Staff View: Lactobacillus helveticus (ATCC 27558) upregulates Runx2 and Bmp2 and modulates bone mineral density in ovariectomy-induced bone loss rats

Lactobacillus helveticus (ATCC 27558) upregulates Runx2 and Bmp2 and modulates bone mineral density in ovariectomy-induced bone loss rats

Purpose: Osteoporosis is one of the major health concerns among the elderly population, especially in postmenopausal women. Many menopausal women over 50 years of age lose their bone density and suffer bone fractures. In addition, many mortality and morbidity cases among the elderly are related to h...

Full description

Saved in:

Bibliographic Details
Main Authors:	Parvaneh, Maria, Karimi, Golgis, Jamaluddin, Rosita, Ng, Angela Min Hwei, Ibrahim, Zuriati, Muhammad, Sani Ismaila
Format:	Article
Published:	Dove Medical Press 2018
Subjects:	R Medicine
Online Access:	http://eprints.um.edu.my/21036/ https://doi.org/10.2147/CIA.S169223
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my.um.eprints.21036
record_format	eprints
spelling	my.um.eprints.210362019-04-19T02:59:58Z http://eprints.um.edu.my/21036/ Lactobacillus helveticus (ATCC 27558) upregulates Runx2 and Bmp2 and modulates bone mineral density in ovariectomy-induced bone loss rats Parvaneh, Maria Karimi, Golgis Jamaluddin, Rosita Ng, Angela Min Hwei Ibrahim, Zuriati Muhammad, Sani Ismaila R Medicine Purpose: Osteoporosis is one of the major health concerns among the elderly population, especially in postmenopausal women. Many menopausal women over 50 years of age lose their bone density and suffer bone fractures. In addition, many mortality and morbidity cases among the elderly are related to hip fracture. This study aims to investigate the effect of Lactobacillus helveticus (L. helveticus) on bone health status among ovariectomized (OVX) bone loss-induced rats. Methods: The rats were either OVX or sham OVX (sham), then were randomly assigned into three groups, G1: sham, G2: OVX and G3: OVX+L. helveticus (1 mL of 10 8 –10 9 colony forming units). The supplementation was force-fed to the rats once a day for 16 weeks while control groups were force-fed with demineralized water. Results: L. helveticus upregulated the expression of Runx2 and Bmp2, increased serum osteocalcin, bone volume/total volume and trabecular thickness, and decreased serum C-terminal telopeptide and total porosity percentage. It also altered bone microstructure, as a result increasing bone mineral density and bone strength. Conclusion: Our results indicate that L. helveticus attenuates bone remodeling and consequently improves bone health in OVX rats by increasing bone formation along with bone resorption reduction. This study suggests a potential therapeutic effect of L. helveticus (ATCC 27558) on postmenopausal osteoporosis Dove Medical Press 2018 Article PeerReviewed Parvaneh, Maria and Karimi, Golgis and Jamaluddin, Rosita and Ng, Angela Min Hwei and Ibrahim, Zuriati and Muhammad, Sani Ismaila (2018) Lactobacillus helveticus (ATCC 27558) upregulates Runx2 and Bmp2 and modulates bone mineral density in ovariectomy-induced bone loss rats. Clinical Interventions in Aging, 13. pp. 1555-1564. ISSN 1178-1998 https://doi.org/10.2147/CIA.S169223 doi:10.2147/CIA.S169223
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine
spellingShingle	R Medicine Parvaneh, Maria Karimi, Golgis Jamaluddin, Rosita Ng, Angela Min Hwei Ibrahim, Zuriati Muhammad, Sani Ismaila Lactobacillus helveticus (ATCC 27558) upregulates Runx2 and Bmp2 and modulates bone mineral density in ovariectomy-induced bone loss rats
description	Purpose: Osteoporosis is one of the major health concerns among the elderly population, especially in postmenopausal women. Many menopausal women over 50 years of age lose their bone density and suffer bone fractures. In addition, many mortality and morbidity cases among the elderly are related to hip fracture. This study aims to investigate the effect of Lactobacillus helveticus (L. helveticus) on bone health status among ovariectomized (OVX) bone loss-induced rats. Methods: The rats were either OVX or sham OVX (sham), then were randomly assigned into three groups, G1: sham, G2: OVX and G3: OVX+L. helveticus (1 mL of 10 8 –10 9 colony forming units). The supplementation was force-fed to the rats once a day for 16 weeks while control groups were force-fed with demineralized water. Results: L. helveticus upregulated the expression of Runx2 and Bmp2, increased serum osteocalcin, bone volume/total volume and trabecular thickness, and decreased serum C-terminal telopeptide and total porosity percentage. It also altered bone microstructure, as a result increasing bone mineral density and bone strength. Conclusion: Our results indicate that L. helveticus attenuates bone remodeling and consequently improves bone health in OVX rats by increasing bone formation along with bone resorption reduction. This study suggests a potential therapeutic effect of L. helveticus (ATCC 27558) on postmenopausal osteoporosis
format	Article
author	Parvaneh, Maria Karimi, Golgis Jamaluddin, Rosita Ng, Angela Min Hwei Ibrahim, Zuriati Muhammad, Sani Ismaila
author_facet	Parvaneh, Maria Karimi, Golgis Jamaluddin, Rosita Ng, Angela Min Hwei Ibrahim, Zuriati Muhammad, Sani Ismaila
author_sort	Parvaneh, Maria
title	Lactobacillus helveticus (ATCC 27558) upregulates Runx2 and Bmp2 and modulates bone mineral density in ovariectomy-induced bone loss rats
title_short	Lactobacillus helveticus (ATCC 27558) upregulates Runx2 and Bmp2 and modulates bone mineral density in ovariectomy-induced bone loss rats
title_full	Lactobacillus helveticus (ATCC 27558) upregulates Runx2 and Bmp2 and modulates bone mineral density in ovariectomy-induced bone loss rats
title_fullStr	Lactobacillus helveticus (ATCC 27558) upregulates Runx2 and Bmp2 and modulates bone mineral density in ovariectomy-induced bone loss rats
title_full_unstemmed	Lactobacillus helveticus (ATCC 27558) upregulates Runx2 and Bmp2 and modulates bone mineral density in ovariectomy-induced bone loss rats
title_sort	lactobacillus helveticus (atcc 27558) upregulates runx2 and bmp2 and modulates bone mineral density in ovariectomy-induced bone loss rats
publisher	Dove Medical Press
publishDate	2018
url	http://eprints.um.edu.my/21036/ https://doi.org/10.2147/CIA.S169223
_version_	1643691447957848064
score	13.211869

Lactobacillus helveticus (ATCC 27558) upregulates Runx2 and Bmp2 and modulates bone mineral density in ovariectomy-induced bone loss rats

Similar Items