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Anti-infective activities of 11 plants species used in traditional medicine in Malaysia

Treatment of drug resistant protozoa, bacteria, and viruses requires new drugs with alternative chemotypes. Such compounds could be found from Southeast Asian medicinal plants. The present study examines the cytotoxic, antileishmanial, and antiplasmodial effects of 11 ethnopharmacologically importan...

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Main Authors:	Nor Azman, Nadiah Syafiqah, Hossan, Md Shahadat, Nissapatorn, Veeranoot, Uthaipibull, Chairat, Prommana, Parichat, Jin, Khoo Teng, Rahmatullah, Mohammed, Mahboob, Tooba, Samudi, Chandramathi, Jindal, Hassan Mahmood, Hazra, Banasri, Mohd Abd Razak, Mohd Ridzuan, Prajapati, Vijay Kumar, Pandey, Rajan Kumar, Aminudin, Norhaniza, Shaari, Khozirah, Ismail, Nor Hadiani, Butler, Mark S., Zarubaev, Vladimir V., Wiart, Christophe
Format:	Article
Published:	Elsevier 2018
Subjects:	Q Science (General) QH Natural history R Medicine
Online Access:	http://eprints.um.edu.my/21115/ https://doi.org/10.1016/j.exppara.2018.09.020
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spelling	my.um.eprints.211152019-05-03T07:44:30Z http://eprints.um.edu.my/21115/ Anti-infective activities of 11 plants species used in traditional medicine in Malaysia Nor Azman, Nadiah Syafiqah Hossan, Md Shahadat Nissapatorn, Veeranoot Uthaipibull, Chairat Prommana, Parichat Jin, Khoo Teng Rahmatullah, Mohammed Mahboob, Tooba Samudi, Chandramathi Jindal, Hassan Mahmood Hazra, Banasri Mohd Abd Razak, Mohd Ridzuan Prajapati, Vijay Kumar Pandey, Rajan Kumar Aminudin, Norhaniza Shaari, Khozirah Ismail, Nor Hadiani Butler, Mark S. Zarubaev, Vladimir V. Wiart, Christophe Q Science (General) QH Natural history R Medicine Treatment of drug resistant protozoa, bacteria, and viruses requires new drugs with alternative chemotypes. Such compounds could be found from Southeast Asian medicinal plants. The present study examines the cytotoxic, antileishmanial, and antiplasmodial effects of 11 ethnopharmacologically important plant species in Malaysia. Chloroform extracts were tested for their toxicity against MRC-5 cells and Leishmania donovani by MTT, and chloroquine-resistant Plasmodium falciparum K1 strain by Histidine-Rich Protein II ELISA assays. None of the extract tested was cytotoxic to MRC-5 cells. Extracts of Uvaria grandiflora, Chilocarpus costatus, Tabernaemontana peduncularis, and Leuconotis eugenifolius had good activities against L. donovani with IC50 < 50 μg/mL. Extracts of U. grandiflora, C. costatus, T. peduncularis, L. eugenifolius, A. subulatum, and C. aeruginosa had good activities against P. falciparum K1 with IC50 < 10 μg/mL. Pinoresinol isolated from C. costatus was inactive against L. donovani and P. falciparum. C. costatus extract and pinoresinol increased the sensitivity of Staphylococcus epidermidis to cefotaxime. Pinoresinol demonstrated moderate activity against influenza virus (IC50 = 30.4 ± 11 μg/mL) and was active against Coxsackie virus B3 (IC50 = 7.1 ± 3.0 μg/mL). β-Amyrin from L. eugenifolius inhibited L. donovani with IC50 value of 15.4 ± 0.01 μM. Furanodienone from C. aeruginosa inhibited L. donovani and P. falciparum K1 with IC50 value of 39.5 ± 0.2 and 17.0 ± 0.05 μM, respectively. Furanodienone also inhibited the replication of influenza and Coxsackie virus B3 with IC50 value of 4.0 ± 0.5 and 7.2 ± 1.4 μg/mL (Ribavirin: IC50: 15.6 ± 2.0 μg/mL), respectively. Our study provides evidence that medicinal plants in Malaysia have potentials as a source of chemotypes for the development of anti-infective leads. Elsevier 2018 Article PeerReviewed Nor Azman, Nadiah Syafiqah and Hossan, Md Shahadat and Nissapatorn, Veeranoot and Uthaipibull, Chairat and Prommana, Parichat and Jin, Khoo Teng and Rahmatullah, Mohammed and Mahboob, Tooba and Samudi, Chandramathi and Jindal, Hassan Mahmood and Hazra, Banasri and Mohd Abd Razak, Mohd Ridzuan and Prajapati, Vijay Kumar and Pandey, Rajan Kumar and Aminudin, Norhaniza and Shaari, Khozirah and Ismail, Nor Hadiani and Butler, Mark S. and Zarubaev, Vladimir V. and Wiart, Christophe (2018) Anti-infective activities of 11 plants species used in traditional medicine in Malaysia. Experimental Parasitology, 194. pp. 67-78. ISSN 0014-4894 https://doi.org/10.1016/j.exppara.2018.09.020 doi:10.1016/j.exppara.2018.09.020
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	Q Science (General) QH Natural history R Medicine
spellingShingle	Q Science (General) QH Natural history R Medicine Nor Azman, Nadiah Syafiqah Hossan, Md Shahadat Nissapatorn, Veeranoot Uthaipibull, Chairat Prommana, Parichat Jin, Khoo Teng Rahmatullah, Mohammed Mahboob, Tooba Samudi, Chandramathi Jindal, Hassan Mahmood Hazra, Banasri Mohd Abd Razak, Mohd Ridzuan Prajapati, Vijay Kumar Pandey, Rajan Kumar Aminudin, Norhaniza Shaari, Khozirah Ismail, Nor Hadiani Butler, Mark S. Zarubaev, Vladimir V. Wiart, Christophe Anti-infective activities of 11 plants species used in traditional medicine in Malaysia
description	Treatment of drug resistant protozoa, bacteria, and viruses requires new drugs with alternative chemotypes. Such compounds could be found from Southeast Asian medicinal plants. The present study examines the cytotoxic, antileishmanial, and antiplasmodial effects of 11 ethnopharmacologically important plant species in Malaysia. Chloroform extracts were tested for their toxicity against MRC-5 cells and Leishmania donovani by MTT, and chloroquine-resistant Plasmodium falciparum K1 strain by Histidine-Rich Protein II ELISA assays. None of the extract tested was cytotoxic to MRC-5 cells. Extracts of Uvaria grandiflora, Chilocarpus costatus, Tabernaemontana peduncularis, and Leuconotis eugenifolius had good activities against L. donovani with IC50 < 50 μg/mL. Extracts of U. grandiflora, C. costatus, T. peduncularis, L. eugenifolius, A. subulatum, and C. aeruginosa had good activities against P. falciparum K1 with IC50 < 10 μg/mL. Pinoresinol isolated from C. costatus was inactive against L. donovani and P. falciparum. C. costatus extract and pinoresinol increased the sensitivity of Staphylococcus epidermidis to cefotaxime. Pinoresinol demonstrated moderate activity against influenza virus (IC50 = 30.4 ± 11 μg/mL) and was active against Coxsackie virus B3 (IC50 = 7.1 ± 3.0 μg/mL). β-Amyrin from L. eugenifolius inhibited L. donovani with IC50 value of 15.4 ± 0.01 μM. Furanodienone from C. aeruginosa inhibited L. donovani and P. falciparum K1 with IC50 value of 39.5 ± 0.2 and 17.0 ± 0.05 μM, respectively. Furanodienone also inhibited the replication of influenza and Coxsackie virus B3 with IC50 value of 4.0 ± 0.5 and 7.2 ± 1.4 μg/mL (Ribavirin: IC50: 15.6 ± 2.0 μg/mL), respectively. Our study provides evidence that medicinal plants in Malaysia have potentials as a source of chemotypes for the development of anti-infective leads.
format	Article
author	Nor Azman, Nadiah Syafiqah Hossan, Md Shahadat Nissapatorn, Veeranoot Uthaipibull, Chairat Prommana, Parichat Jin, Khoo Teng Rahmatullah, Mohammed Mahboob, Tooba Samudi, Chandramathi Jindal, Hassan Mahmood Hazra, Banasri Mohd Abd Razak, Mohd Ridzuan Prajapati, Vijay Kumar Pandey, Rajan Kumar Aminudin, Norhaniza Shaari, Khozirah Ismail, Nor Hadiani Butler, Mark S. Zarubaev, Vladimir V. Wiart, Christophe
author_facet	Nor Azman, Nadiah Syafiqah Hossan, Md Shahadat Nissapatorn, Veeranoot Uthaipibull, Chairat Prommana, Parichat Jin, Khoo Teng Rahmatullah, Mohammed Mahboob, Tooba Samudi, Chandramathi Jindal, Hassan Mahmood Hazra, Banasri Mohd Abd Razak, Mohd Ridzuan Prajapati, Vijay Kumar Pandey, Rajan Kumar Aminudin, Norhaniza Shaari, Khozirah Ismail, Nor Hadiani Butler, Mark S. Zarubaev, Vladimir V. Wiart, Christophe
author_sort	Nor Azman, Nadiah Syafiqah
title	Anti-infective activities of 11 plants species used in traditional medicine in Malaysia
title_short	Anti-infective activities of 11 plants species used in traditional medicine in Malaysia
title_full	Anti-infective activities of 11 plants species used in traditional medicine in Malaysia
title_fullStr	Anti-infective activities of 11 plants species used in traditional medicine in Malaysia
title_full_unstemmed	Anti-infective activities of 11 plants species used in traditional medicine in Malaysia
title_sort	anti-infective activities of 11 plants species used in traditional medicine in malaysia
publisher	Elsevier
publishDate	2018
url	http://eprints.um.edu.my/21115/ https://doi.org/10.1016/j.exppara.2018.09.020
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score	13.211869

Anti-infective activities of 11 plants species used in traditional medicine in Malaysia

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