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3D–printed biphasic calcium phosphate scaffolds coated with an oxygen generating system for enhancing engineered tissue survival

Tissue engineering scaffolds with oxygen generating elements have shown to be able to increase the level of oxygen and cell survivability in specific conditions. In this study, biphasic calcium phosphate (BCP) scaffolds with the composition of 60% hydroxyapatite (HA) and 40% beta-tricalcium phosphat...

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Main Authors:	Touri, Maria, Moztarzadeh, Fathollah, Abu Osman, Noor Azuan, Dehghan, Mohammad Mehdi, Mozafari, Masoud
Format:	Article
Published:	Elsevier 2018
Subjects:	R Medicine
Online Access:	http://eprints.um.edu.my/20456/ https://doi.org/10.1016/j.msec.2017.11.037
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spelling	my.um.eprints.204562019-02-22T08:58:38Z http://eprints.um.edu.my/20456/ 3D–printed biphasic calcium phosphate scaffolds coated with an oxygen generating system for enhancing engineered tissue survival Touri, Maria Moztarzadeh, Fathollah Abu Osman, Noor Azuan Dehghan, Mohammad Mehdi Mozafari, Masoud R Medicine Tissue engineering scaffolds with oxygen generating elements have shown to be able to increase the level of oxygen and cell survivability in specific conditions. In this study, biphasic calcium phosphate (BCP) scaffolds with the composition of 60% hydroxyapatite (HA) and 40% beta-tricalcium phosphate (β-TCP), which have shown a great potential for bone tissue engineering applications, were fabricated by a direct-write assembly (robocasting) technique. Then, the three-dimensional (3D)-printed scaffolds were coated with different ratios of an oxygen releasing agent, calcium peroxide (CPO), which encapsulated within a polycaprolactone (PCL) matrix through dip-coating, and used for in situ production of oxygen in the implanted sites. The structure, composition and morphology of the prepared scaffolds were characterized by different techniques. The oxygen release kinetics and biological investigations of the scaffolds were also studied in vitro. The results showed that oxygen release behaviour was sustained and dependant on the concentration of CPO encapsulated in the PCL coating matrix. It was also demonstrated that the coated scaffolds, having 3% CPO in the coating system, could provide a great potential for promoting bone ingrowth with improving osteoblast cells viability and proliferation under hypoxic conditions. The findings indicated that the prepared scaffolds could play a significant role in engineering of large bone tissue implants with limitations in oxygen diffusion. Elsevier 2018 Article PeerReviewed Touri, Maria and Moztarzadeh, Fathollah and Abu Osman, Noor Azuan and Dehghan, Mohammad Mehdi and Mozafari, Masoud (2018) 3D–printed biphasic calcium phosphate scaffolds coated with an oxygen generating system for enhancing engineered tissue survival. Materials Science and Engineering: C, 84. pp. 236-242. ISSN 0928-4931 https://doi.org/10.1016/j.msec.2017.11.037 doi:10.1016/j.msec.2017.11.037
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine
spellingShingle	R Medicine Touri, Maria Moztarzadeh, Fathollah Abu Osman, Noor Azuan Dehghan, Mohammad Mehdi Mozafari, Masoud 3D–printed biphasic calcium phosphate scaffolds coated with an oxygen generating system for enhancing engineered tissue survival
description	Tissue engineering scaffolds with oxygen generating elements have shown to be able to increase the level of oxygen and cell survivability in specific conditions. In this study, biphasic calcium phosphate (BCP) scaffolds with the composition of 60% hydroxyapatite (HA) and 40% beta-tricalcium phosphate (β-TCP), which have shown a great potential for bone tissue engineering applications, were fabricated by a direct-write assembly (robocasting) technique. Then, the three-dimensional (3D)-printed scaffolds were coated with different ratios of an oxygen releasing agent, calcium peroxide (CPO), which encapsulated within a polycaprolactone (PCL) matrix through dip-coating, and used for in situ production of oxygen in the implanted sites. The structure, composition and morphology of the prepared scaffolds were characterized by different techniques. The oxygen release kinetics and biological investigations of the scaffolds were also studied in vitro. The results showed that oxygen release behaviour was sustained and dependant on the concentration of CPO encapsulated in the PCL coating matrix. It was also demonstrated that the coated scaffolds, having 3% CPO in the coating system, could provide a great potential for promoting bone ingrowth with improving osteoblast cells viability and proliferation under hypoxic conditions. The findings indicated that the prepared scaffolds could play a significant role in engineering of large bone tissue implants with limitations in oxygen diffusion.
format	Article
author	Touri, Maria Moztarzadeh, Fathollah Abu Osman, Noor Azuan Dehghan, Mohammad Mehdi Mozafari, Masoud
author_facet	Touri, Maria Moztarzadeh, Fathollah Abu Osman, Noor Azuan Dehghan, Mohammad Mehdi Mozafari, Masoud
author_sort	Touri, Maria
title	3D–printed biphasic calcium phosphate scaffolds coated with an oxygen generating system for enhancing engineered tissue survival
title_short	3D–printed biphasic calcium phosphate scaffolds coated with an oxygen generating system for enhancing engineered tissue survival
title_full	3D–printed biphasic calcium phosphate scaffolds coated with an oxygen generating system for enhancing engineered tissue survival
title_fullStr	3D–printed biphasic calcium phosphate scaffolds coated with an oxygen generating system for enhancing engineered tissue survival
title_full_unstemmed	3D–printed biphasic calcium phosphate scaffolds coated with an oxygen generating system for enhancing engineered tissue survival
title_sort	3d–printed biphasic calcium phosphate scaffolds coated with an oxygen generating system for enhancing engineered tissue survival
publisher	Elsevier
publishDate	2018
url	http://eprints.um.edu.my/20456/ https://doi.org/10.1016/j.msec.2017.11.037
_version_	1643691284537278464
score	13.211869

3D–printed biphasic calcium phosphate scaffolds coated with an oxygen generating system for enhancing engineered tissue survival

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