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Self-Assembly, Thermotropic, and Lyotropic Phase Behavior of Guerbet Branched-Chain Maltosides

Five synthetic β-d-maltosides derived from Guerbet branched alcohols, whose total hydrocarbon chain length ranged from C8 to C24, were synthesized to a high anomeric purity, and their thermal properties, liquid-crystalline phases, and structures were characterized using differential scanning calorim...

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Main Authors: Saari, Nur Asmak Nabila, Mislan, Azwa Amanina, Hashim, Rauzah, Zahid, Noor Idayu Mat
Format: Article
Published: American Chemical Society 2018
Subjects:
Q Science (General)
QD Chemistry
Online Access:http://eprints.um.edu.my/20848/
https://doi.org/10.1021/acs.langmuir.8b01899
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spelling my.um.eprints.208482019-04-09T04:04:33Z http://eprints.um.edu.my/20848/ Self-Assembly, Thermotropic, and Lyotropic Phase Behavior of Guerbet Branched-Chain Maltosides Saari, Nur Asmak Nabila Mislan, Azwa Amanina Hashim, Rauzah Zahid, Noor Idayu Mat Q Science (General) QD Chemistry Five synthetic β-d-maltosides derived from Guerbet branched alcohols, whose total hydrocarbon chain length ranged from C8 to C24, were synthesized to a high anomeric purity, and their thermal properties, liquid-crystalline phases, and structures were characterized using differential scanning calorimetry, optical polarizing microscopy, and small-angle X-ray scattering. Thermal investigations of all anhydrous Guerbet maltosides showed that they do not form solid crystals but undergo a glass transition upon temperature change in the range of 35-53 °C. The glassy crystalline structure turns into the liquid-crystalline structure upon heating or addition of water. In thermotropic studies, the lamellar phase formation is prominent in shorter-chain-length analogues, whereas the longer-chain compounds exhibit a more frustrated form of self-assembly in the formation of a metastable state, polymorphism, and inverse bicontinuous cubic structure (Ia3d). The excess water conditions show that the phase formation is dominated by the lamellar phase for the longer-chain compounds. Normal micellar solution was observed in the shortest-chain-length maltosides because of the enlargement of hydrated maltose headgroups. The self-assembly of both dry and fully hydrated Guerbet maltosides, which exhibited glass-forming abilities and showed surface activity and also the ability to act as membrane-stabilizing compounds, makes them ideal candidates for practical use in industry as well as biomedical research. American Chemical Society 2018 Article PeerReviewed Saari, Nur Asmak Nabila and Mislan, Azwa Amanina and Hashim, Rauzah and Zahid, Noor Idayu Mat (2018) Self-Assembly, Thermotropic, and Lyotropic Phase Behavior of Guerbet Branched-Chain Maltosides. Langmuir, 34 (30). pp. 8962-8974. ISSN 0743-7463 https://doi.org/10.1021/acs.langmuir.8b01899 doi:10.1021/acs.langmuir.8b01899
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic Q Science (General)
QD Chemistry
spellingShingle Q Science (General)
QD Chemistry
Saari, Nur Asmak Nabila
Mislan, Azwa Amanina
Hashim, Rauzah
Zahid, Noor Idayu Mat
Self-Assembly, Thermotropic, and Lyotropic Phase Behavior of Guerbet Branched-Chain Maltosides
description Five synthetic β-d-maltosides derived from Guerbet branched alcohols, whose total hydrocarbon chain length ranged from C8 to C24, were synthesized to a high anomeric purity, and their thermal properties, liquid-crystalline phases, and structures were characterized using differential scanning calorimetry, optical polarizing microscopy, and small-angle X-ray scattering. Thermal investigations of all anhydrous Guerbet maltosides showed that they do not form solid crystals but undergo a glass transition upon temperature change in the range of 35-53 °C. The glassy crystalline structure turns into the liquid-crystalline structure upon heating or addition of water. In thermotropic studies, the lamellar phase formation is prominent in shorter-chain-length analogues, whereas the longer-chain compounds exhibit a more frustrated form of self-assembly in the formation of a metastable state, polymorphism, and inverse bicontinuous cubic structure (Ia3d). The excess water conditions show that the phase formation is dominated by the lamellar phase for the longer-chain compounds. Normal micellar solution was observed in the shortest-chain-length maltosides because of the enlargement of hydrated maltose headgroups. The self-assembly of both dry and fully hydrated Guerbet maltosides, which exhibited glass-forming abilities and showed surface activity and also the ability to act as membrane-stabilizing compounds, makes them ideal candidates for practical use in industry as well as biomedical research.
format Article
author Saari, Nur Asmak Nabila
Mislan, Azwa Amanina
Hashim, Rauzah
Zahid, Noor Idayu Mat
author_facet Saari, Nur Asmak Nabila
Mislan, Azwa Amanina
Hashim, Rauzah
Zahid, Noor Idayu Mat
author_sort Saari, Nur Asmak Nabila
title Self-Assembly, Thermotropic, and Lyotropic Phase Behavior of Guerbet Branched-Chain Maltosides
title_short Self-Assembly, Thermotropic, and Lyotropic Phase Behavior of Guerbet Branched-Chain Maltosides
title_full Self-Assembly, Thermotropic, and Lyotropic Phase Behavior of Guerbet Branched-Chain Maltosides
title_fullStr Self-Assembly, Thermotropic, and Lyotropic Phase Behavior of Guerbet Branched-Chain Maltosides
title_full_unstemmed Self-Assembly, Thermotropic, and Lyotropic Phase Behavior of Guerbet Branched-Chain Maltosides
title_sort self-assembly, thermotropic, and lyotropic phase behavior of guerbet branched-chain maltosides
publisher American Chemical Society
publishDate 2018
url http://eprints.um.edu.my/20848/
https://doi.org/10.1021/acs.langmuir.8b01899
_version_ 1643691398227034112
score 13.211869

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