pH 6.0, accumulation potential-0.7 V, and accumulation time 150 s). A DPV study for TAP shows a wide linear calibration range of 0.1-30 μM with the detection limit of 0.003 μM. Furthermore, the developed sensor displays high sensitivity, reproducibility, repeatability, and good stability for the detection of TAP. The proposed sensor was successfully applied for the determination of spiked TAP in bovine milk with satisfactory results.
format	Article
author	Muhammad, Aliyu Hajian, Reza Yusof, Nor Azah Shams, Nafiseh Abdullah, Jaafar Woi, Pei Meng Garmestani, Hamid
author_facet	Muhammad, Aliyu Hajian, Reza Yusof, Nor Azah Shams, Nafiseh Abdullah, Jaafar Woi, Pei Meng Garmestani, Hamid
author_sort	Muhammad, Aliyu
title	A screen printed carbon electrode modified with carbon nanotubes and gold nanoparticles as a sensitive electrochemical sensor for determination of thiamphenicol residue in milk
title_short	A screen printed carbon electrode modified with carbon nanotubes and gold nanoparticles as a sensitive electrochemical sensor for determination of thiamphenicol residue in milk
title_full	A screen printed carbon electrode modified with carbon nanotubes and gold nanoparticles as a sensitive electrochemical sensor for determination of thiamphenicol residue in milk
title_fullStr	A screen printed carbon electrode modified with carbon nanotubes and gold nanoparticles as a sensitive electrochemical sensor for determination of thiamphenicol residue in milk
title_full_unstemmed	A screen printed carbon electrode modified with carbon nanotubes and gold nanoparticles as a sensitive electrochemical sensor for determination of thiamphenicol residue in milk
title_sort	screen printed carbon electrode modified with carbon nanotubes and gold nanoparticles as a sensitive electrochemical sensor for determination of thiamphenicol residue in milk
publisher	Royal Society of Chemistry
publishDate	2018
url	http://eprints.um.edu.my/21207/ https://doi.org/10.1039/c7ra07544h
_version_	1643691497758916608
score	13.211869

A screen printed carbon electrode modified with carbon nanotubes and gold nanoparticles as a sensitive electrochemical sensor for determination of thiamphenicol residue in milk

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