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Antioxidative Potential of a Streptomyces sp. MUM292 Isolated from Mangrove Soil

Mangrove derived microorganisms constitute a rich bioresource for bioprospecting of bioactive natural products. This study explored the antioxidant potentials of Streptomyces bacteria derived from mangrove soil. Based on 16S rRNA phylogenetic analysis, strain MUM292 was identified as the genus Strep...

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Main Authors:	Tan, Loh Teng Hern, Chan, Kok Gan, Chan, Chim Kei, Khan, Tahir Mehmood, Lee, Learn Han, Goh, Bey Hing
Format:	Article
Published:	Hindawi Publishing Corporation 2018
Subjects:	Q Science (General) QH Natural history R Medicine
Online Access:	http://eprints.um.edu.my/20533/ https://doi.org/10.1155/2018/4823126
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id	my.um.eprints.20533
record_format	eprints
spelling	my.um.eprints.205332019-02-28T05:01:39Z http://eprints.um.edu.my/20533/ Antioxidative Potential of a Streptomyces sp. MUM292 Isolated from Mangrove Soil Tan, Loh Teng Hern Chan, Kok Gan Chan, Chim Kei Khan, Tahir Mehmood Lee, Learn Han Goh, Bey Hing Q Science (General) QH Natural history R Medicine Mangrove derived microorganisms constitute a rich bioresource for bioprospecting of bioactive natural products. This study explored the antioxidant potentials of Streptomyces bacteria derived from mangrove soil. Based on 16S rRNA phylogenetic analysis, strain MUM292 was identified as the genus Streptomyces. Strain MUM292 showed the highest 16S rRNA gene sequence similarity of 99.54% with S. griseoruber NBRC12873T. Furthermore, strain MUM292 was also characterized and showed phenotypic characteristics consistent with Streptomyces bacteria. Fermentation and extraction were performed to obtain the MUM292 extract containing the secondary metabolites of strain MUM292. The extract displayed promising antioxidant activities, including DPPH, ABTS, and superoxide radical scavenging and also metal-chelating activities. The process of lipid peroxidation in lipid-rich product was also retarded by MUM292 extract and resulted in reduced MDA production. The potential bioactive constituents of MUM292 extract were investigated using GC-MS and preliminary detection showed the presence of pyrazine, pyrrole, cyclic dipeptides, and phenolic compound in MUM292 extract. This work demonstrates that Streptomyces MUM292 can be a potential antioxidant resource for food and pharmaceutical industries. Hindawi Publishing Corporation 2018 Article PeerReviewed Tan, Loh Teng Hern and Chan, Kok Gan and Chan, Chim Kei and Khan, Tahir Mehmood and Lee, Learn Han and Goh, Bey Hing (2018) Antioxidative Potential of a Streptomyces sp. MUM292 Isolated from Mangrove Soil. BioMed Research International, 2018. pp. 1-13. ISSN 2314-6133 https://doi.org/10.1155/2018/4823126 doi:10.1155/2018/4823126
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	Q Science (General) QH Natural history R Medicine
spellingShingle	Q Science (General) QH Natural history R Medicine Tan, Loh Teng Hern Chan, Kok Gan Chan, Chim Kei Khan, Tahir Mehmood Lee, Learn Han Goh, Bey Hing Antioxidative Potential of a Streptomyces sp. MUM292 Isolated from Mangrove Soil
description	Mangrove derived microorganisms constitute a rich bioresource for bioprospecting of bioactive natural products. This study explored the antioxidant potentials of Streptomyces bacteria derived from mangrove soil. Based on 16S rRNA phylogenetic analysis, strain MUM292 was identified as the genus Streptomyces. Strain MUM292 showed the highest 16S rRNA gene sequence similarity of 99.54% with S. griseoruber NBRC12873T. Furthermore, strain MUM292 was also characterized and showed phenotypic characteristics consistent with Streptomyces bacteria. Fermentation and extraction were performed to obtain the MUM292 extract containing the secondary metabolites of strain MUM292. The extract displayed promising antioxidant activities, including DPPH, ABTS, and superoxide radical scavenging and also metal-chelating activities. The process of lipid peroxidation in lipid-rich product was also retarded by MUM292 extract and resulted in reduced MDA production. The potential bioactive constituents of MUM292 extract were investigated using GC-MS and preliminary detection showed the presence of pyrazine, pyrrole, cyclic dipeptides, and phenolic compound in MUM292 extract. This work demonstrates that Streptomyces MUM292 can be a potential antioxidant resource for food and pharmaceutical industries.
format	Article
author	Tan, Loh Teng Hern Chan, Kok Gan Chan, Chim Kei Khan, Tahir Mehmood Lee, Learn Han Goh, Bey Hing
author_facet	Tan, Loh Teng Hern Chan, Kok Gan Chan, Chim Kei Khan, Tahir Mehmood Lee, Learn Han Goh, Bey Hing
author_sort	Tan, Loh Teng Hern
title	Antioxidative Potential of a Streptomyces sp. MUM292 Isolated from Mangrove Soil
title_short	Antioxidative Potential of a Streptomyces sp. MUM292 Isolated from Mangrove Soil
title_full	Antioxidative Potential of a Streptomyces sp. MUM292 Isolated from Mangrove Soil
title_fullStr	Antioxidative Potential of a Streptomyces sp. MUM292 Isolated from Mangrove Soil
title_full_unstemmed	Antioxidative Potential of a Streptomyces sp. MUM292 Isolated from Mangrove Soil
title_sort	antioxidative potential of a streptomyces sp. mum292 isolated from mangrove soil
publisher	Hindawi Publishing Corporation
publishDate	2018
url	http://eprints.um.edu.my/20533/ https://doi.org/10.1155/2018/4823126
_version_	1643691307848171520
score	13.211869

Antioxidative Potential of a Streptomyces sp. MUM292 Isolated from Mangrove Soil

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