Cover Image

Inositol-6 phosphate inhibits the mTOR pathway and induces autophagy-mediated death in HT-29 colon cancer cells

Introduction: Colorectal cancer (CRC) is common, with a worldwide incidence estimated at more than 1 million cases annually. Therefore, the search for agents for CRC treatment is highly warranted. Inositol-6 phosphate (IP6) is enriched in rice bran and possesses many beneficial effects. In the prese...

Full description

Saved in:

Bibliographic Details
Main Authors:	Pandurangan, Ashok Kumar, Ismail, Salmiah, Esa, Norhaizan Mohd, Munusamy, Murugan A.
Format:	Article
Published:	Termedia Publishing House 2018
Subjects:	R Medicine
Online Access:	http://eprints.um.edu.my/21044/ https://doi.org/10.5114/aoms.2018.76935
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Inositol-6 phosphate inhibits the mTOR pathway and induces autophagy-mediated death in HT-29 colon cancer cells
by: Pandurangan, Ashok Kumar, et al.
Published: (2018)

Panduratin A induces protective autophagy in melanoma via the AMPK and mTOR pathway
by: Lai, Siew Li, et al.
Published: (2018)

Pro-apoptotic effect of rice bran inositol hexaphosphate (IP6) on HT-29 colorectal cancer cells
by: Shafie, Nurul Husna, et al.
Published: (2013)

Isolation and characterization of lectin from the Artist’s Conk medicinal mushroom, Ganoderma applanatum (Agaricomycetes) and evaluation of its antiproliferative activity in HT-29 colon cancer cells
by: Kumaran, Sekar, et al.
Published: (2017)

Anticancer potential of Alternanthera sessilis extract on HT-29 human colon cancer cells
by: Mohd Esa, Norhaizan, et al.
Published: (2018)

Mechanism of chemoprevention against colon cancer cells using combined Gelam honey and Ginger extract via mTOR and Wnt/β-catenin pathways
by: Lee, Heng Wee, et al.
Published: (2015)

Investigation On The Effect Of Fig And Date Vinegar On Ht-29 Human Colon Cancer Cells
by: Ahmed Mahmoud El Kadi, Rana
Published: (2015)

Cytotoxic effects of conjugated linoleic acids on human colon cancer cells (HT-29)
by: Achenef, Melaku Beyene, et al.
Published: (2009)

Characterization and chemoresistance of HT29 (Colon cancer) and TW06 (Nasopharyngeal cancer) tumorspheres
by: Goh, Iris Wen Li
Published: (2014)

Preventive inositol hexaphosphate extracted from rice bran inhibits colorectal cancer through involvement of Wnt/β-catenin and COX-2 pathways
by: Shafie, Nurul Husna, et al.
Published: (2013)

Efficiency of newly formulated camptothecin with β-cyclodextrin-EDTA-Fe3O4 nanoparticle-conjugated nanocarriers as an anti-colon cancer (HT29) drug
by: Krishnan, Poorani, et al.
Published: (2017)

Characterisation of Plant Derived Damnacanthal and Nordamnacantbal Induced Cytotoxicity on Human HT29 Colon Adenocarcinoma Cell Line
by: Khor, Tin Oo
Published: (2001)

siRNA blocking of mammalian target of rapamycin (mTOR) attenuates pathology in annonacin-induced tauopathy in mice
by: Salama, Mohamed M., et al.
Published: (2019)

Elucidating the effects of mTOR inhibitors from Malaysian natural products on tuberous sclerosis complex cell line
by: Zulkipli, Ninie Nadia
Published: (2022)

Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells
by: Tahir, Analhuda Abdullah, et al.
Published: (2015)

A study of bacterial cell immobilization in alginate gel beads for the production of Myo-Inositol Phosphates
by: Mohamad Puad, Noor Illi, et al.
Published: (2011)

Effects of albumin–chlorogenic acid nanoparticles on apoptosis and PI3K/Akt/mTOR pathway inhibitory activity in MDA-MB-435s cells
by: Alzahrani, Badr, et al.
Published: (2023)

Evaluation of metabolomics behavior of human colon cancer HT29 celllines treated with ionic liquid graviola fruit pulp extract
by: Daddiouaissa, Djabir, et al.
Published: (2021)

Cytotoxicity effect of ionic liquid-graviola fruit (Annona muricata) extract to human colon cancer (HT29) cell lines
by: Djabir, Daddiouaissa, et al.
Published: (2021)

The cytotoxic activity of marine sponge-derived fungus aspergillus nomius NC06 against HT29 colon cancer cells
by: Artasasta, Muh. Ade, et al.
Published: (2024)

Structure-based virtual screening towards the discovery of usnic acid derivatives as novel mTOR inhibitor to treat breast cancer
by: Wong, Kelvin Khai Voon, et al.
Published: (2022)

Induction of apoptosis via JNK and AKT/mTOR signaling pathways by Alternanthera sessilis (L.) R.Br. ex DC. in colorectal cancer in vitro and in vivo
by: Sivapragasam, Gothai
Published: (2019)

Preliminary investigation of MYO-INOSITOL phosphates produced by ASUIA279PHYTASE on MCF-7 cancer cells
by: Yusoff, Narazah Mohd, et al.
Published: (2011)

Preliminary investigation of myo-inositol phosphates produced by ASUIA279 phytase on MCF-7 cancer cells.
by: Mohd Yusoff , N., et al.
Published: (2011)

Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells.
by: Mohd Yusoff, Noraini, et al.
Published: (2011)

Xanthorrhizol inhibits cell proliferation, cellular cholesterol uptake in HT29 colon cells and adipogenesis in 3T3-L1 adipocytes
by: Oon, Seok Fang, et al.
Published: (2016)

Virus Newcastle (Baka/Strain Af-2240) Ekspresi Gen Hn Ke dalam Sel Kanser Colon Apoptotik Manusia (Ht-29)
by: Khodai, Samira
Published: (2009)

Pentacyclic triterpenoids isolated from diospyros foxworthyi bakh. (ebenaceae) with its cytotoxic activity against ht-29 human colon cancer cell
by: Ghani, Muhammad Solehin Abd, et al.
Published: (2022)

Brewers' rice attenuated aberrant crypt foci developing in colon of azoxymethane-treated rats
by: Tan, Bee Ling, et al.
Published: (2016)

Molecular targets of colorectal cancer: an insight on intracellular cellular signaling pathways
by: Pandurangan, Ashok Kumar, et al.
Published: (2014)

Cucurbitacin L 2-O-β-Glucoside Demonstrates Apoptogenesis in Colon Adenocarcinoma Cells (HT-29): Involvement of Reactive Oxygen and Nitrogen Species Regulation
by: Abdelwahab, Siddig Ibrahim, et al.
Published: (2012)

Cucurbitacin L 2-O-β-Glucoside demonstrates apoptogenesis in colon adenocarcinoma cells (HT-29): involvement of reactive oxygen and nitrogen species regulation
by: Abdelwahab, S.I., et al.
Published: (2012)

Physicochemical characterization of palladium-, platinum-, silver-doped magnesia nanoparticles and in vitro cytotoxicity in A549 (lung) and HT29 (colon) cancer cell lines
by: Khlaif, Mohamed Qasim
Published: (2019)

Different Polarity Extracts of Polygonum minus towards Cytotoxic Activities against Colon Cancer Cell Lines (HT-29, HCT-116, CT-26)
by: Mohd Adzim Khalili, Rohin, et al.
Published: (2020)

Manilkara zapota (L.) P. Royen leaf water extract triggered apoptosis and activated caspase-dependent pathway in HT-29 human colorectal cancer cell line
by: Tan, Bee Ling, et al.
Published: (2019)

Zerumbone targets the CXCR4-RhoA and PI3K-mTOR signaling axis to reduce motility and proliferation of oral cancer cells
by: Zainal, Nur Syafinaz, et al.
Published: (2018)

Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review
by: Pandurangan, Ashok Kumar, et al.
Published: (2014)

Ginger extract (Zingiber officinale) triggers apoptosis and G0/G1 cells arrest in HCT 116 and HT 29 colon cancer cell lines
by: Abdullah, Shailah, et al.
Published: (2010)

Ethyl acetate partition obtained from the methanol extract of Muntingia calabura leaf exerts effective in vitro antiproliferative activity against the HT-29 colon cancer
by: Zainul Amirudin Zakaria, et al.
Published: (2022)

Water extract of brewers rice induces antiproliferation of human colorectal cancer (HT-29) cell lines via the induction of apoptosis
by: Bee, Ling Tan, et al.
Published: (2015)